Corrosion fatigue behavior of additively manufactured biodegradable porous iron

Li, Yageng; Lietaert, Karel; Li, Wei; Zhang, X.Y.; Leeflang, M.A.; Zhou, Jie; Zadpoor, Amir A.

doi:10.1016/j.corsci.2019.05.003

Cited by 57 publications

(33 citation statements)

References 55 publications

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“…AM techniques such as binder-jetting three dimensional printing [151] and selective laser melting (SLM) [121,152,153] methods have been recently adopted to produce topologically-ordered porous Fe-based scaffolds with intricate architecture and uniform design. A controllable architecture having an optimized pore size and strut thickness and regular porosity throughout the structure as well as a larger electroactive exposed area can be attained via this AM technique.…”

Section: Current Development Of Porous Fe-based Scaffolds Fabrication Techniques To Produce Porous Fe-based Scaffoldsmentioning

confidence: 99%

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Yusop

Ulum

Sakkaf

et al. 2021

Biotechnology Journal

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Iron (Fe) and Fe-based materials have been vigorously explored in orthopedic applications in the past decade mainly owing to their promising mechanical properties including high yield strength, elastic modulus and ductility. Nevertheless, their corrosion products and low corrosion kinetics are the major concerns that need to be improved further despite their appealing mechanical strengths. The current studies on porous Fe-based scaffolds show an improved corrosion rate but the in vitro biocompatibility is still problematic in general. Unlike the Mg implants, the biodegradation and bioabsorption of Fe-based implants are still not well described. This vague issue could implicate the development of Fe-based materials as potential medical implants as they have not reached the clinical trial stage yet. Thus, there is a need to understand in-depth the Fe corrosion behavior and its bioabsorption mechanism to facilitate the material design of Fe-based scaffolds and further improve its biocompatibility. This manuscript provides an important insight into the basic bioabsorption of the multi-ranged Fe-based corrosion products with a review of the latest progress on the corrosion & in vitro biocompatibility of porous Fe-based scaffolds together with the remaining challenges and the perspective on the future direction.

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Section: Current Development Of Porous Fe-based Scaffolds Fabrication Techniques To Produce Porous Fe-based Scaffoldsmentioning

confidence: 99%

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Yusop

Ulum

Sakkaf

et al. 2021

Biotechnology Journal

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“…Precise process control is therefore needed in order to obtain eligible samples from AM for further investigation. Up to date, only a few studies on powder bed fusion AM porous biodegradable Mg, Fe, and Zn have appeared in the literature [37][38][39][40][41][42] . AM porous Mg and Fe have both demonstrated unique biodegradation behaviors, as compared to their bulk counterparts [37 , 38] .…”

Section: Introductionmentioning

confidence: 99%

Additively manufactured biodegradable porous zinc

et al. 2020

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Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising biomaterials with respect to biodegradation rate and biocompatibility. However, no information regarding the biodegradability and biocompatibility of topologically ordered AM porous zinc is yet available. Here, we applied powder bed fusion to fabricate porous zinc with a topologically ordered diamond structure. An integrative study was conducted on the static and dynamic biodegradation behavior ( in vitro , up to 4 weeks), evolution of mechanical properties with increasing immersion time, electrochemical performance, and biocompatibility of the AM porous zinc. The specimens lost 7.8% of their weight after 4 weeks of dynamic immersion in a revised simulated body fluid. The mechanisms of biodegradation were site-dependent and differed from the top of the specimens to the bottom. During the whole in vitro immersion time of 4 weeks, the elastic modulus values of the AM porous zinc ( E = 70 0-10 0 0 MPa) even increased and remained within the scope of those of cancellous bone. Indirect cytotoxicity revealed good cellular activity up to 72 h according to ISO 10,993-5 and -12. Live-dead staining confirmed good viability of MG-63 cells cultured on the surface of the AM porous zinc. These important findings could open up unprecedented opportunities for the development of multifunctional bone substituting materials that will enable reconstruction and regeneration of critical-size load-bearing bone defects. Statement of significanceNo information regarding the biodegradability and biocompatibility of topologically ordered AM porous zinc is available. We applied selective laser melting to fabricate topologically ordered porous zinc and conducted a comprehensive study on the biodegradation behavior, electrochemical performance, timedependent mechanical properties, and biocompatibility of the scaffolds. The specimens lost 7.8% of their weight after4 weeks dynamic biodegradation while their mechanical properties surprisingly increased after 4 weeks. Indirect cytotoxicity revealed good cellular activity up to 72 h. Intimate contact between MG-63 cells and the scaffolds was also observed. These important findings could open up unprecedented opportunities for the development of multifunctional bone substituting materials that mimic bone properties and enable full regeneration of critical-size load-bearing bony defects.

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“…Space holder techniques (SHT) have been identified as a low-cost route [26] to tailor porous titanium substrates with a high control of pore design (amount, morphology and pore size) which are key to obtain a balance response in relation to bone-implant integration and mechanical behavior. The large and irregular pores compromise the fatigue behavior of the implant as well as corrosion resistance, due to porosity [27,28]. However, at least a 100 µm average pore size [26,[29][30][31] is required to guide the cellular response and synthesis bone matrix.…”

Section: Introductionmentioning

confidence: 99%

Use of Impedance Spectroscopy for the Characterization of In-Vitro Osteoblast Cell Response in Porous Titanium Bone Implants

Giner

Olmo

Hernández

et al. 2020

Metals

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The use of titanium implants with adequate porosity (content, size and morphology) could solve the stress shielding limitations that occur in conventional titanium implants. Experiments to assess the cellular response (adhesion, proliferation and differentiation of osteoblasts) on implants are expensive, time-consuming and delicate. In this work, we propose the use of impedance spectroscopy to evaluate the growth of osteoblasts on porous titanium implants. Osteoblasts cells were cultured on fully-dense and 40 vol.% porous discs with two ranges of pore size (100–200 μm and 355–500 μm) to study cell viability, proliferation, differentiation (Alkaline phosphatase activity) and cell morphology. The porous substrates 40 vol.% (100–200 µm) showed improved osseointegration response as achieved more than 80% of cell viability and higher levels of Cell Differentiation by Alkaline Phosphatase (ALP) at 21 days. This cell behavior was further evaluated observing an increase in the impedance modulus for all study conditions when cells were attached. However, impedance levels were higher on fully-dense due to its surface properties (flat surface) than porous substrates (flat and pore walls). Surface parameters play an important role on the global measured impedance. Impedance is useful for characterizing cell cultures in different sample types.

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Corrosion fatigue behavior of additively manufactured biodegradable porous iron

Cited by 57 publications

References 55 publications

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Insight into the bioabsorption of Fe‐based materials and their current developments in bone applications

Additively manufactured biodegradable porous zinc

Use of Impedance Spectroscopy for the Characterization of In-Vitro Osteoblast Cell Response in Porous Titanium Bone Implants

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