Correlation of the expression levels of BLyS and its receptors mRNA in patients with systemic lupus erythematosus

Ju, Shaoqing; Zhang, Donglei; Wang, Yueguo; Ni, Hongbing; Xiantao, Kong; Zhong, Ruiqin

doi:10.1016/j.clinbiochem.2006.09.010

Cited by 53 publications

(33 citation statements)

References 35 publications

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“…Indeed, two independent groups went on to reach opposing conclusions [32,33]. A more recent study established some correlation [34].…”

Section: Correlation Between Baff and Receptors With Activity And Antmentioning

confidence: 92%

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Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Binard

Saraux

Devauchelle‐Pensec

et al. 2008

Journal of Autoimmunity

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“…Indeed, two independent groups went on to reach opposing conclusions [32,33]. A more recent study established some correlation [34].…”

Section: Correlation Between Baff and Receptors With Activity And Antmentioning

confidence: 92%

“…Expression of mRNA for BR3 and TACI in peripheral blood mononuclear cells from patients with SLE is greater, compared with healthy controls [33]. Despite this, the amount of BAFF that binds to B cells is reduced and the total number of receptors on B cells is similar in SLE patients and healthy donors [34].…”

Section: Baff Overexpressionmentioning

confidence: 98%

Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Binard

Saraux

Devauchelle‐Pensec

et al. 2008

Journal of Autoimmunity

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“…In the present study, it was revealed that the levels of BLyS in the plasma or serum of patients with SLE were significantly higher than those of the control subjects. Additionally, the biological activity of BLyS in circulation was significantly higher compared with the control group, and was closely associated with anti-dsDNA antibody titer, disease activity, ESR, CRP levels, and serum immunoglobulin G (23). A previous study indicated that BLyS may block the expression of apoptosis-related genes in B lymphocytes downstream of signals from the B cell receptor (BCR) (24).…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor-9 is involved in the development of B cell stimulating factor-induced systemic lupus erythematosus

et al. 2017

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Abstract. The objective of the present study was to investigate the role of Toll-like receptor (TLR)-9 in B lymphocyte stimulating factor (BLyS)-induced systemic lupus erythematosus (SLE) in mice. The anti-double stranded (ds)DNA antibody titer, levels of complement proteins (C3 and C4), interleukin (IL)-10 and the disease activity [assessed by the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level] were measured. A total of 21 transgenic female mice (aged 8-10 weeks and weighing 30-40 g) expressing the Epstein-Barr virus membrane antigen, BLLF1, were studied. Mice were randomly divided into the control, the BLyS inhibition and the TLR-9 inhibition groups, with 7 mice in each group. Mice in the blank control group received intraperitoneal injections of normal saline, mice in the BLyS inhibition group received intraperitoneal injections of anti-BR3 monoclonal antibody (5,000 ng/day) and mice in the TLR-9 inhibition group received intraperitoneal injections of anti-human TLR-9 antibody (250 ng/day). The treatment regimens continued for 10 days, followed by the collection of peripheral venous blood. The relative levels of TLR-9 mRNA were measured by reverse transcription-quantitative polymerase chain reaction. Furthermore, the BLyS protein concentration and IL-10 levels were measured by ELISA. TLR-9 mRNA, BLyS, IL-10, anti-dsDNA antibody titer, C3, C4, ESR and CRP levels of the blank control group were significantly higher than those of the other two groups (P<0.05). The differences in comparison of these indexes between the BLyS inhibition and TLR-9 inhibition groups were not statistically significant (P>0.05), with the exception of TLR-9 mRNA and BLyS. In conclusion, the TLR-9 signaling pathway may be important for BLyS-induced SLE, and regulation of the inflammatory immune level.

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“…s-BAFF levels are frequently elevated in SLE patients and associated with disease activity, anti-dsDNA antibodies (Ab) levels and acutephase reactants [13][14][15], while increased BAFF mRNA levels have been found to correlate with disease activity and anti-dsDNA Ab levels in some studies [15,16]. This suggests that BAFF may play a role in the development of LN through its effect on nephritogenic autoantibody production, although the exact mechanism remains unclear [9,17].…”

Section: Introductionmentioning

confidence: 99%

BAFF Expression is Increased in Patients with Lupus Nephritis and Associated with Antinucleosome Antibodies, C1 Inhibitor, Α-1-Acid-Glycoprotein and Endothelial Activation Markers

Eilertsen¹,

Ghelue²,

Nossent³

2012

JDMGP

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Correlation of the expression levels of BLyS and its receptors mRNA in patients with systemic lupus erythematosus

Cited by 53 publications

References 35 publications

Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

Toll-like receptor-9 is involved in the development of B cell stimulating factor-induced systemic lupus erythematosus

BAFF Expression is Increased in Patients with Lupus Nephritis and Associated with Antinucleosome Antibodies, C1 Inhibitor, Α-1-Acid-Glycoprotein and Endothelial Activation Markers

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