Correlation of nuclear factor kappa B (NFKB) with sperm quality and clinical diagnoses in infertile men

Ranganathan, Pavithra; Kattal, Namita; Moustafa, Mohamed; Sharma, Rakesh; Thomas, Anthony J.; Agarwal, Ashok

doi:10.1016/s0015-0282(02)03631-2

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SNP rs28362491 in promoter sites of NFKB1 has been reported to have a positive association with both moderate and severe endometriosis caused infertility, and idiopathic female infertility ( 7 ). Ranganathan and coworkers showed that decrease of NFKB1 expression leads to poor sperm production ( 23 ). However, in the literature, there are no studies that illuminate the relationship between oligospermic male infertility and promoter site variations of NFKB1 rs28362491.…”

Section: Discussionmentioning

confidence: 99%

NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study

Tunçdemi̇r¹,

Yenmiş²,

Tombultürk³

et al. 2018

IJRM

View full text Add to dashboard Cite

Background:A notable proportion of idiopathic male infertility cases is accompanied by oligozoospermia; and yet, the molecular mechanisms of fertilization problem underlying this defect are still unclear. Epithelial cadherin has been involved in several calcium-dependent cell-to-cell adhesion events; however, its participation in gamete interaction has also not been fully investigated.Objective:The aim was to investigate the changes in the expression of E-cadherin, based on the frequency of Single nucleotide polymorphisms in Nuclear Factor Kappa-B 1 and pre-mir-146a in oligospermic men.Materials and Methods: In this case-control study, semen and blood samples of 131 oligospermic men as the case group and 239 fertile healthy men as the control group were analyzed. Variants single nucleotide polymorphisms rs28362491 and rs2910164 were performed using polymerase chain reaction-restriction fragment length polymorphism method and E-cadherin expression were determined by immunoprecipitation studies.Results:ins/ins genotype of rs28362491 was determined as a risk factor for idiopathic oligospermia by 1.73 times (p=0.0218), whereas no significant differences were found between the groups concerning pre-mir-146a rs2910164 polymorphism (p=0.2274 in case of GC genotype and p=0.9052 in case of GG genotype). Combined genotype analysis results did not show any notable differences between the multiple comparisons of 28362491-rs2910164 in oligospermic men and control groups. In addition, E-cadherin expression of oligospermic men with ins/ins genotype was significantly lower than patients with del/ins genotype (p=0.0221). E-cadherin expression level was low in oligospermic men with respect to the control group in presence of ins/ins genotype of NFKB1 gene.Conclusion:These results suggest that ins allele prevents binding of surface proteins to spermatozoa, leading to a low affinity of sperm-oocyte interaction in oligospermic men.

show abstract

Section: Discussionmentioning

confidence: 99%

NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study

Tunçdemi̇r¹,

Yenmiş²,

Tombultürk³

et al. 2018

IJRM

View full text Add to dashboard Cite

show abstract

“…The relationship of the variants of the promoter sites of NFKB1 with numerous diseases has been studied widely. Ranganathan et al [50] have associated decreased NFKB1 expression with poor sperm production.…”

Section: Male Infertilitymentioning

confidence: 99%

Functional variations of NFKB1 and NFKB1A in inflammatory disorders and their implication for therapeutic approaches

2020

View full text Add to dashboard Cite

Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) is a sophisticated transcription factor that is particularly important in the inflammatory response, but it regulates more than 400 individual and dependent genes for parts of the apoptotic, angiogenic, and proliferative, differentiative, and cell adhesion pathways. NF-κB function is directly inhibited by the binding of inhibitor of κB (IκB), and the imbalance between NF-κB and IκB has been linked to the development and progression of cancer and a variety of inflammatory disorders. These observations might broaden the horizon of current knowledge, particularly on the pathogenesis of inflammatory diseases considering the roles of NF-κB and IκB. In this context, we focus this narrative review on a comparative discussion of our findings with other literature regarding variations of NFKB1 and NFKB1A and their association with susceptibility to widespread inflammatory disorders (such as atherosclerosis, morbid obesity, Behçet syndrome, Graves disease, Hashimoto disease) and common cancers (such as gliomas).

show abstract

microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials

Rezaei

Zarezadeh

Nikanfar

et al. 2021

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

Correlation of nuclear factor kappa B (NFKB) with sperm quality and clinical diagnoses in infertile men

Cited by 4 publications

References 0 publications

NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study

NFKB1 rs28362491 and pre-miRNA-146a rs2910164 SNPs on E-Cadherin expression in case of idiopathic oligospermia: A case-control study

Functional variations of NFKB1 and NFKB1A in inflammatory disorders and their implication for therapeutic approaches

microRNAs in the pathogenesis of non-obstructive azoospermia: the underlying mechanisms and therapeutic potentials

Contact Info

Product

Resources

About