Corrosion behavior, in vitro and in vivo biocompatibility of a newly developed Ti–16Nb–3Mo–1Sn superelastic alloy

Al-Zain, Yazan; Yamamoto, Akiko; Al-Ajlouni, Jihad; Al‐Abbadi, Mousa A.; Al-Sayyed, Manar Rizik; Aloweidi, Abdelkarim; Kim, Hee-Young; Miyazaki, Shuichi

doi:10.1016/j.msec.2019.109906

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…A Ti-16Nb-3 Mo-1Sn (at%) alloy was confirmed to have a same level of tissue reaction to that of the commercially pure titanium (cp-Ti) by rat subcutaneous implantation. [31] Ti-18Zr-11Nb-3Sn (at%) [32] and Ti-19Zr-10Nb-1Fe [33] alloys were found to have good cellular growth as same as that of the conventional Ni-Ti alloy. These reports suggest good biocompatibility of Ti-Zr-Nb-based alloys as the same level of conventional metallic biomaterials, but there is no in vitro and in vivo biocompatibility data on Ti-Zr-Nb-Sn-Mo alloys so far.…”

Section: Introductionmentioning

confidence: 85%

“…The results for the cp-Ti are adapted from the study by Al-Zain et al [31] In Vitro Cytocompatibility Tests: For the in vitro cytocompatibility tests, all specimens were squares having sides of 10 mm and a thickness of 1 mm. After the heat treatment process, the specimens were ground up to 1200 grit SiC paper, followed by polishing up to 3000 grit using alumina paste with 1 μm grain size.…”

Section: Methodsmentioning

confidence: 99%

“…Statistical analysis was carried out by Student t-test between RPE of the cp-Ti and that of the alloy. This procedure and the results for the cp-Ti are adapted from the study by Al-Zain et al [31] In Vivo Implantation Tests and Histological Evaluation: Both the control material (cp-Ti) and the 2.5Mo alloy specimens were implanted subcutaneously in 30 adult BALB/c rats with an average mass of 181.4 AE 36.7 g. The anesthetic protocol for all rats included intraperitoneal ketamine injection by a standard dose of 50 mg kg À1 body mass as demonstrated by previous investigators. [14,35,36] Each rat received the 2.5Mo alloy and cp-Ti specimens under subcutaneous tissue located immediately posterior to the right and left shoulder blades after appropriate shaving of the fur and sterilizing the area with 10% povidone iodine solution.…”

Section: Methodsmentioning

confidence: 99%

“…[37] The Medical Committee at the Deanship of Scientific Research of the University of Jordan approved all animal procedures and experiments. Detailed procedure for the histological evaluation is discussed in the study by Al-Zain et al [31]…”

Section: Methodsmentioning

confidence: 99%

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Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

et al. 2021

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Recently, metastable β‐type Ti alloys have attracted attention as promising materials for medical implants due to low Young's modulus and superior biocompatibility. The former is dependent on texture developed during the thermomechanical process. Herein, new Ti–Zr–Nb–Sn–Mo alloys with ultralow Young's modulus and excellent biocompatibility are developed as promising materials for medical implants. The effect of Mo on the microstructure and mechanical properties of the Ti–18Zr–5Nb–3Sn system is investigated. X‐ray diffraction (XRD) and scanning electron microscope (SEM) results reveal that Mo acts as a β‐phase stabilizer. Moreover, mechanical behavior and recrystallization texture show strong composition dependence; the 2.5Mo alloy shows the lowest Young's modulus of 40 GPa. This is due to the formation of a recrystallization texture with strong Goss component of <001>. Corrosion behavior of the 2.5Mo alloy in the cell culture medium is similar to that of the commercially pure titanium (cp‐Ti), suggesting excellent corrosion resistance in the biological environment. Both murine fibroblasts and osteoblastic cells show good growth on the 2.5Mo alloy as the same level of that on the cp‐Ti. Implantation into rat subcutaneous tissue confirms no significant difference in the tissue reaction between the 2.5Mo alloy and the cp‐Ti.

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Section: Introductionmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

et al. 2021

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“…Due to its attractive mechanical and biological properties it seems to be one of the most appropriate materials for orthopaedic purposes, and one of the safest. On the other hand, it may not pertain to recently introduced alloys that contain other metals, including niobium (Nb), tantalum (Ta) strontium (Sr), and yttrium (Y) [ 103 ], as well as antimicrobial properties of silver and copper in TiCu and TiAg coatings [ 104 , 105 , 106 ], and even newly introduced, mixed-metals, superelastic Ti16Nb3Mo1Sn and Ti19Zr10Nb1Fe alloys [ 107 , 108 ].…”

Section: The Limitations In Implant Manufacturing Technologies and Ap...mentioning

confidence: 99%

A Review on Biomaterials for Orthopaedic Surgery and Traumatology: From Past to Present

et al. 2022

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The principal features essential for the success of an orthopaedic implant are its shape, dimensional accuracy, and adequate mechanical properties. Unlike other manufactured products, chemical stability and toxicity are of increased importance due to the need for biocompatibility over an implants life which could span several years. Thus, the combination of mechanical and biological properties determines the clinical usefulness of biomaterials in orthopaedic and musculoskeletal trauma surgery. Materials commonly used for these applications include stainless steel, cobalt-chromium and titanium alloys, ceramics, polyethylene, and poly(methyl methacrylate) (PMMA) bone cement. This study reviews the properties of commonly used materials and the advantages and disadvantages of each, with special emphasis on the sensitivity, toxicity, irritancy, and possible mutagenic and teratogenic capabilities. In addition, the production and final finishing processes of implants are discussed. Finally, potential directions for future implant development are discussed, with an emphasis on developing advanced personalised implants, according to a patient’s stature and physical requirements.

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Tailoring deformation and superelastic behaviors of beta-type Ti-Nb-Mn-Sn alloys

Jawed

Liu

Wang

et al. 2020

Journal of the Mechanical Behavior of Biomedical Materials

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Corrosion behavior, in vitro and in vivo biocompatibility of a newly developed Ti–16Nb–3Mo–1Sn superelastic alloy

Cited by 6 publications

References 42 publications

Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

Synthesis and Characterization of a Ti–Zr‐Based Alloy with Ultralow Young's Modulus and Excellent Biocompatibility

A Review on Biomaterials for Orthopaedic Surgery and Traumatology: From Past to Present

Tailoring deformation and superelastic behaviors of beta-type Ti-Nb-Mn-Sn alloys

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