Correlations between lipoprotein(a) gene polymorphisms and calcific aortic valve disease and coronary heart disease in Han Chinese

Abstract

Objective To investigate the relationship between lipoprotein(a) gene ( LPA) polymorphisms and calcific aortic valve disease (CAVD) and coronary heart disease (CHD) in Han Chinese. Methods A total of 148 patients were recruited (n = 71 with CAVD and n = 77 with CHD) based on a diagnosis achieved using color Doppler echocardiography, coronary angiography, or computed tomography angiography. Seventy-one control individuals without CAVD or CHD were also recruited. Biomarkers including levels of lipoprotein(a) [Lp(a)], low-density lipoprotein and high-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were tested. LPA polymorphisms rs10455872, rs6415084, rs3798221, and rs7770628 were analyzed using SNaPshot SNP. Results Lp(a) levels were significantly higher in CAVD and CHD groups compared with controls. There was no significant difference in the allelic frequency distribution of rs3798221, rs7770628, or rs6415084 between CHD, CAVD, and control groups. Linear regression showed that rs3798221, rs7770628, and rs6415084 were associated with increased Lp(a) concentrations. Two CAVD patients among the 219 participants carried AG minor alleles at rs10455872, while the remainder carried AA minor alleles. Conclusion rs3798221, rs6415084, and rs7770628 polymorphisms within LPA are associated with higher Lp(a) plasma levels, which correlate with increased CAVD and CHD risks.

The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population

“…In addition to the classic risk factors such as age, smoking, drinking, hypertension, diabetes, and hypercholesterolemia [ 9 ], a large number of studies have confirmed that genetic factors play an important role in the occurrence and development of CHD [ 10 ]. Besides, many genetic variants such as LPA [ 11 ], CYP24A1 [ 12 ], CYP2C19 [ 13 ], PNPLA3 I148M [ 14 ], and IL-7 / 7R [ 15 ] can significantly affect the susceptibility of CHD.…”

Lipoprotein(a) and Cardiovascular Disease in Chinese Population

“…Compared with other populations, the epidemiology of Lp(a) in the Chinese population shows a unique differentiation. Dong et al 12 found a genetic variation in Lp(a) at single nucleotide polymorphisms (SNPs) rs6415084, rs3798221, and rs7770628, which may cause the differentiation of high Lp(a) plasma levels among the Han Chinese population. A cross-sectional study of 3,462 case and 6,125 control subjects also suggested that the Lp(a) distribution in the Chinese Han population differs from that in Caucasian populations, and high Lp(a) levels can be modified by some risk factors in the Chinese Han population.…”

Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS)

“…However, previous studies report the association of this polymorphism with the LP(a) level [ 28 – 30 ]; unfortunately, the Lp(a) level was not measured in this study.…”