Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women

Binh, Tran Quang; Nakahori, Yutaka; Hiền, Vũ Thị; Khan, Nguyen Cong; Lâm, Nguyễn Thị; Bạch, Lê Thị; Yamamoto, Shigeru

doi:10.1007/s12041-011-0028-3

Cited by 31 publications

(23 citation statements)

References 36 publications

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“…However, there are many SNP in the intron region of VDR with unknown biological functions. The rs3782905 SNP (between exons 2 and 3 with unknown function) in females aged 35-80 years (n 1773) (39) and ApaI SNP in postmenopausal women (n 140) (40) are associated with obesity, whereby BMI was not defined as clearly as the two groups in our study. In our cross-sectional survey involving 181 adult males, the significance (P = 0·043) of rs3782905 was demonstrated, while ApaI had only difference tendency (P = 0·090) in those aged 35-<50 years.…”

Section: Discussioncontrasting

confidence: 59%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

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Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Design: An intervention trial. Setting: Shenzhen City, Guangdong Province, China. Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.Results: For the survey, there was no significant difference (P > 0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P = 0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P < 0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men. Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. KeywordsVitamin D Obesity Chinese male Parathyroid hormone Insulin resistanceIn China, approximately 12 % of adult males are considered to be obese (1,2) . Since vitamin D nutritional status may be important in regulating obesity (3)(4)(5)(6) , interest was aroused to study Chinese obese males in this regard. Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .In addition, 25(OH)D ≤25 nmol/l (10 ng/ml) is considered to be 'severe vitamin D deficiency', 75-250 nmol/l (30-100 ng/ml) a 'sufficient or optimal' level and 50-75 nmol/l (21-29 ng/ml) an 'insufficient' level (12,13,18) , although these reference ranges are not defined by the Inst...

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Section: Discussioncontrasting

confidence: 59%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

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“…In conflict with the current findings for %BF with Bsm1, a study in Vietnam using the same SNP did not detect a significant relation between %BF and VDR polymorphism [26]. This contradiction could be due to the difference in the population age, stratification and the ethnic background.…”

Section: Discussioncontrasting

confidence: 99%

“…All anthropometric measurements were evaluated in the Nutrition DepartmentQatar University by trained instructors. BMI categorized into the following categories: underweight (<18.5), normal weight (18.5-24.9), overweight (25)(26)(27)(28)(29)(30), and obese (>30) [19], % body fat for females >30% is used as a cut-off point to define obesity [20] and if waist circumference (WC) >88cm is used to define central obesity [21]. The homeostatic model assessment (HOMA) is used to quantify insulin resistance and beta-cell function, whereas HOMA-IR=[Glucose in mmol/l] * [Insulin in mU/L]/22.5 [22].…”

Section: Adiposity Phenotype Measurementsmentioning

confidence: 99%

Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

Sharif¹,

Swaidan²,

Shurbaji³

et al. 2016

EMIJ

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Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas obesity prevalence is increasing dramatically, only a few studies were addressed this relation with obesity based only on body mass index. This study aimed to find the association between three different VDR polymorphisms BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) BsmI, with the adiposity phenotypes (BMI, body fat BF% and waist circumference (WC) as a marker of visceral obesity.

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“…The testing balanced accuracy measures how often individuals are correctly classified with respect to their case/control status, and the cross-validation consistency evaluate the consistency with which individuals are classified. 21 Po0.05 was considered statistically significant in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias

et al. 2012

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We hypothesized that single-nucleotide polymorphisms (SNPs) of genes involved in environmental endocrine disruptors (EEDs) metabolism might influence the risk of male genital malformations. In this study, we explored for association between 384 SNPs in 15 genes (AHR, AHRR, ARNT, ARNT2, NR1I2, RXRA, RXRB, RXRG, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP3A4, CYP17A1 and CYP19A1) and risk of cryptorchidism (CO) and hypospadias (HS) in 334 Japanese (JPN) males (141 controls, 95 CO and 98 HS) and 187 Italian (ITA) males (129 controls and 58 CO). In the JPN study group, five SNPs from ARNT2 (rs2278705 and rs5000770), CYP1A2 (rs2069521), CYP17A1 (rs4919686) and NR1I2 (rs2472680) were significantly associated at both allelic and genotypic levels with risk of at least one genital malformation phenotype. In the ITA study group, two SNPs in AHR (rs3757824) and ARNT2 (rs1020397) were significantly associated with risk of CO. Interaction analysis of the positive SNPs using multifactor dimensionality reduction demonstrated that synergistic interaction between rs2472680, rs4919686 and rs5000770 had 62.81% prediction accuracy for CO (P ¼ 0.011) and that between rs2069521 and rs2278705 had 69.98% prediction accuracy for HS (P ¼ 0.001) in JPN population. In a combined analysis of JPN and ITA population, the most significant multi-locus association was observed between rs5000770 and rs3757824, which had 65.70% prediction accuracy for CO (P ¼ 0.055). Our findings indicate that genetic polymorphisms in genes involved in EED metabolism are associated with risk of CO and HS.

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Correlations between genetic variance and adiposity measures, and gene × gene interactions for obesity in postmenopausal Vietnamese women

Cited by 31 publications

References 36 publications

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes

Association of variants in genes involved in environmental chemical metabolism and risk of cryptorchidism and hypospadias

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