Corrigendum to “Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage”

Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke

“…Next, the crosstalk between astrocyte and microglia promotes the release of Wnt1-like proteins in astrocytes, which results in Wnt/β-catenin activation in microglial cells to hamper GSK-3β activation, resulting in a downregulation of proinflammatory mediators L'Episcopo et al, 2018). Most recently, our research has substantiated that ambroxol enhances neuronal survival and diminishes white matter fiber bundle damage through mitigating M1-like microglial activation and reducing pro-inflammatory cytokines accumulation in mice with ICH (Jiang et al, 2020).…”

“…Rotarod test was used to evaluate fore-and hind limb motor coordination and balance as described by our previous work (Yang et al, 2018;Jiang et al, 2020). The speed was initially set at 5 rpm and gradually increase to 35 rpm, and the latency to fall (or cling to and spin with the rod for 3 full rotations) within 3 min was recorded for further analysis.…”

“…Based on our previous investigation that 35 mg/kg and 70 mg/kg ambroxol could facilitate neuronal survival and decrease white matter fiber bundle injury by suppressing microglial activation and decreasing proinflammatory cytokine accumulation in mice with intracerebral hemorrhage (ICH), finally enhance functional recovery (Jiang et al, 2020). Here, to explore the effect of administration of ambroxol on functional recovery after ischemic stroke, three concentrations of ambrxol (35, 70, 100 mg/kg) were applied to assess the feasible therapeutic concentration.…”

“…Furthermore, previous researches have revealed that ambroxol therapy is safe and well-tolerated, and might provide a potential novel target for the treatment of Parkinson disease from bench to bedside (Migdalska-Richards et al, 2016;Silveira et al, 2019;Mullin et al, 2020). Most recently, our previous study represents that 35 mg/kg and 70 mg/kg ambroxol promotes neuronal survival and decreases white matter fiber bundle damage via mitigating microglial activation and reducing proinflammatory cytokine accumulation in mice with intracerebral hemorrhage (ICH) (Jiang et al, 2020). Above evidence suggests that ambroxol hold neuroprotective ability, except for fighting against post-stroke pneumonia.…”