Correlation of Fetal Kidney and Testis Congenic Graft Survival With Reduced Major Histocompatibility Complex Burden

Statter, Mindy B.; Fahrner, Karen J.; Barksdale, Edward M.; Parks, Daniel E.; Donahoe, Patricia K.

doi:10.1097/00007890-198904000-00017

Cited by 46 publications

(46 citation statements)

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“…This is in marked contrast to the observation of Bellgrau and coworkers, who reported the indefinite survival of CD95L ϩ allogeneic testis tissue that appeared ''indistinguishable from syngeneic grafts'' (1). Our findings were therefore similar to those of Statter and coworkers, who found that in both the rat and the mouse, adult allogeneic testis grafts became massively infiltrated and suffered rejection by 10 days (18,19). We cannot account for the difference between our results and those of Bellgrau and coworkers (1).…”

Section: Discussionsupporting

confidence: 84%

“…Mice never became diabetic, however, implying either incomplete destruction or regenerative capacity of the islets. A number of mechanisms may have led to the ␤ cell damage seen in the high expresser line, including (i) the toxic effects of overexpressed transgenes (19), (ii) the damaging effects of the granulocytic infiltrate, or (iii) the possibility that CD95 was up-regulated on transgenic islets which then killed themselves.…”

Section: Discussionmentioning

confidence: 99%

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Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

Allison

Georgiou

Strasser

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

353

225

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

Allison

Georgiou

Strasser

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

353

225

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“…The role of Fas-FasL interaction in immunologic priv-has also been reported by others (386,387). Other attempts to exploit graft expression of FasL to ilege was first documented by the discovery that testis allografts survive indefinitely upon transplantation to allo-achieve transplantation tolerance in the absence of immunosuppression have also failed (64,163).…”

Section: B) Role Of Fas-fasl (Cd95-cd95l) In Immunologic Privi-supporting

confidence: 70%

“…Much research has centered on the use of fetal tissues other sites. First, extracellular fluid within these sites generally does not drain directly via lymphatics into lymph because they express lower levels of MHC antigens than do adult tissues (386). Because of the highly experimental nodes, the site where host immune responses are typically initiated.…”

Section: Immunologic Tolerance C Genesis Of the Concept Of Tranmentioning

confidence: 99%

Induction of Immunologic Tolerance for Transplantation

Rossini

Greiner

Mordes

1999

Physiological Reviews

121

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Rossini, Aldo A., Dale L. Greiner, and John P. Mordes. Induction of Immunologic Tolerance for Transplantation. Physiol. Rev. 79: 99–141, 1999. — In the second half of the 20th century, the transplantation of replacement organs and tissues to cure disease has become a clinical reality. Success has been achieved as a direct result of progress in understanding the cellular and molecular biology of the immune system. This understanding has led to the development of immunosuppressive pharmaceuticals that are part of nearly every transplantation procedure. All such drugs are toxic to some degree, however, and their chronic use, mandatory in transplantation, predisposes the patient to the development of infection and cancer. In addition, many of them may have deleterious long-term effects on the function of grafts. New immunosuppressive agents are constantly under development, but organ transplantation remains a therapy that requires patients to choose between the risks of their primary illness and its treatment on the one hand, and the risks of life-long systemic immunosuppression on the other. Alternatives to immunosuppression include modulation of donor grafts to reduce immunogenicity, removal of passenger leukocytes, transplantation into immunologically privileged sites like the testis or thymus, encapsulation of tissue, and the induction of a state of immunologic tolerance. It is the last of these alternatives that has, perhaps, the most promise and most generic applicability as a future therapy. Recent reports documenting long-term graft survival in the absence of immunosuppression suggest that tolerance-based therapies may soon become a clinical reality. Of particular interest to our laboratory are transplantation strategies that focus on the induction of donor-specific T-cell unresponsiveness. The basic biology, protocols, experimental outcomes, and clinical implications of tolerance-based transplantation are the focus of this review.

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“…Several mechanisms are thought to account for this observation (Hammerman, 2003), including absence of antigen-presenting cells within the metanephros prior to a certain stage in development (Foglia et al, 1986;Velasco and Hegre, 1989), reduced expression levels of major histo-STEM CELL APPROACHES FOR THE TREATMENT OF RENAL FAILURE compatibility class I and II antigens (Statter et al, 1989;Dekel et al, 1997), and altered expression levels of cytokines, chemokines, and cytolytic effector molecules relative to adult tissue (Dekel et al, 2000). Additionally, vascularization of transplanted metanephroi is accomplished, at least in part, by host blood vessels, resulting in the generation of a chimeric organ shielded to some degree from circulating immune-cell surveillance (Rogers and Hammerman, 2001b).…”

Section: B Renal Augmentationmentioning

confidence: 99%