Correlation between the serum alkaline phosphatase level and the severity of coronary artery disease

Şahin, İrfan; Karabulut, Ahmet; Güngör, Barış; Avcı, İlhan İlker; Okuyan, Ertuğrul; Kızkapan, Fatih; Yıldız, Süleyman Sezai; Can, Mehmet Mustafa; Dinçkal, Mustafa Hakan

doi:10.1097/mca.0000000000000080

Cited by 21 publications

(27 citation statements)

References 3 publications

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“…ALP has been associated with the outcomes and prognoses of patients with cardiovascular disease and peripheral artery disease [8][9][10], and a study of 2029 acute stroke patients found that the mortality risk of patients with ALP levels>97 U/L was almost three times greater than that of those with ALP levels<57 U/L [17]. This difference is likely related to vascular smooth muscle calcification, which results in arteriosclerosis and precedes a series of brain impairments, including ischemic cerebral stroke, leukodystrophy, and intracranial hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Non-tissue specific ALP is expressed in various organs, including the liver, kidneys, and bone, and plays an important role in clinical diagnoses. For example, ALP levels are associated with the outcomes and prognoses of patients with cardiovascular disease and peripheral artery disease [8][9][10], and there is an association between ALP levels and lacunar infarctions. However, few studies have investigated the association between ALP and cognitive function in patients with SIVD.…”

Section: Biomedical Research 2018; 29 (1): 149-154mentioning

confidence: 99%

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Serum alkaline phosphatase is related to cognitive impairment in patients with subcortical ischemic vascular disease

Wang¹,

Ji²,

Jia³

et al. 2018

biomedicalresearch

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Background: The aim of the present study was to assess the relationship between serum levels of Alkaline Phosphatase (ALP) and cognitive impairments in patients with Subcortical Ischemic Vascular Disease (SIVD). Methods: This study included 235 patients who were assigned to a mild-cognitive-impairment group or a vascular-dementia group according to the severity of their cognitive impairments. The incidences of multiple lacunar infarctions and leukoaraiosis were confirmed using Magnetic Resonance Imaging (MRI) scans. Serum ALP was measured with an enzymatic method; the Mini-mental State Examination (MMSE) and the Cambridge Cognitive Examination-Chinese version (CAMCOG-C) were used to assess neuropsychological status; and a logistic regression was performed to explore the associations between ALP levels and cognitive impairments. Results: ALP levels were higher in the vascular-dementia group than in the control group (82.7 ± 15.06 vs. 68.4 ± 14.8, respectively), and scores on the MMSE and CAMCOG-C were significantly lower in the vascular-dementia than in the mild-cognitive-impairment group. Additionally, ALP levels were negatively correlated with MMSE and CAMCOG-C scores (r=-0.364 and r=-0.297, respectively). The incidences of lacunar infarction and leukoaraiosis were higher in the vascular-dementia group than in the mild-cognitive-impairment group (73.9% vs. 60.0% and 80.0% vs. 64.2%, respectively), and the logistic regression revealed that ALP levels were positively associated with cognitive impairments after adjusting for potential confounding factors (Odds Ratio (OR): 1.57, 95% Confidence Interval (CI): 1.14-2.17). Furthermore, the risk of cognitive impairments increased by 57% per unit of ALP change.

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Section: Discussionmentioning

confidence: 99%

Section: Biomedical Research 2018; 29 (1): 149-154mentioning

confidence: 99%

Serum alkaline phosphatase is related to cognitive impairment in patients with subcortical ischemic vascular disease

Wang¹,

Ji²,

Jia³

et al. 2018

biomedicalresearch

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“…These results have led to a focus on ALP in patients with CAD. Sahin et al showed that elevated ALP levels are associated with high Gensini scores and a more severe form of CAD (11) . However, whether ALP is associated with the extent and severity of CAD in AMI patients was unknown.…”

Section: Discussionmentioning

confidence: 99%

“…High serum ALP levels are an independent predictor of mortality, AMI, and stent thrombosis in CAD patients after percutaneous coronary intervention (PCI) with drug-eluting stents (10) . Elevated ALP levels were associated with more advanced forms of CAD in patients with stable angina pectoris (11) . To the best of our knowledge, the relationship between ALP and extent and severity of CAD in patients with AMI has not been evaluated previously.…”

