Corrigendum to “HMGB1 modulates Lewis cell autophagy and promotes cell survival via RAGE-HMGB1-Erk1/2 positive feedback during nutrient depletion” [Immunobiology 220 May (5) (2015) 539–44]

Su, Zhaoliang; Wang, T.; Zhu, Hua; Zhang, P.; Han, Rui; Liu, Y.; Ni, Ping; Shen, Huiling; Xu, Wenlin; Xu, Hui

doi:10.1016/j.imbio.2017.09.004

Cited by 2 publications

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“…Gao's team demonstrated that HMGB1 can participate in the activation of p-38 MAPK through TLR4 [ 11 ]. In addition, it has been reported that HMGB1 promotes the activity of the p-38 MAPK and the ERK1/2 pathway to enhance the inflammatory response in human bronchial epithelial cells by combining RAGE which was consistent with the experimental results of this study [ 35 ]. Based on these foundations, it is indicated that the effect of GA on the activation of the NF- κ B, the p-38 MAPK, and the ERK1/2 pathways in CLP rats may be related to HMGB1.…”

Section: Discussionsupporting

confidence: 92%

Glycyrrhizic Acid Protects Experimental Sepsis Rats against Acute Lung Injury and Inflammation

Shen

Hua

Chai

2022

Evidence-Based Complementary and Alternative Medicine

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Background. The incidence of acute lung injury/acute respiratory distress (ALI/ARDS) is high in sepsis aggravating morbidity and mortality. Glycyrrhizic acid (GA) has pharmacological activities in the treatment of inflammation and antiviral. Materials and Methods. Sepsis rats were constructed by the cecal ligation and puncture (CLP) surgery. After GA (25 and 50 mg/kg) injection, the survival rate, blood oxygen, biochemical indexes, myeloperoxidase (MPO) activity, and wet/dry weight ratio of the lung were observed. The bronchoalveolar lavage fluid was collected to count the cells and measure the level of TNF-α, IL-1β, IL-10, and high mobility group box-1 protein (HMGB1). Lung tissue sections were taken to observe the levels of histopathological injury and apoptosis by HE and TUNEL staining. The levels of HMGB1, TLR4, p-38 MAPK, NF-κB, and ERK1/2 proteins were observed by immunohistochemistry and Western blot. Results. GA treatment improved the survival rate, blood oxygen, ALT, AST, BUN, and Scr of CLP rats. It could advance the MPO activity, the wet/dry weight ratio, histopathological injury, apoptosis, and the IL-10 level in the lung. After GA injection, the number of total cells, neutrophils, and macrophages in the CLP rats was reduced and the levels of TNF-α, IL-1β, HMGB1, TLR4, p-38 MAPK, and ERK1/2 in the CLP rat were also repressed. Conclusions. GA treatment may improve the sepsis-induced ALI/ARDS and inflammation by inhibiting HMBG1. This study provided an experimental basis for the prevention and treatment of ALI/ARDS caused by sepsis.

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Section: Discussionsupporting

confidence: 92%

Glycyrrhizic Acid Protects Experimental Sepsis Rats against Acute Lung Injury and Inflammation

Shen

Hua

Chai

2022

Evidence-Based Complementary and Alternative Medicine

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“…Basal levels of autophagy are of great importance for maintaining cellular homeostasis under natural conditions [26][27][28]. Autophagy can be triggered by different causes of environmental stress such as nutritional deficiencies [29], hypoxia [30], amino acid deprivation [31,32], DNA or organelle damage [33,34], high temperatures [35], reactive oxygen species [36] or even hormonal alterations [37,38]. When the stimulus is exacerbated or if the damage is not reversed, autophagy ends up triggering cell death or activating apoptosis [39,40].…”

Section: Introductionmentioning

confidence: 99%

A dual death/survival role of autophagy in the adult ovary of Lagostomus maximus (Mammalia- Rodentia)

et al. 2020

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Follicular atresia is a cell death event that occurs in the great majority of follicles before ovulation in the mature mammalian ovary. Germ cell loss has been mainly associated to apoptosis although autophagy also seems to be at play. Aimed to increase our understanding on the possible cooperating role of autophagy and apoptosis in follicular atresia and/or follicular survival, we analyzed both programmed cell death mechanisms in a rodent model, the South American plains vizcacha, Lagostomus maximus. Female vizcacha shows highly suppressed apoptosis-dependent follicular atresia in the adult ovary, with continuous folliculogenesis and massive polyovulation. This strategy of massive ovulation requires a permanent remodeling of the ovarian architecture to maintain the availability of quiescent primordial follicles throughout the individual's reproductive lifespan. We report here our analysis of autophagy (BECN1, LAMP1 and LC3B-I/II) and apoptosis (BCL2 and ACTIVE CAS-PASE-3) markers which revealed interactive behaviors between both processes, with autophagy promoting survival or cell death depending on the ovarian structure. Strong BECN1, LC3B-II and LAMP1 staining was observed in atretic follicles and degenerating corpora lutea that also expressed nuclear ACTIVE CASPASE-3. Healthy follicles showed a slight expression of autophagy proteins but a strong expression of BCL2 and no detectable ACTIVE CASPASE-3. Transmission electron microscopy revealed a high formation of autophagosomes, autolysosomes and lysosomes in atretic follicles and degenerating corpora lutea and a low number of autophagic vesicles in normal follicles. The co-expression of LC3B-BECN1, LC3B-LAMP1 and LC3B-ACTIVE CASPASE-3 was only detected in atretic follicles and degenerating corpora lutea, while co-expression of BCL2-BECN1 was only observed in normal follicles. We propose that autophagy could act as a mechanism to eliminate altered follicles and remnant corpora lutea providing the necessary space for maturation of primordial follicles that continuously enter the growing follicular pool to sustain massive ovulation.

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Corrigendum to “HMGB1 modulates Lewis cell autophagy and promotes cell survival via RAGE-HMGB1-Erk1/2 positive feedback during nutrient depletion” [Immunobiology 220 May (5) (2015) 539–44]

Cited by 2 publications

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Glycyrrhizic Acid Protects Experimental Sepsis Rats against Acute Lung Injury and Inflammation

Glycyrrhizic Acid Protects Experimental Sepsis Rats against Acute Lung Injury and Inflammation

A dual death/survival role of autophagy in the adult ovary of Lagostomus maximus (Mammalia- Rodentia)

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