Corrigendum to “miR-183-5p Is a Potential Molecular Marker of Systemic Lupus Erythematosus”

Zhou, Shaolan; Zhang, Jing; Luan, Pengfei; Ma, Zhanbing; Deng, Jiehui; Zhu, Hong; Ma, Qian; Wang, Yanfeng; Huo, Zhenghao

doi:10.1155/2021/9818203

Cited by 2 publications

(2 citation statements)

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“…A foregoing study has illuminated that CTSB is linked with the PI3K/AKT pathway [30]. As reported, that PI3K/AKT signal transduction is a critical pathway for cell survival and proliferation, exerting a critical action in modulating the immune response and the release of in ammatory factor in vivo and in vitro via mediating the activation of downstream signaling molecules and participating in the occurrence and development of sepsis [31]. Consequently, the impact of sepsis on PI3K/AKT pathway was further explored.…”

Section: Discussionmentioning

confidence: 93%

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Curcumin Elevates microRNA‐183‐5p via Cathepsin B‐Mediated Phosphatidylinositol 3‐Kinase/AKT Pathway to Strengthen Lipopolysaccharide‐Stimulated Immune Function of Sepsis Mice

Liu

Feng

Hou

et al. 2022

Contrast Media & Molecular Imaging

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Curcumin (Cur), a natural polyphenol compound, has been testified to modulate innate immune responses and also showed anti-inflammatory properties. Nevertheless, the mechanism was still poorly unknown, especially regarding Cur-modulated microRNAs (miRNAs) under the inflammatory response. CD39+ regulatory T cells (Tregs) were provided with distinct immunosuppressive action and exerted a critical role in the modulation of immune balance in sepsis. Nevertheless, the impact of Cur on the immune function of sepsis mice has not been reported. In this study, the influence of Cur on the inflammatory response and immune function of sepsis mice via augment of miR-183-5p and Cathepsin B (CTSB)-mediated phosphatidylinositol 3-kinase (PI3K)/AKT pathway was explored. Adoption of 20 mg/kg Cur was for gavage. In the meantime, injection of plasmid vectors of interference with miR-183-5p or CTSB was into the tail vein. Intraperitoneal injection of lipopolysaccharide (10 mg/kg) was to stimulate model of sepsis mice. Histopathological changes of sepsis mice were observed. The contents of tumor necrosis factor-α and Interleukin (IL)-1β and IL-6 in serum of mice were examined. Detection of alanine aminotransferase, aspartate aminotransferase (AST), urea nitrogen (BUN), and creatinine in serum of mice was performed. Test of the percentage of CD39+ Tregs in tail venous blood of mice was implemented. Examination of miR-183-5p, CTSB, and PI3K/AKT was performed. The targeting of miR-183-5p and CTSB was detected. Cur was available to ameliorate the histological damage, to reduce the content of inflammatory factors, AST, and BUN, and to decline the percentage of CD39+ Tregs in tail venous blood of sepsis mice. Elevated miR-183-5p or silenced CTSB was available to further enhance the protection of Cur. Cur was available to accelerate miR-183-5p, which negatively modulated CTSB and Cur-mediated PI3K/AKT pathway via the miR-183-5p/CTSB axis to restrain inflammation of sepsis mice and enhance its immune function.

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Section: Discussionmentioning

confidence: 93%

“…ese results illuminated that Cur mediated the PI3K/AKT pathway via the miR-183-5p/CTSB axis in sepsis mice [29,30,31]. Data Availability e gures and tables used to support the ndings of this study are included in the article.…”

Section: Discussionmentioning

confidence: 99%