Correlation of Two Capsule Endoscopy Scoring Systems with Fecal Calprotectin: Does It Really Matter?

Association Between Fecal Calprotectin Levels and Small-bowel Inflammation Score in Capsule Endoscopy: A Multicenter Retrospective Study

“…The overall correlation between FC and LS is moderate at best [18]. This is certainly consistent with the high-negative predictive value (NPV) of FC [9]. Nonetheless, in individuals with higher FC levels, LS does not correlate well, and this can have impact on both patient selection for CE as well as with final outcomes.…”

“…In this single-center study, FC [ 100 lg/g is good predictor of positive smallbowel CE findings, while FC [ 200 lg/g was associated with higher CE diagnostic yield (65 %) and confirmed small-bowel inflammation in 50 % of cases. Hence, it is reasonable to consider that strong correlation should exist between FC levels and LS [7][8][9]. However, in a separate cohort of patients with suspected, isolated small-bowel disease, LS showed strong correlation with FC at levels \100 lg/g [8].…”

“…Both scores are based on parameters and descriptors of inflammatory change and have been externally validated in several reports [5][6][7][8]. However, they are of limited discriminatory ability, and it is still unclear how accurately they measure the degree of mucosal inflammation [6,9].…”

“…At a cutoff level of 100 lg/g, FC can distinguish inflammatory bowel disease (IBD) from non-inflammatory conditions [16]. Therefore, many experts consider FC a reliable and highly specific biomarker of inflammation [9,11]. There are conflicting reports suggesting that the correlation between FC and mucosal inflammation may be weaker in small-bowel inflammation in comparison with the colon.…”

Correlation of the endoscopic findings for small and large bowels in pediatric patients with established Crohn’s disease

“…(9,18) However, the validity of this approach is not known, and the appropriate biomarkers of SB lesion activity in established CD have not been determined to date. (19)(20)(21)(22)(23)(24)(25) We consider that established ileocolonic CD may be detected by ICS and, if the colonic endoscopic findings correlate with small bowel endoscopic findings, small intestinal endoscopic findings may be predicted. However, there is no previous study that reported a correlation between the endoscopic findings of the small bowel and colon in patients with established ileocolonic CD.…”