Correlation Between the Myopic Retinal Deformation and Corneal Biomechanical Characteristics Measured With the Corvis ST Tonometry

Abstract

Purpose We previously reported that the retinal deformation due to myopia was represented by the peripapillary retinal arteries angle (PRAA). In this study, we investigated the relationship between the PRAA and biomechanical properties measured with Corvis ST (CST) tonometry. Methods Thirty-four normative eyes of 34 subjects who underwent CST measurement were enrolled. The PRAA was calculated from a fundus photograph. Variables related to the PRAA were identified from age, axial length, spherical equivalent refractive error, and 10 CST parameters using model selection with the second-order bias-corrected Akaike information criterion index. Results The PRAA was best described with axial length (coefficient = −5.66, P < 0.0001), maximum deflection amplitude (mm; coefficient = 130.5, P = 0.0004), and deflection amplitude ratio (DA ratio) 2 mm (coefficient = −25.8, P = 0.0032), where mm was the amount of the maximum corneal apex movement and DA ratio 2 mm was the ratio between the deformation amplitudes at the apex and 2 mm away from the apex. The optimal model was significantly better than the model only with axial length ( P = 0.0014, analysis of variance). Conclusions The PRAA was significantly better described with the CST parameters compared to the axial length model only; eyes with small PRAA (larger myopic retinal deformation) showed narrow and shallow maximum corneal deflection. Translational Relevance The Corvis ST parameters, which represents corneal biomechanical characteristics, were associated with myopic retinal deformation.

Unraveling the mechanobiology of cornea: From bench side to the clinic

“…In a meta-analysis of corneal biomechanical properties of 11 related studies using an ocular response analyzer, we found that corneal elasticity decreased significantly in high myopia ( Wu et al, 2019 ). We further showed that corneal stiffness of over 1,000 patients with high myopia provided by Corvis ST also significantly reduced ( Han et al, 2020 ), which is further supported by the findings from other groups ( Zhang et al, 2018 ; Asano et al, 2019 ; Long et al, 2019 ; Kenia et al, 2020 ; Sedaghat et al, 2020 ; Tubtimthong et al, 2020 ). With an experimentally induced myopia model in chicks, the reduction of corneal elasticity and weakness of corneal biomechanics were related to development of myopia ( Kang et al, 2018 ).…”

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position

“…We previously reported that a narrow PRAA is related to poor damping capacity of an eye as measured with the Ocular Response Analyzer (Reichert Technologies, Depew, NY, USA) or OCULUS Corvis STL (Oculus, Inc., Menlo Park, CA, USA). 54,55 Such damping capacity of an eye has been reported to be associated with the development and progres-sion of glaucoma and other retinal diseases such as angioid streaks. [56][57][58] We have speculated that eyes are deformed even in daily life activities, such as postural changes, eyelid blinking, ocular pulsatility due to ocular hemodynamics, performing the Valsalva maneuver, and regular eye movement.…”

The Relationship Between Optic Disc and Retinal Artery Position and Glaucomatous Visual Field Progression

“…We previously reported that the angle between the supratemporal and infratemporal peaks in the profile of the circumpapillary retinal nerve fiber layer RNFL (cpRNFL) narrows with the elongation of an eye, 11 and this is associated with alterations of the biomechanical properties of an eye. 12 – 14 Indeed, the cpRNFL peak angle can be accurately represented by the angle between supratemporal and infratemporal major retinal arteries (correlation coefficient equal to 0.92). 11 We also reported that correcting the cpRNFL thickness profile using the positions of the major retinal arteries significantly improved the structure-function association between cpRNFL thickness and VF sensitivity.…”