Corrigendum to 'Phosphorus, and nitrogen co-doped carbon dots as a fluorescent probe for real-time measurement of reactive oxygen and nitrogen species inside macrophages' [Biosens. Bioelectron. 79 (2016) 822–828]

Gong, Yunqian; Yu, Bin; Yang, Wen; Zhang, Xiaoling

doi:10.1016/j.bios.2016.03.058

Cited by 10 publications

(9 citation statements)

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“…Zhang et al prepared nitrogen-and phosphorusdoped C-dots by hydrothermal carbonization of adenosine-5′triphosphate. 159 The quantum yield of P,N-doped C-dots excited at 340 nm was as high as 23.5%. The P,N-doped C-dots have remarkable advantages of high sensitivity, rapid response time, wide response range, and high biocompatibility, making them suitable for in vivo reactive oxygen species (ROS)/reactive nitrogen species (RNS) detection and biological imaging.…”

Section: Boron/nitrogenmentioning

confidence: 98%

Improving the functionality of carbon nanodots: doping and surface functionalization

et al. 2016

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Distinct from conventional carbon nanostructures, such as fullerene, graphene, and carbon nanotubes, carbon nanodots (C-dots) exhibit unique properties such as strong fluorescence, high photostability, chemical inertness, low toxicity, and biocompatibility. Various synthetic routes for C-dots have been developed in the last few years, and now intense research efforts have been focused on improving their functionality. In this aspect, doping and surface functionalization are two major ways to control the chemical, optical, and electrical properties of C-dots. Doping introduces atomic impurities into C-dots to modulate their electronic structure, and surface functionalization modifies the C-dot surface with functional molecules or polymers. In this review, we summarize recent progress in doping and surface functionalization of C-dots for improving their functionality, and offer insight into controlling the properties of C-dots for a variety of applications ranging from biomedicine to optoelectronics to energy.

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Section: Boron/nitrogenmentioning

confidence: 98%

Improving the functionality of carbon nanodots: doping and surface functionalization

et al. 2016

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“…Besides, for intracellular pH sensing, interference from various metal ions, that remains present in the biological system, should be avoided. Earlier reports suggest that the emission of carbon dots are typically sensitive to trace amount of metal ions (like Fe 3+ , Cu 2+ ),, bio thiols (such as cysteine (Cys), glutathione (GSH) and reactive oxygen species (ROS), which could limit their potential application in bioimaging and bio sensing. Therefore, the emission characteristics of the Cdot/PVA composite were further investigated in presence of several essential metal ions such as Na + , K + , Ca 2+ , Mn 2+ , Cu 2+ , Mg 2+ , Zn 2+ , Fe 3+ , Co 2+ , Ni 2+ (5 μL of 1 M solution added).…”

Section: Resultsmentioning

confidence: 99%

Boron Doped Carbon Dots with Unusually High Photoluminescence Quantum Yield for Ratiometric Intracellular pH Sensing

et al. 2019

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Herein we report that boron doping in carbon dots results in increased photoluminescence (PL) quantum yield, which could be used for ratiometric intracellular pH sensing in cancer cell lines. Using a mixture of citric acid monohydrate, thiourea, and boric acid, microwave‐assisted synthesis of boron doped blue emitting carbon dots (B‐Cdots) with an average size of 3.5±1.0 nm was achieved. For B‐Cdots, the maximum quantum yield (QY) was observed to be 25.8 % (11.1 % (w/w) H3BO3 input concentration), whereas, the same was calculated to be 16.9 % and 11.4 % for Cdots (synthesized from citric acid monohydrate and thiourea only) and P‐Cdots (phosphorus doped carbon dots; synthesized using citric acid monohydrate, thiourea and phosphoric acid) (11.1 % (w/w) H3PO4 input concentration), respectively. The observed luminescence efficiencies as obtained from steady state and time‐resolved photoluminescence measurements suggest an alternative emission mechanism due to boron/phosphorus doping in carbon dots. We furthermore demonstrated facile composite formation using B‐Cdots and another carbon dots with orange emission in presence of polyvinyl alcohol (PVA), resulting in white light emission (0.31, 0.32; λex 380 nm). The white light emitting composite enabled ratiometric pH sensing in the aqueous medium and showed favorable uptake properties by cancerous cells for intracellular pH sensing as well.

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“…Prior research has demonstrated that excess ROS generated at the inflammation site lead to tissue damage . C‐dots possess numerous advantages, such as intrinsic peroxidase‐like activity, strong as well as stable fluorescence that offers resistance to photobleaching and blinking, and excellent biocompatibility, which make them widely applicable in biolabeling, bioimaging, biosensing, therapeutics, and other fields . Herein, C‐dots were used as a model cargo to inhibit local ROS generation as well as to enable real‐time monitoring of cargo diffusion in the hydrogel.…”

Section: Introductionmentioning

confidence: 99%

A Reloadable Self‐Healing Hydrogel Enabling Diffusive Transport of C‐Dots Across Gel–Gel Interface for Scavenging Reactive Oxygen Species

Chen

Zhang

et al. 2017

Adv Healthcare Materials

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While reloadable drug delivery platforms are highly prized for the treatment of a broad spectrum of diseases, the gel-gel interface between hydrogels hinders the intergel diffusive transport of drugs and thus limits the application of hydrogels as reloadable depots. Here, this study reports the circumvention of this barrier by employing a self-healing hydrogel prepared from N-carboxyethyl chitosan and sodium alginate dialdehyde, which are cross-linked via a reversible Schiff base linkage. The injectable and bioadhesive hydrogel shows a rapid gelation time of 47 s. The dynamic self-healing process enables the efficient diffusive transport of carbon quantum dots (C-dots) into an adjacent hydrogel, and thus, the C-dots can be used to scavenge reactive oxygen species from a remote inflammation site. Specifically, the diffusive transport of the C-dots in the self-healing hydrogel after three sequential reloading steps is sevenfold greater than that in the non-self-healing counterpart. In vivo, hematoxylin and eosin staining of the murine skin at the injection site shows no apparent symptoms of inflammation in the group treated with the reloadable self-healing hydrogel. The current strategy represents a promising and straightforward route for the design of a reloadable drug delivery system for future use in clinical application.

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Corrigendum to 'Phosphorus, and nitrogen co-doped carbon dots as a fluorescent probe for real-time measurement of reactive oxygen and nitrogen species inside macrophages' [Biosens. Bioelectron. 79 (2016) 822–828]

Cited by 10 publications

References 0 publications

Improving the functionality of carbon nanodots: doping and surface functionalization

Improving the functionality of carbon nanodots: doping and surface functionalization

Boron Doped Carbon Dots with Unusually High Photoluminescence Quantum Yield for Ratiometric Intracellular pH Sensing

A Reloadable Self‐Healing Hydrogel Enabling Diffusive Transport of C‐Dots Across Gel–Gel Interface for Scavenging Reactive Oxygen Species

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