Correlation of tuned aperture computed tomography with conventional computed tomography for evaluation of osseous healing in calvarial defects

Nair, Madhu K.; Nair, Unnikrishnan; Seyedain, Ali; Gaßner, Robert; Piesco, Nicholas P.; Mooney, Mark P.; Ganta, Sudhakar; Agarwal, Sudha

doi:10.1016/j.tripleo.2006.02.006

Cited by 9 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45 Rat cranial defects were regenerated by implanting macroporous 3D constructs based on calcium phosphate and gelatin seeded with human umbilical cord MSCs and bone marrow MSCs; both types of implants generated new bone-57% and 88% for the animals with umbilical cord MSCs and bone marrow MSCs, respectively, at 24 weeks of implantation. 5 Pati et al 46 prepared 3D constructs based on composite material of polycaprolactone (PCL), poly(lacticco-glycolic) acid (PLGA), and b-tricalcium phosphate (b-TCP) by 3D printing. The constructs seeded with differentiated cells and cell-free constructs (control) were implanted in the 8-mm defects of rat skullcaps.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The materials commonly used to repair defects of the skullcap and skull base are titanium, porous ceramics (hydroxyapatites, orthophosphates, tricalcium phosphates, bioglass, natural corals, and so forth), and polymers. 5,6 A promising approach to designing bone implants is the use of the methods of tissue engineering. 7,8 A number of studies reported the effective use of MSCs to repair skull defects in animals 9,10 ; they were also successfully used in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Porous 3D implants of degradable poly‐3‐hydroxybutyrate used to enhance regeneration of rat cranial defect

Shumilova

Мылтыгашев

Кириченко

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

The study describes preparation and testing of porous 3D implants of natural degradable polymer of 3-hydroxybutyric acid P(3HB) for regeneration of bone tissue defects. The ability of the P(3HB) implants to favor attachment and facilitate proliferation and directed differentiation of mesenchymal stem cells (MSCs) was studied in the culture of MSCs isolated from bone marrow and adipose tissue. Tissue-engineered hybrid systems (grafts) constructed using P(3HB) and P(3HB) in combination with osteoblasts were used in experiments on laboratory animals (n = 48) with bone defect model. The defect model (5 mm in diameter) was created in the rat parietal bone, and filling of the defect by the new bone tissue was monitored in the groups of animals with P(3HB) implants, with commercial material, and without implants (negative control). Computed tomography (CT) and histologic examination showed that after 120 days, in the group with the osteoblast-seeded P(3HB) implants, the defect was completely closed; in the group with the cell-free P(3HB) implants, the remaining defect was no more than 10% of the initial one (0.5 mm); in both the negative and positive controls, the size of the defect was about 1.0-1.2 mm. These results suggest that P(3HB) has good potential as osteoplastic material for reconstructive osteogenesis. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 566-577, 2017.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porous 3D implants of degradable poly‐3‐hydroxybutyrate used to enhance regeneration of rat cranial defect

Shumilova

Мылтыгашев

Кириченко

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Iteratively restored TACT showed the best correlation between radiographic findings and biopsy histology (46). The diagnostic performance of TACT has been described as comparable to CT (32).…”

Section: Tuned Aperture Computed Tomography (Tact)mentioning

confidence: 91%

“…Unlike other 3D images, the raw images used are not required to have a rigid, identical orientation. TACT was able to accurately detect osseous healing in surgical defects .…”

Section: Imaging Techniques To Detect Periapical Changesmentioning

confidence: 99%

Cone beam computed tomography and other imaging techniques in the determination of periapical healing

