Correlation of non-invasive oxygenation parameters with paO2/FiO2 ratio in patients with COVID-19 associated ARDS

Zaccagnini, Giacomo; Berni, Andrea; Pieralli, Filippo

doi:10.1016/j.ejim.2021.12.015

Cited by 9 publications

(4 citation statements)

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“…A recent study suggested that the SpO 2 /FiO 2 ratio as a more reliable and noninvasive alternative to the P/F ratio, particularly in situations where maintaining arterial catheterization becomes challenging due to thrombotic complications. 41 In another analysis of C-ARDS patients, it was observed that P/F, SpO 2 /FiO 2 , OI-P mean , and OSI-P mean values were associated with hospital mortality on both the third and seventh days after intubation, with the odds ratio being higher on the seventh day compared to the third day. 42 High OI-P mean and OSI-P mean values were found to be correlated with negative outcomes in both C-ARDS and non-C-ARDS patients, reinforcing their significance in clinical assessments.…”

Section: Discussionmentioning

confidence: 96%

“…40 Additionally, a strong correlation has been identified between P/F and SpO 2 /FiO 2 , both of which are commonly used for risk assessment and patient monitoring in intensive care settings. 40,41 These findings highlight the evolving landscape of diagnostic and prognostic tools in critical care medicine, emphasizing the need for ongoing research and evaluation of these parameters in diverse clinical contexts.…”

Section: Discussionmentioning

confidence: 96%

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Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power

Aşar,

Rahim,

Rahimi

et al. 2024

J Intensive Care Med

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Background: The oxygenation index (OI) and oxygen saturation index (OSI) are proven mortality predictors in pediatric and adult patients, traditionally using mean airway pressure (Pmean). We introduce novel indices, replacing Pmean with DP (ΔPinsp), MPdyn, and MPtot, assessing their potential for predicting COVID-19 acute respiratory distress syndrome (ARDS) mortality, comparing them to traditional indices. Methods: We studied 361 adult COVID-19 ARDS patients for 7 days, collecting ΔPinsp, MPdyn, and MPtot, OI-ΔPinsp, OI-MPdyn, OI-MPtot, OSI-ΔPinsp, OSI-MPdyn, and OSI-MPtot. We compared these in surviving and non-surviving patients over the first 7 intensive care unit (ICU) days using Mann–Whitney U test. Logistic regression receiver operating characteristic (ROC) analysis assessed AUC and CI values for ICU mortality on day three. We determined cut-off values using Youden's method and conducted multivariate Cox regression on parameter limits. Results: All indices showed significant differences between surviving and non-surviving patients on the third day of ICU care. The AUC values of OI-ΔPinsp were significantly higher than those of P/F and OI-Pmean ( P values .0002 and <.0001, respectively). Similarly, AUC and CI values of OSI-ΔPinsp and OSI-MPdyn were significantly higher than those of SpO2/FiO2 and OSI-Pmean values (OSI-ΔPinsp: P < .0001, OSI-MPdyn: P values .047 and .028, respectively). OI-ΔPinsp, OSI-ΔPinsp, OI-MPdyn, OSI-MPdyn, OI-MPtot, and OSI-MPtot had AUC values of 0.72, 0.71, 0.69, 0.68, 0.66, and 0.64, respectively, with cut-off values associated with hazard ratios and P values of 7.06 (HR = 1.84, P = .002), 8.04 (HR = 2.00, P ≤ .0001), 7.12 (HR = 1.68, P = .001), 5.76 (HR = 1.70, P ≤ .0001), 10.43 (HR = 1.52, P = .006), and 10.68 (HR = 1.66, P = .001), respectively. Conclusions: Critical values of all indices were associated to higher ICU mortality rates and extended mechanical ventilation durations. The OI-ΔPinsp, OSI-ΔPinsp, and OSI-MPdyn indices displayed the strongest predictive capabilities for ICU mortality. These novel indices offer valuable insights for intensivists in the clinical management and decision-making process for ARDS patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power

Aşar,

Rahim,

Rahimi

et al. 2024

J Intensive Care Med

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“…Demographic and clinical characteristics were recorded for each patient, as well as laboratory variables and drug therapies at the time of admission and during the hospital stay. Recorded variables included the SO 2 /FiO 2 ratio, a non-invasive parameter to estimate the severity of respiratory failure in COVID-19-associated ARDS [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Real-world use of remdesivir for the treatment of patients admitted to Italian hospitals with COVID-19: the nationwide retrospective FADOI-RECOVER study

Pieralli,

Pomero,

Dentali

et al. 2023

BMC Infect Dis

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Background Remdesivir is widely used for treatment of SARS-CoV-2 pneumonia. The aim of this study was to evaluate the characteristics of patients with moderate-to-severe COVID-19 treated with remdesivir, and their outcomes during hospitalization. Methods This retrospective observational multicenter study included consecutive patients, hospitalized for moderate-to-severe COVID-19 (September 2020—September 2021), who were treated with remdesivir. Results One thousand four patients were enrolled, all with onset of symptoms occurring less than 10 days before starting remdesivir; 17% of patients had 4 or more concomitant diseases. Remdesivir was well tolerated, adverse drug reactions (ADRs) being reported in 2.3% of patients. In-hospital death occurred in 80 patients (8.0%). The median timing of the first remdesivir dose was 5 days after symptom onset. The following endpoints did not differ according to the time span from the onset of symptoms to the first dose: length of hospitalization, in-hospital death, composite outcome (in-hospital death and/or endotracheal intubation). Advanced age, number of comorbidities ≥ 4, and severity of respiratory failure at admission were associated with poor in-hospital outcomes. Conclusion In a real-world setting, remdesivir proved to be a safe and well-tolerated treatment for moderate-to-severe COVID-19. In patients receiving remdesivir less than 3 or 5 days from the onset of SARS-CoV-2 symptoms, mortality and the need for mechanical ventilation did not differ from the rest of the sample.

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“…We have read with great interest the article recently published by Zaccagnini et al [1] , entitled "Correlation of non-invasive oxygenation parameters with PaO 2 /FiO 2 ratio in patients with COVID-19 associated ARDS", where they conclude that the SpO 2 /FiO 2 (S/F) ratio is a reliable, non-invasive and easy to track parameter, to monitor patients with coronavirus disease 2019 (COVID-19) with moderate and severe acute respiratory distress syndrome (ARDS), potentially useful to reduce the need to place arterial catheters and the possible consequent thrombotic complications related to COVID–19, so we consider it important to add some comments on this topic.…”

mentioning

confidence: 97%

Usefulness of non-invasive methods for the monitoring of oxygenation parameters in patients with COVID-19 associated acute respiratory distress syndrome (ARDS)

Pinzón

Gómez

Garnica

et al. 2022

European Journal of Internal Medicine

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Correlation of non-invasive oxygenation parameters with paO2/FiO2 ratio in patients with COVID-19 associated ARDS

Cited by 9 publications

References 10 publications

Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power

Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power

Real-world use of remdesivir for the treatment of patients admitted to Italian hospitals with COVID-19: the nationwide retrospective FADOI-RECOVER study

Usefulness of non-invasive methods for the monitoring of oxygenation parameters in patients with COVID-19 associated acute respiratory distress syndrome (ARDS)

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