Corrigendum to “In vitro cytotoxicity evaluation of some substituted isatin derivatives” [Bioorg. Med. Chem. 15 (2007) 931–938]

Vine, Kara L.; Locke, Julie M.; Ranson, Marie; Benkendorff, Kirsten; Pyne, Stephen G.; Bremner, John B.

doi:10.1016/j.bmc.2007.03.032

Cited by 35 publications

(52 citation statements)

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“…During the research on the preparation of isatin derivatives, we observed that when commercially available isatin (3) was treated with large excess of NBS (5 equivalents) in MeCN at an ambient temperature with access to air, 5-bromoisatoic anhydride (6) was formed as a main product in 77 % yield. Surprisingly, 5,7-dibromoisatin (5) [32,33] was not produced during this reaction. The 1 H, 13 C NMR spectra of 6 confirmed the proposed structure and were in accordance with those reported in the literature [34][35][36].…”

Section: Resultsmentioning

confidence: 75%

Synthesis and biological evaluation of some amino- and sulfanyl-3H-quinazolin-4-one derivatives as potential anticancer agents

et al. 2015

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A series of 6-substituted quinazolinone derivatives were prepared by the reaction of 6-bromoquinazolinones with aryl or alkyl amines and thiols, in the presence of a Pd(OAc) 2 /Xantphos system, under Buchwald-Hartwig-type reaction conditions. The 6-bromoquinazolinones were obtained in the three-components reaction of 5-bromoisatoic anhydride, triethyl orthoformate and an appropriate amine. Biological screening of the potential cytotoxicity of synthesized compounds on HT29 and HCT116 cell lines, as well as on the lymphocytes, showed that some derivatives of quinazolinone have significant anticancer activities. The detailed synthesis, spectroscopic data, and biological assays were reported. Graphical abstract

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Section: Resultsmentioning

confidence: 75%

Synthesis and biological evaluation of some amino- and sulfanyl-3H-quinazolin-4-one derivatives as potential anticancer agents

et al. 2015

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“…Isatin derivatives 1a-d were prepared by known synthetic procedures. [31][32][33] Preparation of N-substituted 3,5-di-tert-butyl-4-hydroxybenzylindoline-2,3-diones 3a-c. A mixture of substituted isatin 1a-c (10 mmol), 3,5-di-tert-butyl-4-hydroxybenzylacetate 2 (1.73 g, 11 mmol) and triethylamine (a few drops) in absolute DMF (10 ml) was stirred under 70 o С for 5 h, and cooled to r.t. Resulted solution was treated with 10% aqueous NaCl (200 ml).…”

Section: Methodsmentioning

confidence: 99%

A catalyst-free and easy nucleophilic addition of certain isatins to sterically hindered 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone

Богданов¹,

Бухаров²,

Oludina³

et al. 2013

Arkivoc

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Addition of substituted isatins to 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone, generated in situ from 3,5-di-tert-butyl-4-hydroxybenzyl acetate, to form 1-substituted hydroxybenzylisatins, is reported. On the basis of these isatins novel isatin-3-thiosemicarbazones as well as isoindigo derivatives bearing a 2,6-di-tert-butylphenol moiety were obtained. The structures of all novel compounds are confirmed by IR, 1 H NMR and 13 C NMR.

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“…Preparation of hydrazones from indoline-2,3-diones is straightforward and well documented [13,[17][18][19][20][21][22], which makes this an attractive step for the final compound synthesis using high-throughput organic synthesis techniques.…”

Section: Selection Of the Scaffolds And Syn-thetic Strategymentioning

confidence: 99%

Solution Phase Synthesis of a 3,5,7-Substituted Indolin-2-one Library as Potential CDK2 Inhibitor Isosteres

Tymoshenko¹,

Gregg²,

Hirsch³

et al. 2008

LDDD

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A set of 4-[N'-(2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazino]-benzamides focused on specific interactions at the ATP binding cleft of CDK2 was synthesized. The synthetic strategy towards potential inhibitors included the preparation of p-nitrophenyl activated esters and use of polymer scavengers to facilitate amide bond formation and purification. Using this methodology, a focused library of 244 compounds was prepared.

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Corrigendum to “In vitro cytotoxicity evaluation of some substituted isatin derivatives” [Bioorg. Med. Chem. 15 (2007) 931–938]

Cited by 35 publications

References 0 publications

Synthesis and biological evaluation of some amino- and sulfanyl-3H-quinazolin-4-one derivatives as potential anticancer agents

Synthesis and biological evaluation of some amino- and sulfanyl-3H-quinazolin-4-one derivatives as potential anticancer agents

A catalyst-free and easy nucleophilic addition of certain isatins to sterically hindered 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone

Solution Phase Synthesis of a 3,5,7-Substituted Indolin-2-one Library as Potential CDK2 Inhibitor Isosteres

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