Correlation Between the Crohn's Disease Activity and Harvey–Bradshaw Indices in Assessing Crohn's Disease Severity

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

“…Current disease activity was determined based on standardized clinical indices obtained during the clinical interview, using the Harvey-Bradshaw for Crohn's disease (CD) and the Powell-Tuck for ulcerative colitis (UC) (31,32). Cut off levels of >5 were used to identify active IBD (33,34).…”

Long‐term safety and efficacy of certolizumab pegol in the treatment of Crohn's disease: 7‐year results from the PRECiSE 3 study

“…In PRECiSE 1 and 2, data for CDAI and the HarveyBradshaw Index (HBI) were collected, and the correlation between two indexes was established. 22 In PRECiSE 3, efficacy was assessed using the HBI.…”

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

“…As such, lack of an appropriate reference investigation with a longitudinal track record thus necessitated the distinction between responders and non-responders on the basis of a clinically meaningful response, i.e. an HBI drop of 3 or more between the baseline and follow-up visits 27 . In planning future studies, an alternative strategy could be the use of a consensus panel (including other markers such as CRP and FC) to determine the response status of each individual patient.…”

“…9/13 patients who completed PET scanning both at baseline and a median [range] of 12 [11][12][13][14][15][16][17][18] weeks after initiation of anti-TNF treatment had favourable clinical responses 27 (median [range] responder ΔHBI = 5 [3][4][5][6][7][8][9]; non-responder ΔHBI = 1[-1-2]), (Table 1). …”

“…For all these correlations, the Spearman rank correlation coefficient was also used. We also performed an ordinal analysis after classifying patients as either responders or non-responders on the basis of the clinical response 3 months after the initiation of therapy (a decrease in HBI of >3 points) 27 .…”