Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐ and post‐treatment

Liang, Jinyan; Nong, Song; Jiang, Liejun; Chi, Xiaowei; Bi, Dewu; Cao, Jun; Mo, Lida; Luo, Xiaolu; Huang, Huayi

doi:10.1002/jcla.23609

Cited by 15 publications

(14 citation statements)

References 42 publications

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“…The strong associations among CD3+, CD3+4+, and CD3+8+ with CRP could represent the basis to plan a prospective study to assess whether these biomarkers can be useful to predict the response to therapy. For interested readers, other results on the same topic are reported elsewhere [4][5][6][7].…”

Section: Resultsmentioning

confidence: 99%

Relationship between lymphocyte subsets values andC‐reactiveprotein inCOVID‐19 patients

Mangano

Oliva

2021

Cytometry Pt A

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We enrolled 33 patients with COVID‐19 (23 men and 10 women; age 59 ± 15; males, n = 23; females, n = 10) admitted to the Department of Infectious Diseases of Grande Ospedale Metropolitano “Bianchi‐Melacrino‐Morelli” of Reggio Calabria, Italy, between March and May 2020. Whole blood samples were collected before the start of therapeutic treatment using all virus spread containment measures. Sample preparation protocols were designed in order to minimize operators direct specimen's manipulation. On univariate analysis, circulating levels of CRP were strongly and inversely related to CD3+ (rho = −0.77, p < 0.001), CD3+4+ (rho = −0.74, p < 0.001), and CD3+8+ (rho = −0.66, p = 0.001) implying that the shared variances between absolute values T cells and CRP ranged from 44 to 59%. Of note, the strength of these associations was higher in patients with relatively lower (below the median value) white blood cells (WBC) as compared to those with WBC above the median value. CRP also correlated with NK bright (rho = −0.56, p = 0.005) but failed to be related with CD19+ (rho = −0.38, p = 0.07), CD4+/CD8+ ratio (rho = 0.03, p = 0.89), CD16+ CD56+ (rho = −0.18, p = 0.43), and NKdim (rho = −0.15, p = 0.49). Lymphocyte subsets alteration monitoring in COVID‐19 positive patients may be a valid aid to control treatment efficacy of therapy and to choose better clinical approach. In particular, the negative correlation between CD3+, CD3+CD4+, CD3+CD8+ T cells values and CRP could be a useful tool to predict patient's response to therapy, particularly in patients with relatively lower WBC.

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Section: Resultsmentioning

confidence: 99%

Relationship between lymphocyte subsets values andC‐reactiveprotein inCOVID‐19 patients

Mangano

Oliva

2021

Cytometry Pt A

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“…Similarly, lymphocyte counts below 5% (375/mm 3 ) were only present in patients with severe diseases. Chen et al showed a tendency for lymphopenia to be more marked and long-lasting in the most severe patients [ 25 , 26 ]…”

Section: Discussionmentioning

confidence: 99%

Lymphopenia and Early Variation of Lymphocytes to Predict In-Hospital Mortality and Severity in ED Patients with SARS-CoV-2 Infection

Simon

Borgne

Lefevbre³

et al. 2022

JCM

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(1) Introduction: Multiple studies have demonstrated that lymphocyte count monitoring is a valuable prognostic tool for clinicians during inflammation. The aim of our study was to determine the prognostic value of delta lymphocyte H24 from admission from the emergency department for mortality and severity of SARS-CoV-2 infection. (2) Methods: We have made a retrospective and multicentric study in six major hospitals of northeastern France. The patients were hospitalized and had a confirmed diagnosis of SARS-CoV-2 infection. (3): Results: A total of 1035 patients were included in this study. Factors associated with infection severity were CRP > 100 mg/L (OR: 2.51, CI 95%: (1.40–3.71), p < 0.001) and lymphopenia < 800/mm3 (OR: 2.15, CI 95%: (1.42–3.27), p < 0.001). In multivariate analysis, delta lymphocytes H24 (i.e., the difference between lymphocytes values at H24 and upon admission to the ED) < 135 was one of the most significant biochemical factors associated with mortality (OR: 2.23, CI 95%: (1.23–4.05), p = 0.009). The most accurate threshold for delta lymphocytes H24 was 75 to predict severity and 135 for mortality. (4) Conclusion: Delta lymphocytes H24 could be a helpful early screening prognostic biomarker to predict severity and mortality associated with COVID-19.

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“…In many studies, NLR, BLR, platelet count and platelet-to-lymphocyte ratio have been used as markers to determine the disease's severity and mortality rate in COVID-19. 5,6,13 MPV has been evaluated in a few studies. 7,14 In a study, it was reported that the high values of MPR score obtained by proportioning MPV to the platelet count predicted the development of severe pneumonia in COVID-19.…”

Section: Discussionmentioning

confidence: 99%

A simple scoring system in COVID-19 patients with neurological manifestations

et al. 2021

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Background: Coronavirus disease 2019 (COVID-19) has affected a rapidly growing patient population worldwide. To effectively manage the disease, physicians need tests or methods that classify patients according to their risks. Our aim is to determine the importance of mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), MPVNLR score (MPV×Neutrophil/lymphocyte) in predicting the clinical course and mortality in hospitalized COVID-19 patients with neurological manifestations. Methods: A total of 300 patients were enrolled in the study. MPV, NLR, MPVNLR score, CRP, D-dimer, IL-6, and procalcitonin tests were obtained for each patient. Results: MPV, NLR, MPVNLR score, IL-6, D-dimer, procalcitonin, and CRP in the non-survivor group were higher than the survivor group (p=0.001, p:0.001, p=0.001, p=0.001, p=0.001, p=0.027, and p=0.001, respectively). MPV, NLR, MPVNLR score, IL-6, D-dimer, procalcitonin and CRP were higher in patients with altered mental status (p=0.001, p=0.001, p=0.001, p=0.014, p=0.002, p=0.026, and p=0.001, respectively). Conclusion: High MPV, NLR, and MPVNLR scores may be simple markers to predict mortality and mental deterioration in COVID-19.

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Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐ and post‐treatment

Cited by 15 publications

References 42 publications

Relationship between lymphocyte subsets values andC‐reactiveprotein inCOVID‐19 patients

Relationship between lymphocyte subsets values andC‐reactiveprotein inCOVID‐19 patients

Lymphopenia and Early Variation of Lymphocytes to Predict In-Hospital Mortality and Severity in ED Patients with SARS-CoV-2 Infection

A simple scoring system in COVID-19 patients with neurological manifestations

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