Corrigendum: Drosophila as a model to study the mechanism of nociception

He, Jianzheng; Li, Botong; Han, Shuzhen; Zhang, Yuan; Li, Kai; Yi, Simeng; Liu, Yongqi; Xiu, Minghui

doi:10.3389/fphys.2022.956551

Cited by 1 publication

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“…The fruit fly Drosophila has been proved as an excelent in vivo model for dissecting mechanism and drug screening of various disease, such as cancer, intestinal disease and neurodegenerative disease ( Gonzalez, 2013 ; He et al, 2021 ; He et al, 2022 ). Fly midgut is an attractive system to detect the intestinal inflammatory disease, due to its similar anatomical features with mammal intestine and its conserved molecular pathways with mammals ( Medina et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

Li²,

Yang³

et al. 2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal inflammation, which currently lacks safe and effective medicines. Astragalus membranaceus (AM), also named Huangqi, is one of the most commonly used fundamental herbs in China. Here, we aimed to investigate mechanism and bioactive compounds of AM on treating sodium dodecyl sulfate (SDS)- induced colitis in Drosophila flies. Our data showed that AM extract (AME) supplementation had no toxic effect in flies, and protected flies against SDS-induced lifespan shortening, intestinal morphological damage, and colon length shortening. Moreover, AME supplementation remarkably rescued SDS-induced intestinal stem cell (ISC) overproliferation and increased reactive oxygen species (ROS) level in the intestine. Mechanistically, AME remarkably rescued the altered expression levels of genes and proteins in c-Jun N-terminal kinase (JNK) and JAK-STAT signaling pathways induced by SDS in gut. Additionally, formononetin, isoliquiritigenin, isorhamnetin, astragaloside I, astragaloside III, vanillic acid, and caffeic acid in AM had protection against SDS-induced inflammatory damage in flies. Taken together, AME could ameliorate the intestinal inflammation partially by suppressing oxidative stress-associated JNK signaling and JAK-STAT signaling pathways. AME may provide a theoretical basis for natural medicine toward treating intestinal inflammatory disease in human.

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