Osteoarthritis is a common disease of the synovial joints, affecting millions of dogs worldwide and evolving with pain, understanding the mechanisms of pain being the key to success in its prevention and treatment. The aim of the study was to evaluate the effectiveness of drug combinations in treating pain for chronic patients. In this micro-study, 15 dogs that presented symptoms associated with locomotor pain were included, the main objectives being to determine the degree of pain using a specific questionnaire, to evaluate the questionnaire compared to general and paraclinical examination techniques and to demonstrate the effectiveness of drug therapy and relief of symptoms associated with locomotor pain using long-term pharmaceutical supplements. The study revealed that: therapies with nutraceutical supplements, in the case of locomotor pathologies in dogs, have been shown to have fewer adverse or side effects compared to anti-inflammatory therapy. Treatment with chondroitin sulfate and glucosamine revealed the most positive results in the therapy of locomotor pathologies. In addition to establishing the diagnosis through certain imaging methods, such as computed tomography/radiology, the diagnosis of locomotor disorders can also be ensured, with a high margin of accuracy, through acute/chronic pain interpretation methodologies such as specific questionnaires.