Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

Abstract

Objective: Adipolin/C1q/TNF-related protein-12 is a family of CTRPs highly expressed in adipose tissue with glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases, such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters. Subject and Methods: A total of 90 patients who were candidates for angiography were included in the study and divided into 3 groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as a control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects. Results: Serum adipolin levels were significantly decreased in patients with AMI compared with the SAP and control groups (p < 0.001 for both). In addition, there was a negative association between serum levels of adipolin and epicardial fat thickness (EFT) and Gensini score in CAD patients. The results of multivariate linear regression analysis revealed that EFT values were independently associated with serum adipolin levels. Conclusion: The current study showed an independent association of adipolin with EFT for the first time in patients with AMI. Decreased adipolin levels in patients with AMI may be involved in the process of atherosclerosis, which requires further study.

Serum Correlation of Nesfatin-1 with Angiographic, Echocardiographic, and Biochemical Findings in Patients with Coronary Artery Disease

“…Although the exact mechanism of EFT in the pathogenesis of patients with CAD is unknown, EFT appears to be involved in the pathogenesis of atherosclerosis with paracrine/ endocrine effects (35). In a previous study, a relationship was shown between EFT and some parameters, such as the Gensini score, LVEF, and WBC (24). In general, the EFT is thought to play a key role in the pathogenesis of the disease in patients with CAD that requires further studies.…”

“…Evidence from animal and human studies has shown that adipose tissue (AP) plays a critical role in some chronic inflammatory diseases, such as cardiovascular disease, rheumatoid arthritis, asthma, and COPD (5,6,24). Moreover, the AP is of utmost importance in the pathogenesis of the disease by activating autocrine/paracrine/endocrine pathways to release a variety of chemical mediators, such as adipolin, visfatin, leptin, fatty acid-binding protein-4, and nesfatin-1 (6,24,26). Nesfatin-1 has been initially recognized as a satiety hormone, as its intracerebroventricular injection in the animal study led to decreased food intake (8).…”

“…The findings of this study were part of the results of a previous study that was conducted from April 2018 to July 2019 in Imam Khomeini Educational and Clinical Hospital, Ardabil, Iran (24). In a crosssectional comparative study, out of 120 patients candidate for angiography, 90 individuals who met the inclusion criteria were included in this study.…”

“…Demographic information, systolic and diastolic blood pressure, associated comorbidities, waist-hip ratio (WHR), cardiovascular risk factors, body mass index (BMI), and medical history of all subjects were collected in this study. Furthermore, hypertension, hyperlipidemia, and type 2 diabetes were defined based on previous studies (24).…”

“…All echocardiographic and angiographic assessments of the study subjects have been fully described previously (24). Briefly, the measured echocardiographic parameters included tricuspid lateral annular systolic velocity, annular plane systolic excursion, mitral valve lateral annular systolic velocity, mitral valve septal annular systolic velocity, left ventricular ejection fraction (LVEF), and EFT.…”