Corrigendum to “Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases” [Food Chem. Toxicol. 146 111809]

Skalny, Anatoly V.; Lima, Thania Rios Rossi; Tao, Ke; Zhou, Ji; Bornhorst, Julia; Alekseenko, Svetlana I.; Aaseth, Jan; Anesti, Ourania; Sarigiannis, Dimosthenis; Tsatsakis, Aristidis; Aschner, Michael; Tinkov, Alexey A.

doi:10.1016/j.fct.2021.111999

Cited by 3 publications

(2 citation statements)

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“…In addition, there is also evidence that these same areas have a greater incidence of NCD and male infertility due to a complex interrelationship of chronic chemical and physical exposure factors, in conjunction with the contribution of lifestyle behavioral risk factors and the genetic background of individuals. In addition, exposure to heavy metals such as As, Cd, Hg, and Pb has also been shown to be linked to respiratory dysfunction and disease (Skalny et al 2021 ). Of course, this evidence is supportive in explaining the role of heavy metal exposure in compromised mucociliary clearance, diminished barrier function, respiratory tract inflammation, oxidative stress, and apoptosis.…”

Section: Human Semen As Environmental and Health Markermentioning

confidence: 99%

“…Of course, this evidence is supportive in explaining the role of heavy metal exposure in compromised mucociliary clearance, diminished barrier function, respiratory tract inflammation, oxidative stress, and apoptosis. Moreover, an association has also been provided between heavy metal exposure and the severity of viral diseases, including influenza and respiratory syncytial virus (Skalny et al 2021 ). The latter may be considered a result of the adverse effects of metal exposure on adaptive immunity.…”

Section: Human Semen As Environmental and Health Markermentioning

confidence: 99%

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Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas

Montano¹,

Donato

Bianco

et al. 2021

Environ Sci Pollut Res

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The epidemic of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted worldwide with its infectious spread and mortality rate. Thousands of articles have been published to tackle this crisis and many of these have indicated that high air pollution levels may be a contributing factor to high outbreak rates of COVID-19. Atmospheric pollutants, indeed, producing oxidative stress, inflammation, immuno-unbalance, and systemic coagulation, may be a possible significant co-factor of further damage, rendering the body prone to infections by a variety of pathogens, including viruses. Spermatozoa are extremely responsive to prooxidative effects produced by environmental pollutants and may serve as a powerful alert that signals the extent that environmental pressure, in a specific area, is doing damage to humans. In order to improve our current knowledge on this topic, this review article summarizes the relevant current observations emphasizing the weight that environmental pollution has on the sensitivity of a given population to several diseases and how semen quality, may be a potential indicator of sensitivity for virus insults (including SARS-CoV-2) in high polluted areas, and help to predict the risk for harmful effects of the SARS-CoV-2 epidemic. In addition, this review focused on the potential routes of virus transmission that may represent a population health risk and also identified the areas of critical importance that require urgent research to assess and manage the COVID-19 outbreak.

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Section: Human Semen As Environmental and Health Markermentioning

confidence: 99%

Section: Human Semen As Environmental and Health Markermentioning

confidence: 99%

Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas

Montano¹,

Donato

Bianco

et al. 2021

Environ Sci Pollut Res

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The Cd/Zn Axis: Emerging Concepts in Cellular Fate and Cytotoxicity

et al. 2023

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Cadmium (Cd) is a toxic and carcinogenic substance that is present in the natural environment. The underlying biomolecular mechanisms of Cd toxicity are not completely understood, and it continues to be a significant research target due to its impact on public health. The primary routes of exposure are through ingestion of contaminated food and water and inhalation. Cd’s long biological half-life of 10–30 years allows it to accumulate in the body, leading to organ dysfunction notably in the kidney, liver, bone, and lungs. Cd has similar biochemical characteristics to Zinc (Zn). It shares the import transporters, ZIP8 and ZIP14, to enter the cells. This competitive behavior can be observed in multiple instances throughout the progression of Cd toxicity. Future studies on the biochemical interactions of Cd and Zn will elucidate the potential protective effects of Zn supplementation in reducing the effects of Cd toxicity. In addition, research can be focused on discovering key proteins and effective pathways for Cd elimination that confer fewer adverse effects than current antioxidant therapies.

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Associations between High Blood Levels of Copper, Nickel and Chromium and Indicators of Their Adverse Effects on Respiratory Organs, Blood and the Immune System

Землянова¹,

Koldibekova²,

Goryaev³

et al. 2022

PH&LE

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Introduction: An urgent hygienic problem in the regions with intensive industrial development is the persistence of ambient air pollutants and their adverse health outcomes in the population leading to higher incidence rates of non-communicable diseases and their chronicity. Objective: To substantiate the relationships between high blood levels of copper, nickel, and chromium and biomarkers of their adverse effects on blood, respiratory and immune systems for the tasks of early detection and prevention of poor health outcomes of the combined inhalation exposure to copper, nickel and chromium oxides on the example of the adult population at risk. Materials and methods: We carried out a hygienic assessment of ambient air quality in residential areas and analyzed general population incidence and prevalence for 2016–2020. We also examined the health status of women of reproductive age environmentally exposed to nickel, chromium and copper oxides in the area of residence and of relatively unexposed controls. About 5,000 chemical, clinical, immunological, and biochemical tests were done in 2022. Results: We established associations between higher blood levels of copper, nickel, and chromium and changes in the indicators of adverse health effects. Biomarkers of nonspecific and specific sensitization, chronic inflammation accompanied by an imbalance in the humoral and cellular immunity were hyperproduction of eosinophils in the nasal mucus, blood lymphocytes, specific IgG to copper, a decrease in the phagocytic index and number; lower ferritin marked disorders of iron homeostasis, higher malondialdehyde indicated induction of oxidative processes, and a decrease in antioxidant activity gave evidence of depletion of the total antioxidant activity. Conclusions: It is expedient to use our findings for early detection and subsequent substantiation of targeted measures aimed at preventing disorders of the respiratory and immune systems, blood, and certain disorders involving the immune mechanism, etiopathogenetically related to the combined exposure to the metal oxides tested.

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Corrigendum to “Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases” [Food Chem. Toxicol. 146 111809]

Cited by 3 publications

References 0 publications

Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas

Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas

The Cd/Zn Axis: Emerging Concepts in Cellular Fate and Cytotoxicity

Associations between High Blood Levels of Copper, Nickel and Chromium and Indicators of Their Adverse Effects on Respiratory Organs, Blood and the Immune System

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