Correlation of the relationships of brain—tumor interfaces, magnetic resonance imaging, and angiographic findings to predict cleavage of meningiomas

İldan, Faruk; Tuna, Metin; Göçer, A. İskender; Boyar, Bülent; Bağdatoğlu, Hüseyin; Şen, Orhan; Hacıyakupoğlu, Sebahattin; Burgut, H. Refik

doi:10.3171/jns.1999.91.3.0384

Cited by 84 publications

(57 citation statements)

References 37 publications

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“…There was no correlation between the residual tumor volume and the period to re-treatment (r ＝ 0.041), or between MIB-1 index and the period to re-treatment (r ＝ -0.094). The mean total number of treatments after regrowth of residual tumor was 2.5 (2)(3)(4)(5)(6)(7)(8). No regrowth requiring treatment was observed in any patient throughout the follow-up period in Group A.…”

Section: Resultsmentioning

confidence: 93%

“…All significant factors on univariate analysis suggested tumor invasion and pathological malignancy, as described above, i.e., regions showing the features of malignancy are located in surgically unresectable regions in actual cases, and even though the excised tumor tissue is grade I, the residual tumor may be grade II by histological examination. In addition, a strong correlation between the brain-tumor interface condition and pial-cortical blood supply has been reported, 6) so regrowth is likely to occur in this region because there is sufficient blood supply for the residual tumor.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor location is closely related to resectability including this region. 1,3,6,7,26,28,29) In the absence of clear interface between the tumor and brain, the tumor is resectable if located in a non-eloquent area, but resection is difficult in an eloquent area in consideration of postoperative aggravation of neurological findings, and the residual tumor is inevitably left. Among our 80 cases, 12 cases of unresectable lesion were suspected to have tumor invasion of the brain.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroimaging findings suggesting malignancy are unclear brain-tumor interface, presence of peritumoral edema, and presence of pial-cortical blood supply. 1,3,6,7,26,28,29) Follow-up MR imaging was routinely performed 1 and 3 months postoperatively, then every 6-12 months if the residual tumor size had not changed, and every 3 months if the size had changed. Re-treatment was started if imaging of the residual tumor demonstrated a size that required treatment or when symptoms developed.…”

Section: Methodsmentioning

confidence: 99%

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Radiological Predictive Factors for Regrowth of Residual Benign Meningiomas

Fujimoto¹,

Ishida²,

Uchiyama³

et al. 2011

Neurol. Med. Chir.(Tokyo)

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The pre-and postoperative radiological predictive factors for the regrowth of residual benign meningiomas were investigated in 80 of 327 patients who underwent first surgery for intracranial meningioma, who met the following conditions: residual tumor observed on postoperative imaging, follow up for more than 5 years or until regrowth of the residual tumor, histological diagnosis of World Health Organization grade I, and no additional therapy performed within 1 month after surgery. These 80 patients were divided into those with no regrowth during the follow-up period (Group A, n ＝ 54) and those with regrowth (Group B, n ＝ 26), and the clinical characteristics and pre-and postoperative imaging findings were compared. Univariate analysis of factors influencing regrowth showed 6 factors were significant: tumor size AE4 cm (p ＝ 0.043), tumor volume AE30 cm 3 (p ＝ 0.026), presence of edema (p ＝ 0.036), unclear brain-tumor interface (p º 0.001), presence of a pial-cortical blood supply (p ＝ 0.031), and residual tumor volume AE3.0 cm 3 (p º 0.001). Multivariate analysis showed only residual tumor volume AE3.0 cm 3 was significant (p ＝ 0.001). Generally, the significant imaging findings on univariate analysis suggest malignant meningioma. Similar findings may be observed even in grade I cases, and residual tumors may regrow in such cases. The possibility is particularly high if the residual tumor volume exceeds 3.0 cm 3 , so early radiotherapy should be performed to prevent regrowth.

