Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants

Lúðvíksson, Björn Rúnar; Eiríksson, T. H.; Árdal, Björn; Sigfússon, Ásbjörn; Valdimarsson, H.

doi:10.1016/s0022-3476(05)82535-1

Cited by 73 publications

(63 citation statements)

References 16 publications

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“…She was MBL deficient (< 10 ng/ml) and her serum IgA at 0.37 mg/ml was in the lower range for her age (0.2-1.44 mg/ml) [39]. Other immunological parameters were normal.…”

Section: Methodsmentioning

confidence: 94%

Reconstitution of Opsonizing Activity by Infusion of Mannan‐Binding Lectin (MBL) to MBL‐Deficient Humans

Valdimarsson¹,

et al. 1998

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Reconstitution ofOpsonizing Activity by Infusion of Mannan-Binding Lectin (MBL) to MBL-Deficient Humans. Scand J Immunol 1998;48:116-123 Mannan-binding lectin (MBL, previously named mannan-binding protein, MBP) is a serum collectin, which activates complement upon binding to microbial carbohydrates. This results in opsonization of the microorganisms as well as direct complement-mediated killing. Clinical evidence indicates that MBL has an important role in the innate immune defence against various pathogens. Genetically determined MBL deficiency is associated with increased susceptibility to infections. We have infused two MBL-deficient individuals with clinical grade MBL, purified from pooled donor plasma, in doses sufficient to attain normal concentration of MBL in serum. This resulted in normalization of complement-mediated opsonization. An initial rapid decrease in the serum concentration of MBL was followed by a slower decline with an estimated half-life of about 6 days. No adverse effects were observed and anti-MBL antibodies could not be detected following several MBL infusions. One of the two MBL recipient, a two-year-old girl, who had been suffering from repeated infections from the age of 4 months, was given a total of six MBL infusions. She has subsequently remained healthy for more than three years.

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“…She was MBL deficient (< 10 ng/ml) and her serum IgA at 0.37 mg/ml was in the lower range for her age (0.2-1.44 mg/ml) [39]. Other immunological parameters were normal.…”

Section: Methodsmentioning

confidence: 94%

Reconstitution of Opsonizing Activity by Infusion of Mannan‐Binding Lectin (MBL) to MBL‐Deficient Humans

Valdimarsson¹,

et al. 1998

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“…Classical studies had proposed that IgG and IgA [29] increase during immu notherapy with allergen and act as 'blocking antibodies' to the allergic response. Protective functions of IgA in allergy are also suggested by the increased incidence of atopic man ifestations in children with IgA deficiency [30],…”

Section: Discussionmentioning

confidence: 99%

Effects of Cyclosporine and Dexamethasone on IgE Antibody Response in Mice, and on Passive Cutaneous Anaphylaxis in the Rat

Puignerö¹,

Salgado²,

Queralt³

1995

Int Arch Allergy Immunol

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The suppressive effects of cyclosporine A (CsA) and dexamethasone (Dxt) on antigen-specific IgE responses to ovalbumin (OA) were studied in BALB/c mice. The effects upon other isotypes were also analyzed. The antiovalbumin IgE response did not change when low doses of CsA [8 mg/kg intraperitoneally (i.p.)] were administered; IgA also remained unchanged, while IgG and IgG1 decreased significantly. At higher CsA doses (16 mg/kg i.p. or orally), a decrease was noted for all the ispotypes assayed. Dxt administered orally at 0.3 mg/kg selectively inhibited IgE and IgA but did not influence IgG or IgG1 levels. Delayed hypersensitivity reactions to OA were not modified by CsA, but were depressed by Dxt. Although CsA had not effect on passive cutaneous anaphylaxis in the rat, Dxt significantly reduced this reaction when it was administered 6 h before challenge. These results suggest that Dxt has more specific antiallergic activity than CsA.

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“…Atopy has been shown to be more common in blood donors with IgA deficiency than healthy individuals (Kaufman and Hobbs 1970), while IgE concentrations are often increased in patients with selective IgA deficiency (Buckley and Fiscus 1975). Furthermore, selective IgA deficiency can be a risk factor for atopy in childhood (Ludviksson et al 1992), with most common allergic disorders reported being allergic conjunctivitis, rhinitis, urticaria, eczema, and bronchial asthma (Plebani et al 1987). In addition, bronchial hyperresponsiveness is more prominent in patients with selective IgA deficiency compared with healthy non-atopic controls (Papadopoulou et al 2005).…”

Section: Aberrant B Cell Development and Allergymentioning

confidence: 99%

B Cells: From Early Development to Regulating Allergic Diseases

Samitas

Lötvall

Bossios

2010

Arch. Immunol. Ther. Exp.

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B lymphocytes are characterized by a unique and highly specialized developmental pathway that is responsible for their vast phenotypic and function diversity. B cell development is strictly regulated to ensure sufficient specific humoral immunity while at the same time avoiding any errors that would compromise B cell functionality. The generation and maintenance of mature B cells from the constant flux of bone marrow progenitors is a complex process that is generally poorly understood, although great progress has been made in recent years. B cells have for long been considered mainly as antibody-producing cells and therefore believed to play an important role in the pathophysiology of allergic diseases, primarily through their ability to produce IgE antibodies. However, recent findings have revealed new aspects of their role in immune responses that place them again under the spotlight as important immune regulators, independent of antibody production. This review focuses on the developmental processes responsible for the numerous phenotypes and functions of the B-lymphocyte pool and the different aspects of effector B cell functionality in the context of allergy.

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Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants

Cited by 73 publications

References 16 publications

Reconstitution of Opsonizing Activity by Infusion of Mannan‐Binding Lectin (MBL) to MBL‐Deficient Humans

Reconstitution of Opsonizing Activity by Infusion of Mannan‐Binding Lectin (MBL) to MBL‐Deficient Humans

Effects of Cyclosporine and Dexamethasone on IgE Antibody Response in Mice, and on Passive Cutaneous Anaphylaxis in the Rat

B Cells: From Early Development to Regulating Allergic Diseases

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