Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice*1

Silkworth, Jay B.; Antrim, LuAnn; Kaminsky, Laurence S.

doi:10.1016/0041-008x(84)90086-3

Cited by 109 publications

(32 citation statements)

References 23 publications

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“…Despite the difference in dosing regimen, the administration of PB produced an induction of PROD activity equivalent to that of mice treated with 358 mg/kg PCB153; however, there was no effect on the PFC response in mice, suggesting a lack of concordance between PROD induction and enhancement of the PFC response. In addition, these results corroborate earlier work by Silkworth et al (1984), who demonstrated that the PFC response of male B6 mice was not affected by a PB dosage of 88.7 mg/kg/day for 2 days.…”

Section: Discussionsupporting

confidence: 82%

“…Certain structurally related HAHs which are approximate isostereomers of TCDD (e.g., coplanar and mono-ortho coplanar PCB congeners), display Ah agonist activity and suppress the PFC response to SRBCs in mice (Silkworth et al, 1984;Davis and Safe, 1990). On the other hand, some complex PCB mixtures such as Aroclor 1242, 1248, 1254, and 1260 (Bannister et al, 1987;Davis and Safe, 1989), PCBs such as 2, 3,3',4,5'-penta-and 2,3,3',4,5,5'-hexachlorobiphenyl (Davis and Safe, 1990), and the 2,3,7,8-tetrachlorodibenzo-/7-furan (TCDF) derivative 6-methyl-l,3,8-trichlorodibenzofuran (Bannister et al, 1989) partially antagonize the immunosuppressive effects of TCDD in mice.…”

mentioning

confidence: 99%

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Opposite Effects of 2,2′,4,4′,5,5′-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antibody Response to Sheep Erythrocytes in Mice

et al. 1997

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Opposite Effects of 2,2′,4,4′,5,5′-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antibody Response to Sheep Erythrocytes in Mice

et al. 1997

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“…(36)(37)(38), and possibly in humans (39). Exposure to PCBs can result in reduced relative spleen (31,32,40) and thymus (40) size, decreased T cell-dependent antibodyforming cell (AFC) formation (31,32), lower T cell-dependent antibo.dy titer (32,36,39), depressed cytotoxic T lymphocyte (CTL) response (40), and reduced delayed-type hypersensitivity (39). Further, PCB exposure can reduce lymphocyte proliferation responses to phytohemagglutinin (33,38) and can alter natural killer (NK) cell activity (33).…”

Section: Resultsmentioning

confidence: 99%

Decreased Lymphocyte Responses in Free-Ranging Bottlenose Dolphins (Tursiops truncatus) Are Associated with Increased Concentrations of PCBs and DDT in Peripheral Blood

Lahvis¹,

Wells²,

Kuehl³

et al. 1995

Environmental Health Perspectives

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Since 1987, large-scale mortalities of dolphins have been reported along the Atlantic coast of North America, in the Gulf of Mexico, and in the Mediterranean Sea. Autopsied bottlenose dolphins, Tursiops truncatus, which were collected from the large-scale mortality along the Atlantic coast in 1987 to 1988, exhibited opportunistic infections indicative of immune dysfunction. Further, these animals had high levels of chlorinated hydrocarbons, such as PCBs and DDT, that can suppress immune functions. The purpose of this study was to determine whether there is a relationship between chemical contaminant exposure and immune response in free-ranging dolphins. In June of 1991, peripheral blood was obtained from members of a bottlenose dolphin population that resides along the west coast of Florida. Peripheral blood lymphocyte responses to Concanavalin A (Con A) and phytohemagglutinin (PHA) were determined in vitro and compared by regression analysis with contaminant concentrations in whole blood from a small subset of these animals (n= 5). These data indicate that a reduced immune response in these bottlenose dolphins was correlated with increasing whole blood concentrations of several contaminants. Specifically, inverse correlations were found between Con A-induced lymphocyte proliferation and tetrachlorinated to octachlorinated biphenyls (r2 values ranged from 0.70 to 0.87). (1995)

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“…B lymphocytes, which mature in the bursa of Fabricius in birds and the bone marrow or Peyer's patches in mammals, produce antibodies that destroy invading microorganisms. High doses of HAHs suppress antibody responses (22,23,28,42,44,45,(48)(49)(50). HAHs reduce concentrations of retinol [vitamin A] and thyroxine (51)(52)(53)(54), which are important for immune function (55)(56)(57).…”

Section: Introductionmentioning

confidence: 99%

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

Grasman¹,

Fox²,

Scanlon³

et al. 1996

Environmental Health Perspectives

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The objectives of this study were to determine whether contaminant-associated immunosuppression occurs in prefledgling herring gulls and Caspian terns from the Great Lakes and to evaluate immunological biomarkers for monitoring health effects in wild birds. During 1992 to 1994, immunological responses and related variables were measured in prefledgling chicks at colonies distributed across a broad gradient of organochlorine contamination (primarily polychlorinated biphenyls), which was measured in eggs. The phytohemagglutinin skin test was used to assess T-lymphocyte function. In both species, there was a strong exposure-response relationship between organochlorines and suppressed T-cell-mediated immunity. Suppression was most severe (30-45%) in colonies in Lake Ontario (1992) and Saginaw Bay (1992)(1993)(1994) for both species and in western Lake Erie (1992) for herring gulls. Both species exhibited biologically significant differences among sites in anti-sheep red blood cells antibody titers, but consistent exposure-response relationships with organochlorines were not observed. In Caspian terns and, to a lesser degree, in herring gulls, there was an exposure-response relationship between organochlorines and reduced plasma retinol (vitamin A). In 1992, altered white blood cell numbers were associated with elevated organochlorine concentrations in Caspian terns but not herring gulls. The immunological and hematological biomarkers used in this study revealed contaminantassociated health effects in wild birds. An epidemiological analysis strongly supported the hypothesis that suppression of T-cell-mediated immunity was associated with high perinatal exposure to persistent organochlorine contaminants.Environ Health Perspect 104(Suppl 4): 829-842 (1996)

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Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice*1

Cited by 109 publications

References 23 publications

Opposite Effects of 2,2′,4,4′,5,5′-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antibody Response to Sheep Erythrocytes in Mice

Opposite Effects of 2,2′,4,4′,5,5′-Hexachlorobiphenyl and 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Antibody Response to Sheep Erythrocytes in Mice

Decreased Lymphocyte Responses in Free-Ranging Bottlenose Dolphins (Tursiops truncatus) Are Associated with Increased Concentrations of PCBs and DDT in Peripheral Blood

Organochlorine-Associated Immunosuppression in Prefledgling Caspian Terns and Herring Gulls from the Great Lakes: An Ecoepidemiological Study

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