Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

Peroni, Diego; Piacentini, Giorgio; Cametti, E; Chinellato, Iolanda; Boner, Attilio

doi:10.1111/j.1365-2133.2010.10147.x

Cited by 222 publications

(189 citation statements)

References 36 publications

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“…UVB also stimulates cutaneous synthesis of previtamin D from 7-dehydrocholesterol. Some studies found that AD is associated with low vitamin D levels [145] and that oral vitamin D supplementation improves AD severity [146,147]. Thus, the beneficial effects of UVB may be related to increased vitamin D levels.…”

Section: 42mentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: 42mentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

View full text Add to dashboard Cite

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“…11,18,19 Lower 25OHD levels also appear to correlate with AD severity, which suggests a potential role of VD in the pathogenesis of AD. 5 A prospective birth cohort study supported this association by showing that infants born with cord blood 25OHD levels of ,50 nmol/L had a higher risk of AD at 12 months of age. 20 VD has widespread effects on the immune system and skin integrity.…”

Section: Discussionmentioning

confidence: 62%

“…However, other serious but less recognized AD complications may occur, including abnormalities in bone metabolism. 4,5 AD severity appears to be inversely correlated with serum 25-hydroxyvitamin D (25OHD) levels. 5 The most severe form of vitamin D (VD) deficiency leads to rickets, a disorder of bone metabolism that causes failure of mineralization of the growth plate and osteoid matrix.…”

mentioning

confidence: 99%

Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

et al. 2014

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Atopic dermatitis (AD) affects 10% to 20% of children worldwide. Its severity may be inversely correlated with 25-hydroxyvitamin D (25OHD) levels. Although low levels of vitamin D (VD) can cause rickets in infants, VD deficiency rickets is an unusual presentation in teenagers. We report the case of a 14-year-old girl with severe AD and fish allergy since early childhood. She lived at high latitude (with less sun exposure) and, because of her atopic disorders, avoided sunlight and fish. Laboratory studies showed elevated alkaline phosphatase and parathyroid hormone levels and low serum calcium; her serum 25OHD level was ,12 nmol/L. A radiograph of the wrist showed a radiolucent band in the distal metaphysis of the radius with marginal sclerosis. She was diagnosed as having hypocalcemic rickets due to VD deficiency. Treatment with VD increased her 25OHD level to 44 nmol/L, with normalization of alkaline phosphatase, parathyroid hormone, and calcium. Moreover, we observed a dramatic improvement in her AD severity with VD treatment. This case demonstrates the complex interaction between VD deficiency, AD, and food allergy. We advise a high index of suspicion of VD deficiency rickets in children of all ages with AD, particularly during accelerated growth periods and in the presence of other risk factors such as darker skin, living at high latitude, sun avoidance, and low intake of VD-rich foods. The concomitant improvement in bone-related parameters and AD severity may reflect a double benefit of VD treatment, a possibility that warrants research on VD as potential treatment for AD.

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“…12 Previous studies have shown that vitamin D can be given as a protective therapy to reduce the severity of AD. 10,19,20 The American Academy of Pediatrics (AAP) recommends giving 400 IU of vitamin D as a supplement to newborns to prevent vitamin D deficiency. 5 In conclusion, there is a moderate correlation between serum 25-hydroxyvitamin-D level and SCORAD index in children with atopic dermatitis.…”

Section: Resultsmentioning

confidence: 99%

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Munawwarah¹,

Evalina²,

Sofyani³

2018

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Background Vitamin D plays an important role in the immune system. It inhibits B-lymphocyte proliferation and modulates the humoral response to suppress IgE production. Studies on the relationship between serum 25-hydroxyvitamin-D level and the severity of atopic dermatitis in several countries have had varying results. Objective To assess for a possible correlation between serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children. Methods A cross-sectional study was conducted in 26 children with atopic dermatitis from September to December 2015. We evaluated the severity of disease using the Scoring of Atopic Dermatitis

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Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

Abstract: These data suggest that vitamin D deficiency may be related to the severity of AD and advocate the need for studies evaluating the use of vitamin D as a potential treatment in patients with this disease.

Cited by 222 publications

References 36 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

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