Correlation of the Evolution of Immunity and Inflammation in Vertebrates

Gusev, E. Yu.; Zhuravleva, Yulia; Zotova, Natalia V.

doi:10.1134/s2079086419040029

Cited by 13 publications

(18 citation statements)

References 92 publications

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“…The presence of a microcirculatory network in vertebrates, which determines the possibility of exudative–vascular reactions and directed transendothelial migration of leukocytes, as well as the presence of a system of lymphoid organs, responsible for the development of adaptive immunity [ 64 , 117 ], makes classical inflammation unique to them. As previously stated, the formation of a focus, which limits the affected area, is the fundamental sign of canonical inflammation.…”

Section: Typical Patterns Of Classical Inflammation In Ckd and Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.

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Section: Typical Patterns Of Classical Inflammation In Ckd and Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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“…Inflammation is a key protective mechanism of the host's organism in the case of the parasitic invasion and development of the pathological process (Guseva et al, 2019). Histological analysis of the biological material taken from the infected rats showed pathological changes in organs and tissues with signs of general inflammatory response syndrome.…”

Section: Discussionmentioning

confidence: 99%

The experimental invasion of rats with Eustrongylides excisus (Nematoda, Dioctophymatidae) larvae during the acute course of infection

Honcharov

Kupriianova²,

Soroka

et al. 2022

Regul. Mech. Biosyst.

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Ten laboratory rats were experimentally invaded per os with the Eustrongylides excisus (Jäegerskiold, 1909) nematode larvae (L3–L4) received from Perca fluviatialis (Linnaeus, 1758), caught in the water area of the Dnipro-Buh Estuary, Ukraine. The aim of the experimental study was to measure the pathogenic effect of the given parasite on the mammals’ organisms by means of the histological analysis of the affected organs of the infected rats. The researched animals were divided into two groups. The experiment lasted 15 days; the second group was a control group. The histological analysis showed purulent-serous and purulent-fibrinous peritonitis, acute circulatory disorders in brain tissues (signs of hypoxic-ischemic lesions of the brainstem in the form of neuronal changes) and the heart (partial spasm of arteries and edema of interstitial myocardial tissue); pathological changes in the lungs (acute interstitial purulent pneumonia, acute focal emphysema of the lungs), liver (acute exudative hepatitis), kidneys (signs of shock reaction) and intestines (acute serous-purulent enteritis). Formation of non-specific granulomas was noticed, which contained the fragments of the parasitic larvae. The acute course of the purulent-serous and purulent-fibrinous inflammatory processes in the organs of the invaded rats was noticed; signs of systemic inflammatory response syndrome with pronounced distributive vascular leukocytosis in the studied organs.

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“…An autoimmune response directed against tissues is the sword of Damocles for highly organized species of vertebrates and humans [272]. Organisms with adaptive immunity have multi-stage barriers to the initiation and development of autoimmune response and an autoimmune process (autoimmune inflammation).…”

Section: Possible Causes Of the Autoimmune And Anti-inflammatory Proc...mentioning

confidence: 99%

“…It frequently presents as a MAS-like syndrome, which may be one of the mechanisms for the development of a cytokine storm and systemic inflammation, both of which are life-threatening [4]. It is worth remembering that systemic inflammation is a multifaceted, phase-specific process with hyperergic and depressed manifestations [272,300]. As a result, a cytokine storm, if we define it as critical cytokine levels, should have quantitative characteristics that greatly exceed reference values, such as TNF-α concentration in blood plasma > 200 pg/mL (at N 8 pg/mL) and IL-6 concentration in blood plasma > 1000 pg/mL (at N 5 pg/mL) [301].…”

Section: Possible Causes Of the Autoimmune And Anti-inflammatory Proc...mentioning

confidence: 99%

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

Gusev

Sarapultsev

Соломатина

et al. 2022

IJMS

181

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The review aims to consolidate research findings on the molecular mechanisms and virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and their relevance to four typical stages in the development of acute viral infection. These four stages are invasion; primary blockade of antiviral innate immunity; engagement of the virus’s protection mechanisms against the factors of adaptive immunity; and acute, long-term complications of COVID-19. The invasion stage entails the recognition of the spike protein (S) of SARS-CoV-2 target cell receptors, namely, the main receptor (angiotensin-converting enzyme 2, ACE2), its coreceptors, and potential alternative receptors. The presence of a diverse repertoire of receptors allows SARS-CoV-2 to infect various types of cells, including those not expressing ACE2. During the second stage, the majority of the polyfunctional structural, non-structural, and extra proteins SARS-CoV-2 synthesizes in infected cells are involved in the primary blockage of antiviral innate immunity. A high degree of redundancy and systemic action characterizing these pathogenic factors allows SARS-CoV-2 to overcome antiviral mechanisms at the initial stages of invasion. The third stage includes passive and active protection of the virus from factors of adaptive immunity, overcoming of the barrier function at the focus of inflammation, and generalization of SARS-CoV-2 in the body. The fourth stage is associated with the deployment of variants of acute and long-term complications of COVID-19. SARS-CoV-2’s ability to induce autoimmune and autoinflammatory pathways of tissue invasion and development of both immunosuppressive and hyperergic mechanisms of systemic inflammation is critical at this stage of infection.

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Correlation of the Evolution of Immunity and Inflammation in Vertebrates

Cited by 13 publications

References 92 publications

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

The experimental invasion of rats with Eustrongylides excisus (Nematoda, Dioctophymatidae) larvae during the acute course of infection

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

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