Peters¹,

Peters²

2012

Endodontic Topics

View full text Add to dashboard Cite

To be able to determine if endodontic treatment of apical pathosis is successful or not, healing of lesions is followed up by radiographic imaging. This can be done by observing changes in apical radiolucencies. Recently, cone beam computed tomography (CBCT) has been introduced as a method of gaining an unabridged view of dental anatomy, thus eliminating some of the most prevalent problems, such as superimposition and distortion. CBCT reduces false diagnosis and is rapidly replacing other radiographic techniques in diagnosis, quality control of treatment methods and techniques, and outcome assessment. Healing assessment using conventional and newer three‐dimensional imaging includes, but is not limited to, periapical osseous lesions, conditions of the maxillary sinus, status after endodontic surgery, hard tissue deposition in regeneration procedures, and horizontal root fractures. Due to a low predictive value of two‐dimensional periapical radiographs to distinguish between periapical disease and health, future assessment of endodontic treatment efficacy may include 3D imaging from small field‐of‐view CBCT units.

show abstract

Characterization and preliminary imaging evaluation of a clinical prototype stationary intraoral tomosynthesis system

et al. 2018

View full text Add to dashboard Cite

Purpose: Technological advancements in dental radiography have improved oral care on many fronts, yet diagnostic efficacy for some of the most common oral conditions, such as caries, dental cracks and fractures, and periodontal disease, remains relatively low. Driven by the clinical need for a better diagnostic yield for these and other dental conditions, we initiated the development of a stationary intraoral tomosynthesis (s-IOT) imaging system using carbon nanotube (CNT) x-ray source array technology. Here, we report the system characterization and preliminary imaging evaluation of a clinical prototype s-IOT system approved for human use. Methods: The clinical prototype s-IOT system is comprised of a multi-beam CNT x-ray source array, high voltage generator, control electronics, collimator cone, and dynamic digital intraoral detector. During a tomosynthesis scan, each x-ray source is operated sequentially at fixed, nominal tube current of 7mA and user-specified pulse width. Images are acquired by a digital intraoral detector and the reconstruction algorithm generates slice information in real time for operator review. In this study, the s-IOT system was characterized for tube output, dosimetry, and spatial resolution. Manufacturer specifications were validated, such as tube current, kVp, and pulse width. Tube current was measured with an oscilloscope on the analog output of the anode power supply. Pulse width, kVp, and peak skin dose were measured with a dosimeter with ion chamber and high voltage accessory. In-plane spatial resolution was evaluated via measurement of MTF and imaging of a line pair phantom. Spatial resolution in the depth direction was evaluated via artifact spread measurement. The size of the collimated radiation field was evaluated for compliance with FDA regulations. A dental phantom and human specimens of varying pathologies were imaged on a clinical 2D intraoral imaging system as well as s-IOT for comparison and to explore potential clinical applications. Results: The measured tube current, kVp, and pulse width values were within 3% of the set values. A cumulative peak skin dose of 1.12mGy was measured for one complete tomosynthesis scan using a 50ms pulse per projection view. Projection images and reconstruction slices revealed MTF values ranging from 8.1 to 9.3 cycles/mm. Line pair imaging verified this result. The radiation field was found to meet the FDA requirements for intraoral imaging devices. Tomosynthesis reconstruction slice images of the dental phantom and human specimens provided depth resolution, allowing visibility of anatomical features that cannot be seen in the 2D intraoral images. Conclusions: The clinical prototype s-IOT device was evaluated and found to meet all manufacturer specifications. Though the system capability is higher, initial investigations are targeting a low-dose range comparable to a single 2D radiograph. Preliminary studies indicated that s-IOT provides increased image quality and feature conspicuity at a dose comparable to a single 2D intraoral ...

show abstract

Correlation of tuned aperture computed tomography with conventional computed tomography for evaluation of osseous healing in calvarial defects

Abstract: Potential for TACT to accurately detect osseous healing in surgical defects was demonstrated. High resolution of TACT combined with generation of information in 3D yields comparable performance to CT.

Cited by 9 publications

References 21 publications

Porous 3D implants of degradable poly‐3‐hydroxybutyrate used to enhance regeneration of rat cranial defect

Porous 3D implants of degradable poly‐3‐hydroxybutyrate used to enhance regeneration of rat cranial defect

Cone beam computed tomography and other imaging techniques in the determination of periapical healing

Characterization and preliminary imaging evaluation of a clinical prototype stationary intraoral tomosynthesis system

Contact Info

Product

Resources

About