Correlations between histological characterizations and methylation statuses of tumour suppressor genes in Wilms' tumours

Abstract

Wilms' tumour, also known as nephroblastoma, is an embryonal malignant tumour of the kidney. It is the most commonly occurring solid tumour in children, excluding brain tumours. [1][2][3] The aetiology of Wilms' tumour is still poorly understood, although a number of associated genes and loci have been identified. 4,5 The genetic changes in Wilms' tumours are diverse and involve approximately 40 genes. 6 Genes that have been previously implicated include WT1,

Diagnóstico e manejo do Tumor de Wilms na população infantil

“…A etiologia ainda não é totalmente esclarecida, no entanto acredita-se que mutações genéticas estejam interligadas com as alterações no desenvolvimento embriológico normal do trato geniturinário. Dentre os marcadores genéticos correlacionados ao TW estão os genes WT1, CTNNB1, WTX, TP53 e MYNC, sendo os piores prognósticos associados frequentemente ao gene supressor TP53 e aos prejuízos da heterozigosidade nos cromossomos 1p, 1q, 11p15 4,5 .…”