Correlational analysis between neutrophil granulocyte levels and osteonecrosis of the femoral head

Abstract

Background The correlation between peripheral blood neutrophil level and osteonecrosis of the femoral head (ONFH) has not been extensively studied. Thus, we aimed to investigate the correlation between neutrophil level in the peripheral blood (neutrophil granulocyte) and ONFH. Methods A total of 984 cases of ONFH and femoral neck fractures (non-ONFH) diagnosed at the Department of Orthopedics at our institution between January 1, 2011 and December 31, 2016 were retrospectively reviewed. The ONFH and non-ONFH groups comprised 488 and 496 cases, respectively. Basic information and peripheral blood cell levels of the two groups were compared. Results The patients’ mean age was 59.89 ± 17.06 years (range: 38–82 years). There were 457 male and 527 female patients, with a male-to-female ratio of 1:1.15. We found that neutrophil granulocyte levels and percentage of neutrophil granulocytes were significantly different between the ONFH and non-ONFH groups. Multimodal regression analysis showed that the percentage of neutrophil granulocytes was an independent protective factor against ONFH. Conclusions The factors influencing ONFH are neutrophil granulocyte levels and percentage of neutrophil granulocytes. Percentage of neutrophil granulocytes has a significant correlation with aseptic femoral head necrosis, providing a new perspective and direction for further study of femoral head necrosis.

Identification of key biomarkers in steroid-induced osteonecrosis of the femoral head and their correlation with immune infiltration by bioinformatics analysis

“…Moreover, the results of GSEA showed that immunoregulatory interactions between a lymphoid and a non-lymphoid cell and neutrophil-degranulation pathways were significantly enriched. Jiang et al [ 24 ] demonstrated a significant correlation between the percentage of neutrophils in peripheral blood and ONFH, which was consistent with our results and provided a new direction for further study of ONFH. WGCNA [ 18 ] can find the gene module associated with disease traits from the expression profile data and explore the crucial genes in the module.…”

ARG2, MAP4K5 and TSTA3 as Diagnostic Markers of Steroid-Induced Osteonecrosis of the Femoral Head and Their Correlation With Immune Infiltration

“…Neutrophils derived from bone marrow and acting as the vital components of the body’s natural immunity were suggested to have an important functional role in the body’s defense against invasive factors ( Jablonska et al, 2017 ). Jiang et al (2019) reported that the higher the percentage of neutrophil cells, the more likely patients were to get femoral head necrosis. The findings of existing studies are consistent with those drawn in this study using different methods.…”

“…According to the results of this study, an improved infiltration of neutrophils, and an inhibited activated dendritic cell infiltration and memory B cells might be related to SONFH occurrence and development. It has been shown that the percentage of neutrophils had a significant association with a greater femoral head necrosis incidence ( Jiang et al, 2019 ). Poubelle et al (2007) found that neutrophils participated in bone remodeling processes and local immune responses.…”

“…Chronic inflammatory reactions occurred in and around the necrotic area of the femoral head, and the changes of T-lymphocyte subsets may affect various inflammatory reactions ( Tao et al, 2017 ). The neutrophil percentages and mononuclear macrophage content led to a higher incidence of femoral head necrosis ( Jiang et al, 2019 ). Additionally, from the perspective of the immune system, the evaluation of the degree of infiltration of immune cells and the determination of the differences in the components of infiltration-related immune cells are of high significance for illustrating the molecular pathological mechanism of SONFH and developing novel immunotherapeutic targets.…”

Development and validation of a predictive nomogram for postoperative osteonecrosis of the femoral head with cannulated screws fixation

“…Baseline clinical data were derived from medical and follow-up records (16) and included age (17), sex, body mass index (BMI), injury site, tobacco use, alcohol use (18), cause of injury, preoperative blood tests (19)(20)(21), classification of Submitted Jun 21, 2020. Accepted for publication Nov 27, 2020. doi: 10.21037/atm- View this article at: http://dx.doi.org/10.21037/atm-20-4866 risk of anesthesia according to the American Association of Anesthesiologists (ASA) classification, Charlson's weighted index of comorbidities (WIC), injury severity score (ISS) score, cerebrovascular disease, interval to surgery, preoperative Garden classification, Pauwels angle (22), postoperative Garden index, postoperative interval to partial weight-bearing, postoperative interval to full weightbearing, and six-month postoperative Harris hip score.…”