Correlations between endogen amylin hormone and some hormonal, biochemical and bone parameters in pullets

Abstract

The objective of this study was to assess the correlations of amylin (a pancreatic polypeptide hormone) with some hormonal, biochemical and bone parameters in pullets. Forty 18-week-old pullets were used. Plasma amylin, CT (calcitonin), 1,25 (OH)2 vitamin D (1,25 dihydroxycholecalciferol ), serum osteocalcin, glucose, ALP (alkaline phosphatase), cholesterol, and triglycerides, as well as weight, length and total volume of tibiotarsi were measured. Plasma amylin concentration was negatively correlated with serum cholesterol (p<0.05) and triglycerides (p<0.05) concentrations. Plasma amylin concentration was significantly and positively correlated with plasma calcitonin concentrations (p<0.001). Serum ALP and plasma amylin concentrations were positively correlated (p<0.01). There were no correlations between amylin hormone and other parameters. Based on these results, it is possible to conclude that endogen amylin may effect cholesterol, triglycerides, calcitonin, and ALP levels in pullets without changing some other hormonal, biochemical and bone parameters related to calcium and lipid metabolism.

Effects of amylin on egg quality traits of hens during the early laying period

“…With regard to the external quality of the fresh eggs, the present study showed that amylin injection increased eggshell thickness (P<0.05), and this finding is in agreement with our previous study (Guzel et al, 2009). Even though numerous studies have described a calciotropic (calcium-regulating) effect of amylinomimetic agents including human amylin (Wu et al, 2018) and rat amylin (Davey et al, 2006), information about the effects of amylin in hens is limited with very little literature (Guzel et al, 2009;Guzel and Gunes, 2014). Laying hens lose their structural bone in the late laying period, leading to cortical thining and osteoporosis, causing welfare problems and economic loses (Bain et al, 2016).…”

“…In agreement with this, our previous work have reported that amylin injection in laying hens leads to an increase in bone Ca level, cortical width, and eggshell thickness (Guzel et al, 2009). In our other study, we showed that endogenous amylin appears to interact with calcitonin hormone levels in pullets (Guzel and Gunes, 2014). However, it is not exactly known whether amylin also influences external and internal egg quality traits, and this is addressed in the present study.…”