Corrigendum to “Controlling alginate oxidation conditions for making alginate-gelatin hydrogels” [Carbohydr. Polym. 198 (2018) 509–517]

Emami, Zahra; Ehsani, Morteza; Zandi, Mojgan; Foudazi, Reza

doi:10.1016/j.carbpol.2018.12.038

Cited by 23 publications

(31 citation statements)

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“…Alginate is an alginic salt, a linear polysaccharide composing of β‐D‐mannuronic acid (M unit) and α‐L‐guluronic acid (G unit), jointed by 1, 4 linkages . This ionic polymer is made up of either M blocks, G blocks or mixed sequences named alternating blocks (MG blocks), and alginate can be categorized into guluronic or mannuronic homopolymer and the alternating structure consisting of MG blocks. The composition and distribution of blocks along the alginate molecular chain depend heavily on the type of algae and the alginate isolated from the harvesting time and part of algae .…”

Section: Introductionmentioning

confidence: 99%

Strontium ion substituted alginate‐based hydrogel fibers and its coordination binding model

Zhang

Wang

Weng

et al. 2019

J of Applied Polymer Sci

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Sr-alginate and Ca-alginate hydrogel fibers were fabricated via microfluidic spinning technology, and various analytical methods were adopted to characterize fibers and disclose the coordination model of Sr 2+ binding with alginate molecule chain. For both fibers, the more crosslinking sites of Sr 2+ with alginate molecule were illustrated in comparison with that of Ca 2+ . The more robust mechanical performance of Sr-alginate fibers than Ca-alginate counterpart was a strong indication of the more strong binding of Sr 2+ with alginate molecular chain. FTIR and electric conductivity disclosed the chelation type of Sr 2+ with alginate macromolecule being similar to that of Ca 2+ , which was core-shell of the analogous "egg-box" structure. Circular dichroism spectroscopy further certified the extra coordination sites for Sr 2+ with alginate molecule than Ca 2+ . Research on the coordination model will be more beneficial to optimizing the physicochemical properties of alginate fibers.

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Section: Introductionmentioning

confidence: 99%

Strontium ion substituted alginate‐based hydrogel fibers and its coordination binding model

Zhang

Wang

Weng

et al. 2019

J of Applied Polymer Sci

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“…ALG, typically obtained from brown seaweed, is a natural anionic polysaccharide with varying proportions of 1,4‐linked‐ d ‐mannuronate (M) and 1,4‐linked‐ l ‐guluronate (G) units. [ 27 ] It exhibits many favorable properties, including biocompatibility, ease of gelation by addition of divalent cations, low cost, etc., thus is extensively applied in drug delivery, tissue engineering and wound healing. However, ALG hydrogel is nonbiodegradable in mammals due to the absence of enzymes (i.e., alginase) that can breakdown the polymeric networks.…”

Section: Resultsmentioning

confidence: 99%

Engineering Microcapsules for Simultaneous Delivery of Combinational Therapeutics

Huang

Zhou

Chen

et al. 2020

Adv Materials Technologies

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The combination of chemo‐ and photothermal therapy is an effective strategy to improve clinical outcomes and minimize side effects. For simultaneously delivering chemo‐ and photothermal agents to the tumor region to exert their synergistic effect, an efficient and safe drug co‐delivery platform is in great need. Microcapsules (MCs) are promising drug carriers for local treatment of tumors. However, their applications in chemo‐photothermal combinational therapy have not been fully explored. Herein, novel doxorubicin (DOX) and indocyanine green (ICG)‐incorporated microcapsules (DIMCs) are reported for highly efficient delivery of combinational therapeutics. To obtain DIMCs with precise configuration and controlled drug release characteristics, the microfluidic double‐emulsion templating method is adopted and factors dominating the size and morphology of DIMCs are investigated. Under optimized conditions, DIMCs with well‐defined hydrogel cores and polymeric shells can be steadily prepared, which are hydrolytically degradable, allow for pH‐sensitive sustained release of the drug payload, and show excellent photothermal effects. The in vitro experiment shows that DIMCs exhibit significantly enhanced antitumor efficiency owing to the synergistic effects of chemo‐ and photothermal actives, showing great potential as a new therapeutic platform in local treatment of cancers.