Section: Introductionmentioning

confidence: 99%

Value of Alkaline Phosphatase in Predicting the Extent and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Kılıt¹

2017

Kosuyolu Heart Journal

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Introduction: The serum alkaline phosphatase (ALP) level has been shown to be a prognostic factor in stable coronary artery disease (CAD) and acute myocardial infarction (AMI) by its promoting effect on vascular calcification. The objectives of this study were to investigate serum ALP levels and to determine their value in predicting the extent and severity of CAD in patients with AMI. Patients and Methods:A total of 200 patients with AMI were included in this study. Patients with serum ALP levels higher than 120 mg/dL were classified as elevated ALP group. The extent and severity of CAD was assessed using Gensini score and number of vessel disease. Patients with a Gensini score greater than 40 were included in advanced CAD group.Results: There was no relationship between the ALP level and the Gensini score in study population. Patients were grouped according to the Gensini score (Gensini scores ≤ 40 and > 40). There was no difference between the groups in terms of ALP levels. However, ALP levels were significantly higher in diabetic patients and in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Parathormone levels and neutrophil counts were significantly higher in the advanced CAD group.Conclusion: ALP levels do not indicate the extent and severity of CAD in patients with AMI. However, these levels are higher in diabetic patients and in patients with NSTEMI than in patients with ST-segment elevation myocardial infarction. Higher parathormone levels and neutrophil counts are related to the extent and severity of CAD in patients with AMI.

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“…From the cardiovascular standpoint, ALP is best known for hydrolyzing pyrophosphate, an inhibitor of vascular calcification (1). Several reports have linked plasma ALP levels to adverse cardiovascular events: all cause and cardiovascular mortality (1); risk of mortality and of hospitalization (2); coronary heart disease risk (3); mortality, myocardial infarction and stent thrombosis after coronary angioplasty (4); severity of coronary artery disease (5).…”

Section: Introductionmentioning

confidence: 99%

Plasma alkaline phosphatase and survival in diabetic patients with acute myocardial infarction

Nunes

Melão

Godinho³

et al. 2016

Ann. Transl. Med.

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Background: Alkaline phosphatase (ALP) removes phosphate groups from many types of molecules. The aim of the present research was to study the relation between plasma ALP and survival in diabetic patients with myocardial infarction.Methods: Retrospective study: from 954 admissions (15 months period) in a coronary care unit, we selected 200 admissions corresponding to 195 patients with myocardial infarction and diabetes mellitus. Survival after no less than 48 months, and up to 61 months, after the myocardial infarction episode, was under study, in association with ALP levels.Results: A relatively weak but significant correlation was seen between the peak plasma cardiac troponin I and ALP levels (r: 0.21, significance level: 0.003). Using the median value for ALP as cut-off (74 IU/L), plasma creatinine was significantly higher in patients with higher values for ALP. Patients with elevated ALP had decreased survival in Kaplan-Meier analysis (significance level in log-rank test: 0.032). This finding was noted for male patients (significance level in log-rank test: 0.035), but not for female patients (significance level in log-rank test: 0.497).Conclusions: Elevated ALP acts as a prognostic indicator of decreased survival in diabetic patients with acute myocardial infarction, possibly in association to decreased renal function. This finding is limited to male patients, pointing to a possible different role for phosphatase activity in cardiovascular disease in male and female diabetic patients.

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Correlation between the serum alkaline phosphatase level and the severity of coronary artery disease

Abstract: Elevated ALP levels are associated with higher Gensini scores and a more severe form of CAD.

Cited by 21 publications

References 3 publications

Serum alkaline phosphatase is related to cognitive impairment in patients with subcortical ischemic vascular disease

Serum alkaline phosphatase is related to cognitive impairment in patients with subcortical ischemic vascular disease

Value of Alkaline Phosphatase in Predicting the Extent and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Plasma alkaline phosphatase and survival in diabetic patients with acute myocardial infarction

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