Correlation of Structural and Macroscopic Properties of Starches with Their Tabletability Using the SM2 Approach

Dave, Vivek S; Chanda, Monica; Sayles, Matt; Popielarczyk, Michael; Boyce, Heather; Bompelliwar, Sai Krishna; Bates, Simon; Morris, Ken; Haware, Rahul V.

doi:10.1002/jps.24601

Cited by 6 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…XRPD is a common technique for determining the possible drug-drug and drugexcipients interactions. [28,29] Any physical interactions between the two APIs or API and excipient would result in the change of their characteristic X-ray diffractograms, whether in the form of peak shifting, occurrence of new peaks, or disappearance of existing peaks. Obtained diffractograms show high-intensity sharp peaks characteristic for crystalline APIs (Figure 2).…”

Section: Xrpd Resultsmentioning

confidence: 99%

Thermoanalytical, Spectroscopic and Chromatographic Approach to Physicochemical Compatibility Investigation of 5-Aminosalicylates and Folic Acid

Jeličić¹,

Brusač²,

Kurajica³

et al. 2021

Croat. Chem. Acta

View full text Add to dashboard Cite

Section: Xrpd Resultsmentioning

confidence: 99%

Thermoanalytical, Spectroscopic and Chromatographic Approach to Physicochemical Compatibility Investigation of 5-Aminosalicylates and Folic Acid

Jeličić¹,

Brusač²,

Kurajica³

et al. 2021

Croat. Chem. Acta

View full text Add to dashboard Cite

“…The safety, effectiveness, quality and stability of the drug formulation are the main topics of the new drug development process. The stability of a dosage form with these properties is the result of a thorough study of the physico-chemical properties of the active pharmaceutical ingredient (API) as well as all other ingredients (eg excipients, production aids, packaging) [13]. Drug-excipient compatibility studies maximize the stability of a dosage form.…”

Section: ö Zmentioning

confidence: 99%

Drug-Excipient Compatibility Studies In Binary Mixtures of Tadalafil by Using DSC, TGA and FTIR

Doğantürk

Canbay

2023

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

Objective: During drug preformulation studies, thermal analysis and spectroscopic techniques are used to detect physical or chemical incompatibilities between the active compound and the excipients in the formulation, and to demonstrate the safety and/or efficacy of the final product. It has revolutionized erectile dysfunction with the development of a selective cyclic guanosine monophosphate-specific PDE-5 inhibitors. Tadalafil is one of these inhibitors. Excipients are included in dosage forms to assist in manufacture, absorption or application. Although considered to be pharmacologically inert, the drug active compound may impair effectiveness. Material and Method: DSC, TGA, and FTIR, were used in the work. Ascorbic acid, butylated hydroxyanisole, calcium phosphate dibasic, cellulose, magnesium stearate, mannitol, sodium carboxymethyl cellulose, sucrose, talc, starch, primojel, and citric acid exhibit interaction with Tadalafil. Binary mixtures of drug:excipient have been analyzed. Results: Based on spectroscopic and thermal results; Tadalafil is incompatible with magnesium stearate, mannitol, sucrose, and ascorbic acid. Conclusion: Studies to investigate drug-excipient compatibility are an important step in drug development studies. Thermal and spectroscopic techniques are widely used in such studies.

show abstract

Secondary Processing of Organic Crystals

Wildfong

Haware

et al. 2018

Pharmaceutical Crystals

View full text Add to dashboard Cite

Correlation of Structural and Macroscopic Properties of Starches with Their Tabletability Using the SM2 Approach

Cited by 6 publications

References 33 publications

Thermoanalytical, Spectroscopic and Chromatographic Approach to Physicochemical Compatibility Investigation of 5-Aminosalicylates and Folic Acid

Thermoanalytical, Spectroscopic and Chromatographic Approach to Physicochemical Compatibility Investigation of 5-Aminosalicylates and Folic Acid

Drug-Excipient Compatibility Studies In Binary Mixtures of Tadalafil by Using DSC, TGA and FTIR

Secondary Processing of Organic Crystals

Contact Info

Product

Resources

About