Corrigendum: Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Ferro, Thiago Azevedo Feitosa; Araújo, Jéssica Mayara Mendes; Pinto, Bruna Lorrana dos Santos; Santos, Jéssica S. dos; Souza, Eliana Barbosa de; Silva, Bruna L. R. da; Colares, Valderlane L. P.; Novais, Tânia Maria Gaspar; Filho, Clóvis Macêdo Bezerra; Struve, Carsten; Calixto, João Β.; Monteiro-Neto, Valério; Silva, Luís C. N. da; Fernandes, Elizabeth S.

doi:10.3389/fmicb.2020.628074

Front. Microbiol.

2021

DOI: 10.3389/fmicb.2020.628074

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Corrigendum: Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Thiago Azevedo Feitosa Ferro

Jéssica Mayara Mendes Araújo

Bruna Lorrana dos Santos Pinto

et al.

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2023

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Cited by 2 publications

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Atividade anti-Staphylococcus aureus e anti- Klebsiella pneumoniae do cinamaldeído e suas interações com ATP sintase e FtsZ através do docking molecular

Andrade de Oliveira,

Da Silva Rodrigues,

Alves de Oliveira Filho

et al. 2023

Rev. Colomb. Cienc. Quím. Farm.

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Introdução: as infecções bacterianas tornaram-se um grande desafio na área da saúdedevido ao surgimento e disseminação de bactérias multirresistentes, o que levou aoaumento do interesse no desenvolvimento de novos agentes antimicrobianos. Objetivo:investigar o potencial antibacteriano do cinamaldeído contra Staphylococcusaureus e Klebsiella pneumoniae bem como, estudar as interações desse fitoquímicocom a ATP sintase e a FtsZ através do docking molecular. Metodologia: nos ensaiosin vitro foram aplicados a técnica da microdiluíção em placas de 96 poços para obtera concentração inibitória e bactericida mínima (CIM e CBM). Para os ensaios insílico, o procedimento adotado foi o da ancoragem molecular com a proteína rígida(ATP sintase e a FtsZ) e o ligante flexível. Resultados: verificou-se uma forte atividadeantibacteriana contra S. aureus e K. pneumoniae do cinamaldeído com CIM= 64 e 32 μg/mL respectivamente e CBM = 128 e 64 μg/mL respectivamente, commelhor espectro de ação contra bactérias Gram negativas. Além disso, o cinamaldeídofoi capaz de ligar-se a ATP sintase e a FtsZ com energias de ΔE = -5.10 kcal/mol e ΔE = -5.20 kcal/mol de modo respectivo. Conclusão: o cinamaldeído apresenta efeito bactericida contra S. aureus e K. pneumoniae e de modo preditivo esseefeito ocorre por causa das interações desse fitoquímico com a ATP sintase e a FtsZ.

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Atividade anti-Staphylococcus aureus e anti- Klebsiella pneumoniae do cinamaldeído e suas interações com ATP sintase e FtsZ através do docking molecular

Andrade de Oliveira,

Da Silva Rodrigues,

Alves de Oliveira Filho

et al. 2023

Rev. Colomb. Cienc. Quím. Farm.

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Efficiency of the fungal filtrate Beauveria bassiana and the alcoholic extract of Artemisia herba-alba against the greater wax worm Galleria mellonella L. (Lepidoptera: Pyralidae) in Babylon Province

Hamad Hamza Al Sultani,

Ghanem Hamza

2023

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A laboratory study was conducted to determine the effect of the filtrate of the fungus Beauveria bassiana and the alcoholic extract of the wormwood plant Artemisia herba-alba on the destruction of the larval stages of the waxworm major; the results of the study showed that the filter of the fungus B. bassiana affected the destruction of the larval stages of the waxworm. The highest mortality rate was 76.7% for the second larval stage after 24 hours of treatment with a 30% concentration, while it reached 86.7% after 168 hours of treatment with the same concentration. The lowest mortality rate was 13.3% for the last larval stage after 24 hours of treatment, with a concentration of 10%. In comparison, the death rate was 30.0% after 168 hours of treatment, with a concentration of 10%. The results also showed that the alcoholic extract of the wormwood plant affected the destruction of the larval stages of the insect. Keywords: Fungal; Alcoholic Extract; Wormwood.

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Corrigendum: Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Cited by 2 publications

References 9 publications

Atividade anti-Staphylococcus aureus e anti- Klebsiella pneumoniae do cinamaldeído e suas interações com ATP sintase e FtsZ através do docking molecular

Atividade anti-Staphylococcus aureus e anti- Klebsiella pneumoniae do cinamaldeído e suas interações com ATP sintase e FtsZ através do docking molecular

Efficiency of the fungal filtrate Beauveria bassiana and the alcoholic extract of Artemisia herba-alba against the greater wax worm Galleria mellonella L. (Lepidoptera: Pyralidae) in Babylon Province

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