Corrosion Behavior and Biological Activity of Micro Arc Oxidation Coatings with Berberine on a Pure Magnesium Surface

Abstract

Bone tissue repair materials can cause problems such as inflammation around the implant, slow bone regeneration, and poor repair quality. In order to solve these problems, a coating was prepared by ultrasonic micro-arc oxidation and self-assembly technology on a pure magnesium substrate. We studied the effect of berberine on the performance of the ultrasonic micro-arc oxidation/polylactic acid and glycolic acid copolymer/berberine (UMAO/PLGA/BR) coating. The chemical and morphological character of the coating was analyzed using scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The corrosion properties were studied by potentiodynamic polarization and electrochemical impedance spectroscopy in a simulated body fluid. The cumulative release of drugs was tested by high-performance liquid chromatography. The results indicate that different amounts of BR can seal the corrosion channel to different extents. These coatings have a self-corrosion current density (Icorr) at least one order of magnitude lower than the UMAO coatings. When the BR content is 3.0 g/L, the self-corrosion current density of the UMAO/PLGA/BR coatings is the lowest (3.14 × 10−8 A/cm2) and the corrosion resistance is improved. UMAO/PLGA/BR coatings have excellent biological activity, which can effectively solve the clinical problem of rapid degradation of pure magnesium and easy infection.

Surface Modification of Mg0.8Ca Alloy via Wollastonite Micro-Arc Coatings: Significant Improvement in Corrosion Resistance

“…The released calcium ions, in turn, intensified apatite nucleation. Similar processes occurred during the dissolution of Ca-and Mg-silicates, such as akermanite [39] and forsterite [69].…”

“…Magnesium silicate, forsterite, and magnesium oxide were mainly formed in coating, since Mg, Si, and O prevailed in the elemental composition of the coating section. The authors of [69,70] wrote about the formation of forsterite and pericla interaction of the electrolyte containing sodium silicate with a magnesium substr thermore, as was revealed using the SEM EDX method, in addition to the oxide, M formed in the boundary protective layer between the coating and the substrate halo was observed in the XRD pattern of the coatings, one can conclude that the contained an amorphous phase. Moreover, with an increase in the voltage up t the amount of the amorphous phase in the coatings' phase composition increased ically.…”

“…Sainz et al [34] described the dissolution process of wollastonite in S reaction (6) took place in this case: Magnesium silicate, forsterite, and magnesium oxide were mainly formed inside the coating, since Mg, Si, and O prevailed in the elemental composition of the coating's cross-section. The authors of [69,70] wrote about the formation of forsterite and periclase in the interaction of the electrolyte containing sodium silicate with a magnesium substrate. Furthermore, as was revealed using the SEM EDX method, in addition to the oxide, MgF 2 also formed in the boundary protective layer between the coating and the substrate.…”

Effect of microarc oxidation on the properties of aluminum alloy samples

“…The oxide-containing coatings formed during MDO are characterized by high wear resistance [ [8], [9]], corrosion resistance [ [10], [11], [12], [13]], heat resistance [14]. Biologically active coatings obtained by this method are also well known [ [15], [16], [17]]. When applying this method, close attention is paid to the effect of microplasma discharges on the formed oxide coating.…”

Special Issue: Biointerface Coatings for Biomaterials and Biomedical Applications

“…When the BR content was 3.0 g/L, the self-corrosion current density of the UMAO/PLGA/BR coatings was the lowest (3.14 × 10 −8 A/cm 2 ), and the corrosion resistance was improved. UMAO/PLGA/BR coatings have excellent biological activity, which can effectively solve the clinical problem of rapid degradation of pure magnesium and easy infection [27]. In the report "Chemical and Biological Roles of Zinc in a Porous Titanium Dioxide Layer Formed by Micro-Arc Oxidation" by Shimabukuro et al, zinc incorporated by microarc oxidation (MAO) in porous titanium dioxide was investigated under physiological saline conditions.…”