Correlation between Spectral Domain Optical Coherence Tomography and Microperimetric Findings before and after Intravitreal Bevacizumab Injection in Wet Age Related Macular Degeneration

Abstract

Purpose: To evaluate Microperimetry and Optical Coherence Tomography (OCT) in correlating macular structure/function, location/stability of fixation and preferred retinal loci (PRL) before and after bevacizumab injection in wet Age Related Macular degeneration (AMD).Methods: 30 eyes with wet AMD underwent OCT and microperimetry before receiving bevacizumab and one month after treatment. Topography/ Microperimetry overlay was used to assess macular thickness/sensitivity and Location/stability. Results:There was statistically significant improvement in macular thickness and best corrected visual acuity (BCVA) but improvement in macular sensitivity was not significant. There was significant positive correlation between baseline visual acuity (VA) ≤ 3/60 and change in VA. No significant correlation between improvement in macular thickness and change in macular sensitivity. No significant correlation between improvement in VA and improvement in macular sensitivity. Conclusion:Microperimetry is an important tool in evaluating macular structure and function, location/stability of fixation and PRL in wet AMD.