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Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Radiological Predictive Factors for Regrowth of Residual Benign Meningiomas

Fujimoto¹,

Ishida²,

Uchiyama³

et al. 2011

Neurol. Med. Chir.(Tokyo)

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“…[23][24][25] Tumor infiltration into adjacent brain parenchyma and a pial-cortical blood supply are considered critical factors for the development of peritumoral brain edema in meningioma. 26,27 Our study showed the correlation of a lower grade of "rim-NE" on 3D FLAIR with peritumoral brain edema, possibly indicating tumor infiltration into the surrounding brain tissue at the tumor-brain interface. In addition, a higher grade of "rim-CE," possibly suggesting pial-cortical blood supply, was correlated with a higher grade of peritumoral brain edema with marginal significance.…”

Section: -12mentioning

confidence: 95%

The Rim Pattern of Meningioma on 3D FLAIR Imaging: Correlation with Tumor-brain Adhesion and Histological Grading

et al. 2014

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Purpose: We evaluated the rim patterns of intracranial meningiomas on nonenhanced (NE) and contrast-enhanced (CE) 3-dimensional fluid-attenuated inversion recovery (3D FLAIR) imaging on 3-tesla magnetic resonance (MR) imaging to clarify the associated imaging and pathological findings and the value of the rims in predicting tumor cleavability.Methods: Thirty-two patients with meningioma underwent tumor excision. We classified the rim patterns on 3D FLAIR, subdivided into "rim-NE," a rim with relatively low signal intensity on NE 3D FLAIR and "rim-CE," a rim with relatively high signal intensity on CE 3D FLAIR, into 4 grades by their extent from 0 (no rim visible) to 3 (rim visible over most of the tumor-brain interface) and correlated them with tumor size, grade of peritumoral brain edema, presence/absence of pial supply, grade of tumor-brain adhesion, and histological findings.Results: On NE 3D FLAIR, "rim-NE" was graded 0 in 5 patients, one in 5, 2 in 6, and 3 in 16. On CE 3D FLAIR, "rim-CE" was graded 0 in one patient, one in 13, 2 in 4, and 3 in 14. The grade of "rim-NE" correlated negatively with the grade of brain edema (P = 0.023) and positively with surgical tumor-brain cleavability (P < 0.001). It also correlated with the amount of connective tissue at the tumor-brain interface histologically (P = 0.041). Furthermore, a lower grade of "rim-NE" was more often seen in atypical than benign meningioma (P = 0.003). Although "rim-CE" was more prominent in tumors with pial supply on digital subtraction angiography (DSA) (P = 0.002), it was not useful in predicting tumor-brain adhesion or histological tumor grading.Conclusion: The rim pattern of meningioma on NE 3D FLAIR can predict surgical cleavability and histological tumor grading. A higher grade of rim pattern on CE 3D FLAIR suggests prominent pial supply to the tumor but has no added value in predicting tumor-brain adhesion and histological tumor grading.

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Application of oncogenetic trees mixtures as a biostatistical model of the clonal cytogenetic evolution of meningiomas

Ketter

Urbschat

Henn

et al. 2007

Intl Journal of Cancer

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Meningiomas are mostly benign tumors that originate from the coverings of brain and spinal cord. Typically, they reveal a normal karyotype or monosomy for chromosome 22. Rare clinical progression of meningiomas is associated with a nonrandom pattern of secondary losses of other autosomes. Deletion of the short arm of one chromosome 1 appears to be a decisive step for anaplastic growth in meningiomas. We calculated an oncogenetic tree model that estimates the most likely cytogenetic pathways of 661 meningioma patients in terms of accumulation of somatic chromosome changes in tumor cells. The genetic progression score (GPS) estimates the genetic status of a tumor as progression in the corresponding tumor cells along this model. Large GPS values are highly correlated with early recurrence of meningiomas [p < 10 24 ]. This correlation holds even if patients are stratified by WHO grade. We show that tumor location also has an impact on genetic progression. Clinical relevance of the GPS is thus demonstrated with respect to origin, WHO grade and recurrence of the tumor. As a quantitative measure the GPS allows a more precise assessment of the prognosis of meningiomas than categorical cytogenetic markers based on single chromosomal aberrations. ' 2007 Wiley-Liss, Inc.

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Correlation of the relationships of brain—tumor interfaces, magnetic resonance imaging, and angiographic findings to predict cleavage of meningiomas

Cited by 84 publications

References 37 publications

Radiological Predictive Factors for Regrowth of Residual Benign Meningiomas

Radiological Predictive Factors for Regrowth of Residual Benign Meningiomas

The Rim Pattern of Meningioma on 3D FLAIR Imaging: Correlation with Tumor-brain Adhesion and Histological Grading

Application of oncogenetic trees mixtures as a biostatistical model of the clonal cytogenetic evolution of meningiomas

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