Correlation between Selected XRCC2, XRCC3 and RAD51 Gene Polymorphisms and Primary Breast Cancer in Women in Pakistan

Qureshi, Zeshan; Mahjabeen, Ishrat; Baig, Ruqia Mehmood; Kayani, Mahmood Akhtar

doi:10.7314/apjcp.2014.15.23.10225

Cited by 29 publications

(21 citation statements)

References 25 publications

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“…XRCC3 is located in the 14q32.3 chromosome region and plays a key role during HR that is essential for DSB repair and maintaining chromosomal stability . To date, many reports have shown that polymorphisms in the XRCC3 gene are associated with an increased risk for various solid tumors, including breast, bladder and lung cancers . However, the expression profile and clinical significance of XRCC3 protein in cancer remain unknown.…”

Section: Discussionsupporting

confidence: 89%

“…(17,22) To date, many reports have shown that polymorphisms in the XRCC3 gene are associated with an increased risk for various solid tumors, including breast, bladder and lung cancers. (23)(24)(25) However, the expression profile and clinical significance of XRCC3 protein in cancer remain unknown. To investigate the potential role of XRCC3 in ESCC, we first examined the expression level of XRCC3 protein by IHC in 20 normal esophageal mucosa tissues and 60 ESCC cases with complete follow-up information.…”

Section: Resultsmentioning

confidence: 99%

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XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma

et al. 2015

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Radiotherapy is widely applied for treatment of esophageal squamous cell carcinoma (ESCC). The Rad51‐related protein XRCC3 plays roles in the recombinational repair of DNA double‐strand breaks to maintain chromosome stability and repair DNA damage. The present study aimed to investigate the effect of XRCC3 on the radiotherapy response of ESCC and the underlying mechanisms of the roles of XRCC3 in ESCC radiosensitivity. XRCC3 expression in ESCC cells and tissues was higher than that in normal esophageal epithelial cells and corresponding adjacent noncancerous esophageal tissue. High XRCC3 expression was positively correlated with resistance to chemoradiotherapy in ESCC and an independent predictor for short disease‐specific survival of ESCC patients. Furthermore, the therapeutic efficacy of radiotherapy in vitro and in vivo was substantially increased by knockdown of XRCC3 in ESCC cells. Ectopic overexpression of XRCC3 in both XRCC3‐silenced ESCC cells dramatically enhanced ESCC cells' resistance to radiotherapy. Moreover, radiation resistance conferred by XRCC3 was attributed to enhancement of homologous recombination, maintenance of telomere stability, and a reduction of ESCC cell death by radiation‐induced apoptosis and mitotic catastrophe. Our data suggest that XRCC3 protects ESCC cells from ionizing radiation‐induced death by promoting DNA damage repair and/or enhancing telomere stability. XRCC3 may be a novel radiosensitivity predictor and promising therapeutic target for ESCC.

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Section: Discussionsupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma

et al. 2015

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“…However, there was no relationship of rs25489, rs25487 and rs13181 with PTC. The mutations in XRCC genes may cause decrease or loss of DNA repair capacity and confer the variation in development of many malignant tumors, and previously, some studies have reported that XRCC1 and XRCC3 gene polymorphisms may modify the risk for some types of cancer, such as gastric cancer [13], glioma [14], breast cancer [15] and colorectal cancer [16]. But to date, less study focused on the association between XRCC gene polymorphisms and PTC risk, especially for Chinese population, and these published literatures could not concluded a consistent result.…”

Section: Discussionmentioning

confidence: 99%

Interaction Between XRCC1 Gene Polymorphisms and Obesity on Susceptibility to Papillary Thyroid Cancer in Chinese Han Population

Zhu¹,

Pan²,

Li³

2018

Cell Physiol Biochem

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Background/Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within XRCC gene and additional gene- environment interaction with papillary thyroid cancer (PTC) risk. Methods: Testing for Hardy-Weinberg equilibrium in controls was conducted using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 5 SNPs within XRCC gene and obesity. Results: Logistic regression analysis showed that the C allele of rs861539 and T allele of rs1799782 were associated with increased PTC risk Adjusted ORs (95%CI) were 1.65 (1.23-2.12) and 1.61 (1.20-2.04). However There was no relation of rs25489 Rs25487 and rs13181 with PTC. The cross-validation consistency and the testing accuracy for each of the models were determined by GMDR analysis. One two-locus model (rs1799782 and obesity) had a testing accuracy of 62.11% Which was significant at the p < 0.01 level. The D’ value between rs1799782 and rs13181 within ERCC1 gene was more than 0.75 (0.825). So haplotype analysis was just conducted for rs1799782 and rs13181 using the SHEsis online haplotype analysis software. In all samples The haplotype C- A was observed most frequently in two groups With 49.46% and 55.79% in the PTC patients and controls Respectively. The results also indicated that haplotype T- C was significantly associated with increased PTC risk. Conclusion: The C allele of rs861539 and T allele of rs1799782 Interaction between rs1799782 and obesity and haplotype T- C were all associated with increased PTC risk.

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“…Several recent studies have investigated the association between XRCC3 Thr241Met polymorphism and different types of cancers, but the results are contradictory. Some studies have found that XRCC3 Thr241Met polymorphism is associated with a high risk of cancer, such as glioma, hepatocellular carcinoma, colorectal cancer, breast cancer, head and neck cancer and gastric cancer (Duan et al, 2013;Luo et al, 2013;Kayani et al, 2014;Nissar et al, 2014;Qureshi et al, 2014). Duan and colleagues investigated the role of XRCC3 Thr241Met polymorphism in hepatocellular carcinoma, and reported that the Met/Met and Thr/Met+Met/Met genotypes were significantly associated with hepatocellular carcinoma in a Chinese population (Duan et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

Guo¹,

Hc²,

Shi³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Osteosarcoma is one of the most common bone malignancies in adolescents, and hereditary factors may influence its susceptibility. We assessed the association between XRCC3 Thr241Met polymorphism and susceptibility to osteosarcoma in a Chinese population. Between May 2012 and May 2014, a total of 136 osteosarcoma patients and 136 healthy control subjects were included in our study. The XRCC3 Thr241Met polymorphism was analyzed using a polymerase chain reaction restriction fragment length polymorphism assay. By multiple logistic regression analysis, individuals carrying the Met/Met genotype of XRCC3 Thr241Met were at significantly increased risk of osteosarcoma when compared with the Thr/Thr (OR = 2.50, 95%CI = 1.13-5.66). The Thr/Met+Met/Met genotype of XRCC3 Thr241Met was furthermore found to be correlated with an elevated increased risk of osteosarcoma when compared with the Thr/Thr genotype (OR = 1.71, 95%CI = 1.03-2.87), and Met/Met genotype of XRCC3 Thr241Met was associated with an increased risk of osteosarcoma compared to the Thr/ Thr (OR = 3.50, 95%CI = 1. 51-8.79). In conclusion, our study firstly reports 16485 XRCC3 Thr241Met polymorphism and osteosarcoma risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16484-16490 (2015) that XRCC3 Thr241Met gene polymorphism is associated with an elavated risk of osteosarcoma.

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Correlation between Selected XRCC2, XRCC3 and RAD51 Gene Polymorphisms and Primary Breast Cancer in Women in Pakistan

Cited by 29 publications

References 25 publications

XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma

XRCC3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma

Interaction Between XRCC1 Gene Polymorphisms and Obesity on Susceptibility to Papillary Thyroid Cancer in Chinese Han Population

Association between XRCC3 Thr241Met polymorphism and risk of osteosarcoma in a Chinese population

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