Correlation Between the Cerebral Oxyhaemoglobin Signal and Physiological Signals During Cycling Exercise: A Near-Infrared Spectroscopy Study

Tsubaki, Atsuhiro; Takai, Haruna; Oyanagi, Keiichi; Kojima, Sho; Tokunaga, Yuta; Miyaguchi, Shota; Sugawara, Kazuhiro; Sato, Daisuke; Tamaki, Hiroyuki; Onishi, Hideaki

doi:10.1007/978-3-319-38810-6_21

Cited by 9 publications

(14 citation statements)

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“…A correlation between MAP and [O 2 Hb] (or StO 2 ) has been reported in various functional studies [ 89 , 98 , 99 ]. Tsubaki et al investigated the relationships between NIRS signals and MAP during exercises on a bicycle ergometer [ 100 ]. They found highly significant correlations between MAP and [O 2 Hb] during warm-up and at workloads corresponding to 30 and 50% of peak oxygen consumption [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tsubaki et al investigated the relationships between NIRS signals and MAP during exercises on a bicycle ergometer [ 100 ]. They found highly significant correlations between MAP and [O 2 Hb] during warm-up and at workloads corresponding to 30 and 50% of peak oxygen consumption [ 100 ]. In another recent study, in contrast, a non-significant association between StO 2 and MAP was observed in critically ill adults [ 101 ].…”

Section: Discussionmentioning

confidence: 99%

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Individual Differences in Hemodynamic Responses Measured on the Head Due to a Long-Term Stimulation Involving Colored Light Exposure and a Cognitive Task: A SPA-fNIRS Study

2021

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When brain activity is measured by neuroimaging, the canonical hemodynamic response (increase in oxygenated hemoglobin ([O2Hb]) and decrease in deoxygenated hemoglobin ([HHb]) is not always seen in every subject. The reason for this intersubject-variability of the responses is still not completely understood. This study is performed with 32 healthy subjects, using the systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) approach. We investigate the intersubject variability of hemodynamic and systemic physiological responses, due to a verbal fluency task (VFT) under colored light exposure (CLE; blue and red). Five and seven different hemodynamic response patterns were detected in the subgroup analysis of the blue and red light exposure, respectively. We also found that arterial oxygen saturation and mean arterial pressure were positively correlated with [O2Hb] at the prefrontal cortex during the CLE-VFT independent of the color of light and classification of the subjects. Our study finds that there is substantial intersubject-variability of cerebral hemodynamic responses, which is partially explained by subject-specific systemic physiological changes induced by the CLE-VFT. This means that both subgroup analyses and the additional assessment of systemic physiology are of crucial importance to achieve a comprehensive understanding of the effects of a CLE-VFT on human subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Individual Differences in Hemodynamic Responses Measured on the Head Due to a Long-Term Stimulation Involving Colored Light Exposure and a Cognitive Task: A SPA-fNIRS Study

2021

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“…Furthermore, previous studies revealed exercise-induced activations in prefrontal cortex (PFC) showing that Hb and HHb levels respond as a function of both exercise load and duration in both experts (Rupp et al 2008) and non-experts (Auger et al 2016; Giles et al 2014; Jung et al 2015). However, previous studies focusing on neurovascular coupling at several intensity levels show that there is no consensus concerning the type of exercise (incremental tests with short stages vs. constant-load exercises), duration of exercise (Giles et al 2014; Tsubaki et al 2016) and intensity (Auger et al 2016; Byun et al 2014; Giles et al 2014; Takehara et al 2017; Tsubaki et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Changes in neurovascular coupling during cycling exercise measured by multi-distance fNIRS: a comparison between endurance athletes and physically active controls

