Correlation between reduced susceptibility to disinfectants and multidrug resistance among clinical isolates of Acinetobacter species

Abstract

Since several Acinetobacter clinical isolates have developed augmented resistance to multiple antimicrobials and disinfectants, it is worth checking the susceptibility to disinfectants if multidrug-resistant Acinetobacter spp. are recurrently isolated clinically.

Roles of Pseudomonas aeruginosa Autoinducers and their Degradation Products, Tetramic acids, in Bacterial Survival and Behavior in Ecological Niches

“…Recent reports have showed that several Acinetobacter clinical isolates have developed augmented resistance to multiple antimicrobials and disinfectants (16). In the present study, a synergistic effect of tetramic acid and disinfectants such as benzalkonium chloride and chlorhexidine gluconate was observed.…”

Relationship between ultrasound bone parameters, lung function, and body mass index in healthy student population

“…As the sensitive group did not differ in MBCs of either disinfectant from the XRD group, there was no evidence that multidrugresistant (MDR) A. baumannii strains were also more resistant to the tested disinfectants. Literature about antibiotic/disinfectant cross-resistance is inconclusive; some studies showed no apparent connection between resistance to antibiotics and resistance to disinfectants (17,18,31), while some found a significant correlation (14,22), some found correlations with certain types of antibiotic but not with others (16), and some concluded that crossresistance was possible (32). We opted for grouping the A. baumannii isolates into sensitive and resistant and for comparing their mean values rather than comparing the MICs of specific antibiotics with the MICs of specific disinfectants, as we believe that such generalisation best represents real-life conditions, since the A. baumannii isolates described here were either multidrug-resistant or sensitive.…”

“…Babaei et al (14) suggest that the reduced susceptibility of A. baumannii to disinfectants correlates with its multidrug resistance, as they found genes encoding resistance to common disinfectants such as quaternary ammonium compounds or chlorhexidine in A. baumannii hospital isolates. Kawamura-Sato et al (15) also found that hospital Acinetobacter spp.…”

Frequency of biocide-resistant genes and susceptibility to chlorhexidine in high-level mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MuH MRSA)

“…Minimum bactericidal concentration (MBC) assays were executed to assess the bactericidal activity of chlorhexidine against MuH MRSA isolates by a quantitative suspension test as described by Kawamura-Sato et al (2010) with a slight modification. Microbial suspension (0.1 ml, ～10 8 cfu/ml) was mixed with 0.9 ml of different concentrations of chlorhexidine solution (prepared by serial 2-fold dilution method using sterile water, range: 0.125-1024 µg/ml) and exposed for 5 min at 20 ± 2 ℃.…”