Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)

Ahmad, Inass Hassan; Mostafa, Ehab M.; Mohammed, Shymaa; Shipl, Walaa; Soliman, A. A.; Said, Marwa

doi:10.1080/13813455.2020.1808018

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…Interestingly, Vit-D supplementation increases the level of circulating irisin by directly stimulating the intramuscular synthesis of its precursor (fibronectin type III domain-containing protein 5 or FNDC5) [ 234 ], which probably mediates both metabolic and functional parameters [ 235 , 236 ]. There is a direct relationship between serum testosterone concentration and irisin levels in men with metabolic syndrome [ 237 , 238 ]. Other data show that insulin resistance is associated with increased basal but not post-exercise levels of irisin [ 239 , 240 ], indicating that the condition of irisin resistance may play a role in the early stages of T2D.…”

Section: Future Directionsmentioning

confidence: 99%

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco,

Disoteo,

De Tullio

et al. 2023

Nutrients

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Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.

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Section: Future Directionsmentioning

confidence: 99%

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Lisco,

Disoteo,

De Tullio

et al. 2023

Nutrients

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“…Consequently, adults with low SHBG can have elevated bioavailable and free testosterone levels [ 39 ]. Elevated testosterone levels may reduce the incidence rate of MetS [ 40 , 41 ]. A recent study found a positive association between the free estradiol index and the incidence of MetS in males of all ages, as well as in older females [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Association between sex hormone binding globulin and metabolic syndrome in US adults: insights from National Health and Nutrition Examination Survey (NHANES) 2013–2016

Yang,

Wang,

Huang

et al. 2024

Diabetol Metab Syndr

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Background Metabolic syndrome (MetS) presents a notable public health challenge on a global scale, exerting a considerable impact on individuals’ health and quality of life. There is mounting evidence indicating a robust association between MetS and levels of sex hormones. Therefore, the study aims to explore the relationship between sex hormone binding-globulin (SHBG) and MetS, and to provide evidence that could inform the development of effective prevention strategies for MetS. Methods Data for this cross-sectional investigation were collected during the 2013–2016 cycle of the National Health and Nutrition Examination Survey (NHANES), from which 5,499 adults were sampled. The criteria established by the Adult Treatment Program III of the National Cholesterol Education Program were utilized to define MetS. SHBG levels were measured using a standardized technique. Multivariate-adjusted logistic regression, multivariate restricted cubic spline, and threshold effect analyses were utilized to investigate the association between SHBG levels and MetS. Moreover, the stratified analyses and interaction tests of covariables were presented in a forest plot. Finally, sensitivity analysis was utilized to ensure the robustness of the results. Results Overall, 1822 participants had MetS. After adjusting for possible confounders, SHBG levels were associated with MetS (Odds ratio [OR], 0.984; 95% confidence interval [CI], 0.981–0.986; P < 0.01). The multivariate restricted cubic spline analysis demonstrated a non-linear association between SHBG and MetS (P < 0.001). With two piecewise regression models, the adjusted OR of developing MetS was 0.964 (95% CI, 0.959–0.969; P < 0.001) among people with SHBG < 76.653 nmol/L, but there was no correlation between SHBG and MetS in participants with SHBG ≥ 76.653 nmol/L. The stability of the association between SHBG levels and MetS was confirmed using subgroup analysis and sensitivity analyses. Conclusions Our results suggest that reduced SHBG levels are associated with an increased prevalence of MetS in adults, particularly when SHBG levels are below 76.653 nmol/L. More investigation is required to understand comprehend the mechanisms underlying these results and to delve into their clinical implications.

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“…In fact, this question is difficult to discuss, since there are no previous studies assessing this relationship. A recent study on a sample of Egyptian men with MetS proved positive correlation between circulating irisn and serum testosterone 34 . Furthermore, Li et al, 32 found a significant positive correlation between serum irisin concentration and free androgen index (FAI) in women with polycystic ovary syndrome (obese and non‐obese), concluding that high serum irisin could be used as a strong predictor of hyperandrogenism, but the causal link and direction of that link are difficult to infer.…”

Section: Discussionmentioning

confidence: 99%

Circulating and/or cutaneous irisin resistance: A novel link among androgenetic alopecia, comorbid metabolic syndrome and cardiovascular risks

Dawoud

Hefnawy

et al. 2023

J of Cosmetic Dermatology

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Background: Androgenetic alopecia (AGA) is a common cause of hair loss in both genders that may be associated with disturbed systemic metabolism. Irisin is a hormone-like myokine that greatly influences systemic metabolism and is linked to cardiovascular diseases. Aim:To detect irisin role in AGA and its associated metabolic syndrome (MetS) and cardiovascular risk.Patients/Methods: This case-control study included 44 AGA patients of both genders and 22 healthy individuals. Serum irisin level was measured using ELISA and scalp biopsy was taken to detect irisin immunohistochemically. Carotid Doppler ultrasonography was performed to measure carotid intima media thickness (CIMT).Results: Higher serum irisin was significantly detected in AGA patients (p ˂ 0.001), and in males (p = 0.01) particularly severe cases (p ˂ 0.001). It was significantly higher in AGA patients presenting with MetS and those suffering from dyslipidemia (p ˂ 0.001 for both). Multivariate regression analysis proved BMI (p = 0.01) and serum irisin (p = 0.02) as independent predictors of CIMT abnormality among AGA patients.Regarding cutaneous irisin expression, the epidermal H-score was significantly higher in AGA patients with MetS compared to those without (p = 0.04). Epidermal H-score ˃100 was significantly associated with male gender (p = 0.05), severe AGA (p = 0.02), MetS (p = 0.03), dyslipidemia (p = 0.03), and abnormal CIMT (p = 0.03). Conclusion:High serum irisin and upregulated epidermal irisin expression are associated with the incidence of MetS, dyslipidemia, and CIMT abnormality among AGA patients. This may indicate resistance to irisin, which hinders its favorable cardiometabolic actions. Further studies are warranted to investigate the concept of irisin resistance in AGA patients, which was uniquely discussed in the present study.

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Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome; (case-control study)

Cited by 7 publications

References 29 publications

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Association between sex hormone binding globulin and metabolic syndrome in US adults: insights from National Health and Nutrition Examination Survey (NHANES) 2013–2016

Circulating and/or cutaneous irisin resistance: A novel link among androgenetic alopecia, comorbid metabolic syndrome and cardiovascular risks

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