Corrigendum to “Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives” [Acta Biomater. 7 (2011) 3150–3157]

Hot Glue Gun Releasing Biocompatible Tissue Adhesive

“…On the other hand, cells exposed to Dermabond showed only 40% viability, with no living cells on or around the glue itself (Figure C). Similar results have been documented for other PCLs and cyanoacrylates; the latter's cytotoxicity has been associated with the release of formaldehyde and other by‐products…”

“…The elastic modulus of the cyanoacrylate glue (≈140 kPa) was statistically significantly higher than that in all other tested groups, while that of fibrin gel lowest among the tested glues (≈40 kPa). These results showed that star‐PCL‐NHS glues provide a range of adhesive strengths that are significantly stronger than fibrin and other bioadhesive systems, and have up to 50% of the adhesive strength of cyanoacrylate . The data illustrate the high potential of the 13 kDa star‐PCL‐NHS for tissue adhesion: its melting temperature, ≈45 °C, is sufficiently above the body temperature, it solidifies when cooled to body temperature, and it possesses elasticity and adhesion properties.…”

“…Although very promising, currently available tissue adhesives have some inherent shortcomings that limit their use in the clinic. Cyanoacrylate‐based glues, for example, adhere very strongly to tissue but are associated with a severe inflammatory response and poor elasticity . On the other hand, hydrogels such as cross‐linked polyethylene glycol and fibrinogen‐based adhesives are considered safe but have relatively poor adhesion, i.e., glue‐tissue bonds and cohesion, integrity of the glue required to hold the tissue together .…”

“…An ideal bioadhesive should be liquid for ease of application but solidify quickly after administration . It should also maintain both adhesion and cohesion strength, biodegradability, elasticity, and biocompatibility . Here, we develop a medical glue gun concept in which a cylindrical bioadhesive polymer stick is inserted into a commercially available hot melt device.…”

“…We hypothesized that the integrity of this material, as well as its cohesive force, will be achieved via its solidification, while covalent bonds with surrounding tissue will produce the required adhesive strength . To avoid damage to nearby tissue and biologic molecules, the melting point of such a bioadhesive should be least possible above 37 °C (human body temperature) required for solidification in physiological conditions . To synthesize a biomaterial with precise melting point, without compromising biocompatibility and biodegradability, we developed a straightforward synthetic scheme ( Figure ) and produced a library of star‐PCL‐NHS polymers with varying melting points, governed by their length …”