Correlation between the occurrence of lupus nephritis, anti‐erythrocyte autoantibodies and V_x haplotype in NZB × 129/J and NZB × SM/J recombinant inbred murine strains

Abstract

The NZB mouse is genetically predisposed to the development of autoimmune disease that resembles the human autoimmune systemic lupus erythematosus and autoimmune hemolytic anemia, with increased titers of anti-DNA, and Coombs' autoantibodies. The various autoimmune traits are controlled separately by a limited number of genes. Genetic studies have shown that several immune loci are involved in autoimmunity: T cell abnormalities, H-2 complex and immunoglobulin genes have been implicated. In this report, we present evidence for a significant correlation of NZB V kappa 1 haplotype defined by restriction fragment length polymorphism analysis with anti-erythrocyte autoantibodies in NZB x 129/J and NZB x SM/J recombinant inbred lines.

Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient “viable motheaten” mice

“…Humans and experimental animals with autoimmune disease and concurrent anemia commonly have a hemolytic anemia secondary to anti-erythrocyte antibodies [2,[11][12][13]. Anemia in me v / me v mice was also postulated to be a consequence of anti-erythrocyte antibodies [8].…”