Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

Abstract

This study investigated changes in the level of serum 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhongshan Hospital and 347 healthy people with physical examination (control group). The height and weight of all subjects were measured, and BMI was calculated. Fasting venous blood was extracted for the determination of blood glucose, blood lipid and 25(OH)D. The indicator levels of patients in the two groups were compared and analyzed. Spearman's correlation analysis was used to investigate the correlation between the severity of NAFLD and the level of 25(OH)D. The levels of BMI, FPG, FPI, HbA1c, TG, TC and LDL-C of patients in the NAFLD group were significantly higher than those in control group (P<0.05). The level of 25(OH)D in the NAFLD group was lower than that in control group (P<0.05). There was a significant negative correlation between 25(OH)D and the severity of patients in the NAFLD group (r=-0.868, P<0.001). BMI, FPG, FPI, HbA1c, TG, TC and LDL-C were independent risk factors for the low level of 25(OH)D (P<0.05). Lowly expressed in the serum of NAFLD patients, 25(OH)D has a significant negative correlation with the severity of NAFLD, which is of guiding significance for the prevention and treatment. 25(OH)D is a novel biomarker for NAFLD diagnosis and a potential drug target. Patients and methodsPatient data. A retrospective analysis was performed on 385 NAFLD patients admitted to the Zhongshan Hospital Affiliated to Xiamen University (Xiamen, China) from January 2015 to December 2017 and 347 healthy people with physical examination. There were 385 NAFLD patients in the NAFLD group, including 237 males and 148 females, aged

Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

“…More and more studies had shown that the low levels of vitamin D were closely related to the occurrence and development of NAFLD [ 13 , 25 , 26 ]. Lai et al [ 27 ] found that compared with healthy control group, the levels of 25-(OH) D were significantly lower in NAFLD patients,especially in patients with moderate and severe NAFLD. Yang et al [ 13 ] also found that serum 25-(OH) D decreased significantly in patients with liver fibrosis.…”

Development of a simple nonalcoholic fatty liver disease scoring system indicative of metabolic risks and insulin resistance

“…Furthermore, glycosylated hemoglobin type A1C was found not to be significantly associated with the presence of NAFLD. A previous study from China has reported that glycosylated hemoglobin level is not significantly different between healthy and mild NAFLD groups, but it significantly increased in moderate and severe NAFLD groups, suggesting that the glycosylated hemoglobin is still important in terms of NAFLD and needs to be considered especially when evaluating the severity of NAFLD (27).…”

Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

“…More and more studies had shown that the low levels of vitamin D were closely related to the occurrence and development of NAFLD [12,24,25].Lai et al [26] found that compared with healthy control group, the levels of 25-(OH)D were signi cantly lower in NAFLD patients,especially in patients with moderate and severe NAFLD. Yang et al [12] also found that serum 25-(OH)D decreased signi cantly in patients with liver brosis.…”