Correlation between syndrome differentiation and CT quantitative diagnosis of fatty liver

Abstract

Syndrome differentiation of fatty liver is correlated with CT quantitative diagnosis, which can be discriminated by the ratio of liver-spleen.

Effect of elevated serum ferritin on the risk of death in patients with decompensated cirrhosis: a meta-analysis

“…High serum ferritin was associated with an increased risk of death in patients with decompensated cirrhosis, according to three studies that provided data on univariate analysis [18,23,24], with a pooled unadjusted HR of 2.38 (95% CI, 1.78–3.18). The level of heterogeneity was low ( I 2 = 17.4%, P = 0.298) (Fig.…”

“…Subsequently, we excluded the following studies: three studies that did not specifically report the outcome measure of interest; 29 studies that did not indicate that the patients were in the decompensated stage of cirrhosis; eight studies had a sample size of less than 100; eight studies were published in meeting abstracts. Finally, a total of eight studies were included in our meta-analysis [16][17][18][20][21][22][23][24].…”

“…Data on the prevalence of elevated serum ferritin were available in eight studies [16][17][18][20][21][22][23][24], with a pooled prevalence of 40.6% (95% CI, 32.1-49.2%) (Fig. 2).…”

“…The sensitivity analysis was carried out by omitting a single study per step, and the results showed that the pooled unadjusted HR in each step did not change substantially, indicating that our pooled result was robust to some extent (Supplementary Figure S7, Supplemental digital content 1, http://links.lww.com/ EJGH/A869). A total of five studies reported data on multivariate analysis [16][17][18]23,24], with elevated serum ferritin associated with increased mortality having a pooled adjusted HR of 1.44 (95% CI, 0.99-2.10). The result was not statistically significant, and the heterogeneity among the included studies was high (I 2 = 88.8%, P = 0.000) (Supplementary Figure S8, Supplemental digital content 1, http://links.lww.com/EJGH/A869); however, subgroup analysis by the cut-off value of serum ferritin demonstrated that intra-group heterogeneity was low in both the serum ferritin = 200 ng/ml group (I 2 = 0.0%, P = 0.355) and the serum ferritin > 200 ng/ml group (I 2 = 0.0%, P = 0.973), and a pooled adjusted HR in patients with serum ferritin = 200 ng/ml group was 1.545 (95% CI, 1.295-1.844) (Fig.…”

“…5). The sensitivity analyses (Supplementary Figure S9, Supplemental digital content 1, http://links.lww.com/ EJGH/A869) which excluded one study at a time, such as Guo 2022 [24], Maiwall 2014 [16], and Wang 2022 [23], and then pooled the remaining studies, revealed that the pooled adjusted HR was statistically insignificant; however, sensitivity analyses omitting one study sequentially at a time, such as Tornai 2021 [18] and Oikonomou 2017 [17], showed that the pooled adjusted HR was statistically significant.…”