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“…The first broad peak around 1620 cm −1 could be the overlap of CN vibration of Schiff's base at 1620 cm − 1 and amide I of uncrosslinked gelatin which was originally present at 1628 cm −1 . [ 14,34–36,38,41 ] The peak at 1558 cm −1 might be assigned to CN vibration of Schiff's base. [ 34 ] These two peaks are considered as the characteristic peaks of ADA‐GEL.…”

Section: Resultsmentioning

confidence: 99%

Biofabrication and Characterization of Alginate Dialdehyde‐Gelatin Microcapsules Incorporating Bioactive Glass for Cell Delivery Application

Reakasame

Jin

Zheng

et al. 2020

Macromolecular Bioscience

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cells are used. [2] This technique enables cell transplantation into the host body without using immunosuppressant drugs [1] and simultaneously avoiding cells to disperse from the targeted site. [5] Microand macroencapsulation approaches have been explored in cell-based therapy applications to treat many diseases, especially, diabetes. [4] Moreover, cell encapsulation has been used in the field of tissue regeneration. [6] In this case, the matrix acts as a scaffold which allows the encapsulated cells to proliferate and differentiate in the capsules. [2] Biomaterials that have been widely used for cell encapsulation are hydrogels [7,8] because they can provide a highly hydrated environment which is suitable for cell and tissue growth. [9] Alginatebased hydrogels have been widely used in tissue engineering (TE) because of their biocompatible character. [10] However, alginate hydrogels have some limitations including a slow degradability and poor cell adhesion capability. [11] Degradability of alginate can be improved, for example, by the oxidation of alginate leading to alginate dialdehyde (ADA). [10] Moreover, combination of specific proteins with alginate based hydrogels can improve the cell-matrix interaction of the hydrogel. [12] Gelatin (GEL) is the most popular protein which has been incorporated into ADA based hydrogels for TE applications forming ADA-GEL hydrogels. [10] Because gelatin contains a cellular binding motif, namely arginineglycine-aspartic acid sequence, ADA-GEL can improve the adhesion, differentiation, and proliferation of cells. [13] Gelatin can covalently crosslink with ADA through the Schiff base formation between the amino groups of lysine and hydroxylysine of gelatin and the aldehyde groups of ADA. [14,15] The extrusion method is the most common microencapsulation technique which needs only simple equipment for the fabrication process. With this approach, cell-laden microcapsules are produced by extruding the hydrogel precursor containing cells through a small needle to generate droplets of the mixture into an appropriate hardening bath which will harden the hydrogel precursor. Because ADA based hydrogels can be easily crosslinked using CaCl 2 solution, this approach has been used efficiently for the fabrication of ADA-GEL based microcapsules. However, the diameter of the microcapsules fabricated by this method is strongly related to the properties of the hydrogel precursor. [2] The The effect of the incorporation of 45S5 bioactive glass (BG) microparticles (mean particle size ≈ 2 µm) on the fabrication and physicochemical properties of alginate dialdehyde-gelatin hydrogel capsules is investigated. The addition of BG particles decreases the hydrogel gelation time by ≈79% and 91% for the samples containing 0.1% w/v and 0.5% w/v BG, respectively. Moreover, it results in increasing average diameter of hydrogel capsules produced via a pressure-driven extrusion technique from about 1000 µm for the samples without BG to about 1700 and 1900 µm for the samples containing BG at concentrations of 0...

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Corrigendum to “Controlling alginate oxidation conditions for making alginate-gelatin hydrogels” [Carbohydr. Polym. 198 (2018) 509–517]

Cited by 23 publications

References 0 publications

Strontium ion substituted alginate‐based hydrogel fibers and its coordination binding model

Strontium ion substituted alginate‐based hydrogel fibers and its coordination binding model

Engineering Microcapsules for Simultaneous Delivery of Combinational Therapeutics

Biofabrication and Characterization of Alginate Dialdehyde‐Gelatin Microcapsules Incorporating Bioactive Glass for Cell Delivery Application

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