Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training

Henrique, Jéssica Salles; França, Erivelton Fernandes; Cardoso, Fabrízio Dos Santos; Serra, Fernando Tadeu; Almeida, Alexandre Aparecido de; Fernandes, Jansen; Arida, Ricardo Mário; Silva, Sérgio Gomes da

doi:10.1016/j.exger.2018.06.025

Cited by 20 publications

(12 citation statements)

References 43 publications

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“…In the aged brain, there is a reduction in the availability of neurotrophic factors such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), especially in the hippocampus; therefore, these changes may be linked with the large reduction in cell proliferation and increase in apoptosis in the dentate gyrus (8,198). Besides, TNF-α, a pro-inflammatory protein, could increase the process of apoptosis via intrinsic and extrinsic pathways, which is more significantly visible in aged brain and could be implicated in neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD) (Figure 4) (199)(200)(201).…”

Section: Apoptosis In Aged Brainmentioning

confidence: 99%

“…Exercise can upregulate BDNF in hippocampal and cortical neurons promoting synaptic remodeling and improving cell survival (202,203). Physical exercise inhibits the production of the pro-inflammatory cytokine TNF-α, which in low concentration decreases the process of apoptosis via the extrinsic pathway (200).…”

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

“…Aerobic exercise may induce events such as cell proliferation, survival and death through distinct mechanisms from those of resistance exercise (214,215). The RT consisted of bodybuilding exercises like adductor, abductor, leg presses, triceps and biceps exercises, or in a simpler way for rodents, it could be climbing a ladder repeatedly, for example (200,216,217). de Smolarek et al (217) showed that RT could be very suitable for the elderly population because they were able to see an improvement in cognition in elderly women (between 65 and 69 years old) submitted to resistance training for 12 weeks.…”

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

“…In another perspective, regarding animal studies, Henrique et al (200) compared two protocols, APE and RT. APE protocol used treadmill running, and RT protocol consisted of a series of eight climbs with a progressively heavier load, both for 7 weeks in 21-month-old rats.…”

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

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Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

et al. 2020

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The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism alive and healthy. Physical exercise, defined as planned, structured and repetitive physical activity, has been an important force to alter physiology and brain development during the process of human beings' evolution. Among several aspects of aging, the aim of this review is to discuss the balance between two vital cellular processes such as autophagy and apoptosis, based on the fact that physical exercise as a non-pharmacological strategy seems to rescue the imbalance between autophagy and apoptosis during aging. Therefore, the effects of different types or modalities of physical exercise in humans and animals, and the benefits of each of them on aging, will be discussed as a possible preventive strategy against neuronal death.

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Section: Apoptosis In Aged Brainmentioning

confidence: 99%

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

Section: Influence Of Physical Exercise In the Apoptosis Process In Amentioning

confidence: 99%

See 2 more Smart Citations

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

et al. 2020

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“…Interestingly, our proteomic array screen did not detect any significant change of JNK phosphorylation in the hippocampal lysates following voluntary wheel running in the current study. We speculate that this difference may be attributed to the varied paradigms applied, given that some prior studies have found that resistance training did not affect cortical or hippocampal JNK levels, whereas high-intensity treadmill running elevated the phosphorylation of JNK (Sun et al, 2017;Henrique et al, 2018).…”

Section: Discussionmentioning

confidence: 89%

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

Wang

Liang

Chen

et al. 2020

Front. Cell. Neurosci.

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Adiponectin, a cytokine secreted by mature adipocytes, proves to be neuroprotective. We have previously reported that running triggers adiponectin up-regulation which subsequently promotes generation of hippocampal neurons and thereby alleviates depression-like behaviors in non-stressed mice. However, under the stressing condition, whether adiponectin could still exert antidepressant-like effects following exercise remained unexplored. In this study, by means of repeated corticosterone injections to mimic stress insult and voluntary wheel running as physical exercise intervention, we examined whether exercise-elicited antidepressive effects might involve adiponectin's regulation on hippocampal neurogenesis and dendritic plasticity in stressed mice. Here we show that repeated injections of corticosterone inhibited hippocampal neurogenesis and impaired dendritic morphology of neurons in the dentate gyrus of both wild-type and adiponectin-knockout mice comparably, which subsequently evoked depression-like behaviors. Voluntary wheel running attenuated corticosterone-suppressed neurogenesis and enhanced dendritic plasticity in the hippocampus, ultimately reducing depressionlike behaviors in wild-type, but not adiponectin-knockout mice. We further demonstrate that such proneurogenic effects were potentially achieved through activation of the AMP-dependent kinase (AMPK) pathway. Our study provides the first evidence that adiponectin signaling is essential for physical exercise-triggered effects on stress-elicited depression by retaining the normal proliferation of neural progenitors and dendritic morphology of neurons in the hippocampal dentate gyrus, which may depend on activation of the AMPK pathway.

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Physical Activities and Prevention of Neurodegenerative Diseases

Joon¹,

Singla²,

Shen³

2022

Translational Informatics

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Cortical and hippocampal expression of inflammatory and intracellular signaling proteins in aged rats submitted to aerobic and resistance physical training

Cited by 20 publications

References 43 publications

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

Physical Activities and Prevention of Neurodegenerative Diseases

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