Cortical activation resulting from the stimulation of periodontal mechanoreceptors measured by functional magnetic resonance imaging (fMRI)

Habre-Hallage, Pascale; Dricot, Laurence; Hermoye, Laurent; Reychler, Hervé; Steenberghe, Daniël van; Jacobs, Reinhilde; Grandin, Cécile

doi:10.1007/s00784-013-1174-1

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…Mechanical stimulation of the maxillary and mandibular right first molars, and left wrist was performed with a handmade tool based on the brush stimulator [ 17 ]. The stimulus tool consisted of a resin handle, silicone cap, and two optic fibers (E32-DC200F4R, Omron Corp., Kyoto, Japan) ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The superior spatial resolution of functional magnetic resonance (MR) imaging has revealed the somatotopic organization of the oral senses [ 14 , 15 , 16 ]. Mechanical stimulation of the maxillary right and left central incisors and canines by the von Frey filaments identified response locations in S1 and secondary somatosensory cortex (S2) [ 17 ]. The cortical projections in S1 were bilateral with slight contralateral predominance for 75% of canines.…”

Section: Introductionmentioning

confidence: 99%

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Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments

Shimada

Kanetaka

Hihara

et al. 2022

Heliyon

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments

Shimada

Kanetaka

Hihara

et al. 2022

Heliyon

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“…It can be assumed that the input from the periodontal and skin mechanoreceptors is regulated in the same manner. Teeth are represented in the somatosensory cortex as other skin body areas, 28 and the perception at teeth level is downregulated during jaw movement 9 as it is during limb movements 29 . Moreover, different exteroceptive inputs such as sound, vision and touch are modulated in the same manner further supporting the validity of the assumption.…”

Section: Discussionmentioning

confidence: 81%

Occlusal tactile acuity in temporomandibular disorder pain patients: A case‐control study

Bucci

Koutris

Palla

et al. 2020

J of Oral Rehabilitation

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Objective To compare the smallest thickness that can be perceived between occluding teeth (occlusal tactile acuity, OTA) of temporomandibular disorder pain (TMD‐P) patients with that of control (CTR) individuals. Methods Twenty TMD‐P patients (17 women and 3 men, mean age: 31.3 ± 10.4 years) diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol and 20 age‐ and gender‐matched controls (17 women and 3 men, mean age: 31.4 ± 10.5 years) were enrolled. The OTA was tested with 10 different thicknesses: 9 aluminium foils (8 µm‐72 µm with a constant increment of 8 µm) and 1 sham test (without foil), each thickness being tested 10 times in random order (100 tests in total). The participants were instructed to close their mouth once and to report whether they felt the foil between their molar teeth. A between‐group comparison (TMD‐P vs CTR) was performed for each testing thickness (analysis of variance for repeated measurements, with Bonferroni multiple correction) (P < .005). Results Significantly increased OTA was observed in the TMD‐P group for the thicknesses between 8 µm and 40 µm, while no significant differences were found for the sham test and for the larger thicknesses tested (from 48 µm to 72 µm). Conclusions TMD‐pain subjects presented an increased OTA as compared to controls.

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“…We observed an autoimmune response to neural receptors in El Bagre-EPF patients’ oral mucosa and salivary glands; indeed, we have described autoreactivity to skin neurovascular structures and neural receptors in previous studies [ 27 , 28 ]. The neuronal/transmitter control of salivary glands is performed by both dopaminergic and serotonergic neurons and receptors [ 29 ]. Both classes of transmitters elicit saliva secretion.…”

Section: Discussionmentioning

confidence: 99%

Subclinical oral involvement in patients with endemic pemphigus foliaceus

Velez

Howard

Padilla³

et al. 2018

Dermatol Pract Concept

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BackgroundWe have described a variant of endemic pemphigus foliaceus (EPF) in El Bagre area known as pemphigus Abreu-Manu. Our previous study suggested that Colombian EPF seemed to react with various plakin family proteins, such as desmoplakins, envoplakin, periplakin BP230, MYZAP, ARVCF, p0071 as well as desmoglein 1.ObjectivesTo explore whether patients affected by a new variant of endemic pemphigus foliaceus (El Bagre-EPF) demonstrated oral involvement.Materials and MethodsA case-control study was done by searching for oral changes in 45 patients affected by El Bagre-EPF, as well as 45 epidemiologically matched controls from the endemic area matched by demographics, oral hygiene habits, comorbidities, smoking habits, place of residence, age, sex, and work activity. Oral biopsies were taken and evaluated via hematoxylin and eosin staining, direct immunofluorescence, indirect immunofluorescence, confocal microscopy, and immunohistochemistry.ResultsRadicular pieces and loss of teeth were seen in in 43 of the 45 El Bagre-EPF patients and 20 of the 45 controls (P < 0.001) (confidence interval [CI] 98%). Hematoxylin and eosin staining showed 23 of 45 El Bagre-EPF patients had corneal/subcorneal blistering and lymphohistiocytic infiltrates under the basement membrane zone and around the salivary glands, the periodontal ligament, and the neurovascular bundles in all cell junction structures in the oral cavity; these findings were not seen in the controls (P < 0.001) (CI 98%). The direct immunofluorescence, indirect immunofluorescence, confocal microscopy, and microarray staining displayed autoantibodies to the salivary glands, including their serous acini and the excretory duct cell junctions, the periodontal ligament, the neurovascular bundles and their cell junctions, striated muscle and their cell junctions, neuroreceptors, and connective tissue cell junctions. The autoantibodies were polyclonal. IgA autoantibodies were found in neuroreceptors in the glands and were positive in 41 of 45 patients and 3 of 45 controls.ConclusionsPatients affected by El Bagre-EPF have some oral anomalies and an immune response, primarily to cell junctions. The intrinsic oral mucosal immune system, including IgA and secretory IgA, play an important role in this autoimmunity. Our data contradict the hypothesis that pemphigus foliaceus does not affect the oral mucosa due to the desmoglein 1-desmoglein 3 compensation.

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Cortical activation resulting from the stimulation of periodontal mechanoreceptors measured by functional magnetic resonance imaging (fMRI)

Abstract: The cortical somatotopy of periodontal mechanoreceptors is poorly described. These findings may serve as normal reference to further explore the cortical plasticity induced by periodontal or neurological diseases.

Cited by 16 publications

References 47 publications

Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments

Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments

Occlusal tactile acuity in temporomandibular disorder pain patients: A case‐control study

Subclinical oral involvement in patients with endemic pemphigus foliaceus

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