et al. 2019

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It is well known that endurance exercise modulates the cardiovascular, pulmonary, and musculoskeletal system. However, knowledge about its effects on brain function and structure is rather sparse. Hence, the present study aimed to investigate exercise-dependent adaptations in neurovascular coupling to different intensity levels in motor-related brain regions. Moreover, expertise effects between trained endurance athletes (EA) and active control participants (ACP) during a cycling test were investigated using multi-distance functional near-infrared spectroscopy (fNIRS). Initially, participants performed an incremental cycling test (ICT) to assess peak values of power output (PPO) and cardiorespiratory parameters such as oxygen consumption volume (VO2max) and heart rate (HRmax). In a second session, participants cycled individual intensity levels of 20, 40, and 60% of PPO while measuring cardiorespiratory responses and neurovascular coupling. Our results revealed exercise-induced decreases of deoxygenated hemoglobin (HHb), indicating an increased activation in motor-related brain areas such as primary motor cortex (M1) and premotor cortex (PMC). However, we could not find any differential effects in brain activation between EA and ACP. Future studies should extend this approach using whole-brain configurations and systemic physiological augmented fNIRS measurements, which seems to be of pivotal interest in studies aiming to assess neural activation in a sports-related context.

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“…The timepoint of significant increase in the O 2 Hb and THb were 50-60% during incremental exercise, while the SBF was 70% during incremental exercise (Figure 3). Moreover, previous studies reported none or negative correlation between the SBF and O 2 Hb at high intensity exercise and cool-down (Tsubaki et al, 2016;Kojima et al, 2021). Although SBF and O 2 Hb appear to increase simultaneously, we considered that changes in cerebral oxygenation were related to increased cerebral blood flow or cortical activation.…”

Section: Cerebral Oxygenation During Incremental Exercisementioning

confidence: 97%

Temporal changes in cortical oxygenation in the motor-related areas and bilateral prefrontal cortex based on exercise intensity and respiratory metabolism during incremental exercise in male subjects: A near-Infrared spectroscopy study

et al. 2022

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A recent study has reported that prefrontal cortex (PFC) activity during incremental exercise may be related to exercise termination on exhaustion. However, few studies have focused on motor-related areas during incremental exercise. This study investigated changes in the oxygenation of the PFC and motor-related areas using near-infrared spectroscopy during incremental exercise. Moreover, we analyzed the effect of exercise termination on changes in cortical oxygenation based on exercise intensity and respiratory metabolism. Sixteen healthy young male patients participated in this study. After a 4-min rest and 4-min warm-up period, incremental exercise was started at an incremental load corresponding to 20 W/min. Oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), and total hemoglobin (THb) in the bilateral PFC, supplementary motor area, and primary motor cortex were measured. We evaluated changes in oxygenation in each cortex before and after the anaerobic threshold (AT) and respiratory compensation point to identify changes due to respiratory metabolism. O2Hb and THb increased from moderate intensity or after AT to maximal exercise, and HHb increased slowly compared to O2Hb and THb; these changes in hemoglobin levels were consistent in all cortical areas we measured. However, the increase in each hemoglobin level in the bilateral PFC during incremental exercise was faster than that in motor-related areas. Moreover, changes in cortical oxygenation in the right PFC were faster than those in the left PFC. These results suggest changes based on differences in neural activity due to the cortical area.

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Correlation Between the Cerebral Oxyhaemoglobin Signal and Physiological Signals During Cycling Exercise: A Near-Infrared Spectroscopy Study

Cited by 9 publications

References 13 publications

Individual Differences in Hemodynamic Responses Measured on the Head Due to a Long-Term Stimulation Involving Colored Light Exposure and a Cognitive Task: A SPA-fNIRS Study

Individual Differences in Hemodynamic Responses Measured on the Head Due to a Long-Term Stimulation Involving Colored Light Exposure and a Cognitive Task: A SPA-fNIRS Study

Changes in neurovascular coupling during cycling exercise measured by multi-distance fNIRS: a comparison between endurance athletes and physically active controls

Temporal changes in cortical oxygenation in the motor-related areas and bilateral prefrontal cortex based on exercise intensity and respiratory metabolism during incremental exercise in male subjects: A near-Infrared spectroscopy study

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