Correlation Between Serum Ferritin And Liver Function in Thalassemia Patients

Abstract

Thalassemia ,is one of the most important hemolytic genetic, diseases that break down red blood cells, Children with thalassemia cannot produce. enough hemoglobin because; the bone marrow cannot produce enough red blood cells to meet their needs and the red blood cells produced ,by them are almost devoid of hemoglobin, and the disease is divided into alpha, and Beta thalassemia.The current study was designed with the aim of .investigating the relationship between serum ferritin and hepatic enzymes in thalassemia. patients, iron is stored primarily in the form of ,ferritin in liver cells. The study included 60 patients with thalassemia in; Dhi Qar governorate, distributed between. the two gender during the, research period, their ages ranged between (2 -26) years old, blood samples were taken in order to testing of. hemoglobin, ferritin, and liver enzymes (ATP, GOT, GPT) , and the same, tests were performed on healthy people 40 person ;as they are a control group.The results recorded; a high percentage of ,thalassemia incidence in males and a decrease in females. The study also showed; that the incidence of thalassemia reached its peak in the age. group (2-6) years and decreased with age, as it reached its lowest levels in the age, group (22-26) years.The study revealed .a significant decrease (0.05> P) in hemoglobin concentration in thalassemia, patients compared with the ;control group, and the results recorded a significant; increase (0.05 P <) in the concentration of ferritin in thalassemia, patients compared with the control group.The current study; also showed a significant increase (P <0.05) in GPT enzyme concentration in thalassemia. patients compared with the control group. There was a significant increase (P <0.05) of GOT enzyme; concentration in patients compared to the ,control group.The results indicated. that there was a significant increase (P <0.05) in the concentration of the ALP enzyme in the patients. compared with the control group.