Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes

Inoue, Minoru; Maehata, Eisuke; Yano, Masao; Taniyama, Matsuo; Suzuki, Seiji

doi:10.1016/j.metabol.2004.09.006

Cited by 152 publications

(138 citation statements)

References 29 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…However, both leptin and adiponectin are produced by adipose tissue and it has been suggested that leptin relative to adiponectin concentrations is a better marker of insulin resistance than these factors in single. 48,49 This was supported in our study by that the leptin/adiponectin ratio was more strongly related to Cpeptide and glucose markers than was each of the factors. Strengths of our study include the use of a well-defined population-based cohort, linkage to a cancer registry with a virtually complete coverage of cancer diagnoses and the use of a wide range of components related to the MetS.…”

Section: 4supporting

confidence: 76%

Components of the metabolic syndrome and colorectal cancer risk; a prospective study

et al. 2007

View full text Add to dashboard Cite

Objective: To examine the relation of well-known factors of the metabolic syndrome (MetS) as well as related circulating factors, with risk of colorectal cancer. Methods: We performed a case control study of 306 colorectal cancer cases and 595 matched controls nested in the Northern Sweden Health and Disease Cohort. Levels of C-peptide, glycated haemoglobin (HbA1c), leptin and adiponectin were measured in cryopreserved samples. Body mass index (BMI), systolic and diastolic blood pressure and fasting and post-load plasma glucose, had been measured in a subcohort. Conditional logistic regression was used to calculate odds ratios (OR) of disease, including risk assessments for the MetS factors: obesity (BMI430 kg m À2 ), hypertension (blood pressure X140/90 mmHg or use of anti-hypertensive drugs) and hyperglycaemia (fasting glucose X6.1 mmol l À1 or post-load glucose in capillary plasma X8.9 mmol l À1 ). Results: None of the studied variables were significantly associated with risk across quartiles. Presence of obesity, hypertension and hyperglycaemia significantly increased the risk of colorectal cancer; OR for three vs null factors was 2.57 (95% Confidence Interval [CI] 1.20-5.52; P trend ¼ 0.0021), as compared to a 30 to 70% increased risk for the factors in single. Similarly, top decile levels of C-peptide, HbA1c and leptin/adiponectin ratio were associated with an increased risk; ORs for top vs deciles 1-9 were 1.56 (95% CI 0.93-2.62; P ¼ 0.090), 1.83 (95% CI 1.00-3.36; P ¼ 0.051) and 1.50 (95% CI 0.83-2.71; P ¼ 0.18), respectively. Conclusions: Our study support the view that components of the MetS increase risk of colorectal cancer, and further suggests that only very high levels of metabolic factors confer an increased risk.

show abstract

Section: 4supporting

confidence: 76%

Components of the metabolic syndrome and colorectal cancer risk; a prospective study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Moreover, in other pathophysiological states the adiponectin/leptin interactions play a role; the ratio was used by several authors as a marker of risk for insulin resistance in DM2 [41], preclinical atherosclerosis [42], and, recently, also as potential marker of depression [43].…”

Section: Discussionmentioning

confidence: 99%

Leptin and adiponectin in pancreatic cancer: connection with diabetes mellitus

Krechler¹,

Zeman²,

Vecka³

et al. 2011

neo

View full text Add to dashboard Cite

The aim of this study was to analyze the relationship of serum leptin as well as adiponectin and the manifestation of pancreatic cancer (PC). Serum leptin, adiponectin, glucose homeostasis and insulin resistance (expressed as HOMA-IR) were investigated in 64 patients with newly diagnosed PC and compared with 64 healthy controls (CON group) and 75 patients with type 2 diabetes (DM2).Seventy percent of newly diagnosed PC patients had DM2. The levels of leptin were lower, whilst adiponectin/leptin ratio was higher in PC patients (both with and without DM2), in comparison with CON and DM2 groups (P < 0.001) independently of age, BMI and waist circumference.Newly diagnosed PC is characterized with lower leptin concentrations and higher adiponectin/leptin ratio in comparison with CON or DM2 individuals. Analysis of these parameters could help in the screening of persons in high risk for PC, especially in those with DM2.

show abstract

“…2 More recently, the evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. [3][4][5] We investigated, therefore, the relationship among L:A ratio, intima media thickness (IMT), and other cardiometabolic parameters in healthy males.…”

mentioning

confidence: 99%

Leptin:Adiponectin Ratio Is an Independent Predictor of Intima Media Thickness of the Common Carotid Artery

Norata

Raselli

Grigore

et al. 2007

Stroke

172

107

View full text Add to dashboard Cite

Background and Purpose-The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. Methods-We investigated, therefore, the relationship between L:A ratio and intima media thickness (IMT), an independent predictor of cardiovascular disease, in 110 healthy males. Results-L:A ratio was significantly correlated to body mass index, waist, hip, waist-to-hip ratio, systolic blood pressure, IMT, high-density lipoprotein, apolipoprotein A-I, glucose, and the homeostasis model of insulin resistance-revised. No significant correlation was observed with age, diastolic blood pressure, low-density lipoprotein, triglycerides, apolipoprotein B, ApoB/ApoA-I ratio, insulin, alanine transaminase, ␥-glutamyl-transferase, and resistin. In addition, when the relationship between IMT and adiponectin or leptin alone was analyzed, only leptin plasma levels significantly associated with IMT (rϭ0.301, PϽ0.01). In a multiple regression analysis including in the statistical model the risk factors known to affect IMT (age, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, triglycerides, total cholesterol, body mass index, glucose, and L:A ratio), we observed that only age, L:A, and glucose were independent predictors of IMT. As expected, obese subjects (body mass index Ͼ30 kg/m 2 ) showed a significantly higher L:A ratio compared with nonobese subjects (1.20 versus 0.42, respectively, PϽ0.001); in addition, subjects with the metabolic syndrome showed a significantly higher L:A ratio level (0.79) compared with subjects without (0.52) (PϽ0.01). Conclusions-We show here that the L:A ratio is a powerful independent predictor of IMT in healthy subjects and correlates with several anthropometric, metabolic, and clinical parameters better than each single adipokine. (Stroke.

show abstract

Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes

Cited by 152 publications

References 29 publications

Components of the metabolic syndrome and colorectal cancer risk; a prospective study

Components of the metabolic syndrome and colorectal cancer risk; a prospective study

Leptin and adiponectin in pancreatic cancer: connection with diabetes mellitus

Leptin:Adiponectin Ratio Is an Independent Predictor of Intima Media Thickness of the Common Carotid Artery

Contact Info

Product

Resources

About