Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer’s disease

Zhang, Ziyi; Kwapong, William Robert; Cao, Le; Feng, Zijuan; Liu, Peng; Wang, Ruilin; Wu, Bo; Zhang, Shuting

doi:10.1007/s10072-023-07256-z

Neurol Sci

2024

DOI: 10.1007/s10072-023-07256-z

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Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer’s disease

Ziyi Zhang,

William Robert Kwapong,

Le Cao

et al.

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Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease

Sánchez-Puebla,

de Hoz,

Salobrar-García

et al. 2024

IJMS

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In Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APPNL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APPNL-F/NL-F-model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APPNL-F/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.

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Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease

Sánchez-Puebla,

de Hoz,

Salobrar-García

et al. 2024

IJMS

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show abstract

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Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer’s disease

Cited by 1 publication

References 46 publications

Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease

Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease

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