Corrigendum to “Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance” [Vaccine 38(43) (2020) 6757–6765]

Bruce-Staskal, Pamela J.; Woods, R. Claude; Borisov, Oleg V.; Massare, Michael J.; Hahn, Timothy

doi:10.1016/j.vaccine.2021.01.064

Cited by 1 publication

(4 citation statements)

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“…Most research groups aim to quantify vaccine antigen levels [38][39][40]42,117], while others seek to estimate the viral particle concentration [41,118]. Other than that, vaccines can also be made of viral-like particles (VLPs).…”

Section: Spr Applications To Vaccine Production Monitoringmentioning

confidence: 99%

“…A SPR assay based on a biantennary glycan with terminal α-2,6 sialic acid residues that strongly bind human influenza virus strain HAs from 1999 to 2017 was introduced by Bruce-Staskal and colleagues [42]. An asialoglycan was immobilized on the reference surface.…”

Section: Spr For Quantification Of Vaccines Preparationsmentioning

confidence: 99%

“…The total binding levels recorded with their assay were impacted by stresses (temperature and pH) applied to the sample. As such, the proposed SPR assay can indirectly measure degradation and/or unfolding and, hence, be used to assess the half-life and stability of a vaccine preparation [42].…”

Section: Spr For Quantification Of Vaccines Preparationsmentioning

confidence: 99%

“…A concentration analysis is also possible [32][33][34][35], and as such, SPR represents an interesting alternative to enzyme-linked immunosorbent assays (ELISA) for quantitation purposes [36]. SPR technology has been used in multiple fields, such as drug screening [16][17][18]21]; drug potency assessments [37]; vaccine quantitation [38][39][40][41][42]; food safety (the detection of bacteria, pathogens, and other impurities) [43][44][45][46][47][48][49][50]; biotherapeutics characterization and quality control [51][52][53][54][55][56][57]; biotherapeutic safety [58]; medical diagnostics [20,[59][60][61][62][63]; environmental monitoring [64]; and bioproduction monitoring [55,[65][66][67][68]. Although little work has been done for the aim of using an SPR biosensor online or at-line from a bioreactor in an automatic fashion [67,…”

Section: Introductionmentioning

confidence: 99%

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On the Use of Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring

et al. 2021

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Biomanufacturers are being incited by regulatory agencies to transition from a quality by testing framework, where they extensively test their product after their production, to more of a quality by design or even quality by control framework. This requires powerful analytical tools and sensors enabling measurements of key process variables and/or product quality attributes during production, preferably in an online manner. As such, the demand for monitoring technologies is rapidly growing. In this context, we believe surface plasmon resonance (SPR)-based biosensors can play a role in enabling the development of improved bioprocess monitoring and control strategies. The SPR technique has been profusely used to probe the binding behavior of a solution species with a sensor surface-immobilized partner in an investigative context, but its ability to detect binding in real-time and without a label has been exploited for monitoring purposes and is promising for the near future. In this review, we examine applications of SPR that are or could be related to bioprocess monitoring in three spheres: biotherapeutics production monitoring, vaccine monitoring, and bacteria and contaminant detection. These applications mainly exploit SPR’s ability to measure solution species concentrations, but performing kinetic analyses is also possible and could prove useful for product quality assessments. We follow with a discussion on the limitations of SPR in a monitoring role and how recent advances in hardware and SPR response modeling could counter them. Mainly, throughput limitations can be addressed by multi-detection spot instruments, and nonspecific binding effects can be alleviated by new antifouling materials. A plethora of methods are available for cell growth and metabolism monitoring, but product monitoring is performed mainly a posteriori. SPR-based biosensors exhibit potential as product monitoring tools from early production to the end of downstream processing, paving the way for more efficient production control. However, more work needs to be done to facilitate or eliminate the need for sample preprocessing and to optimize the experimental protocols.

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